Q9NQW7: Xaa-Pro aminopeptidase 1

General Information

Protein names	- Xaa-Pro aminopeptidase 1 - 3.4.11.9 - Aminoacylproline aminopeptidase - Cytosolic aminopeptidase P - Soluble aminopeptidase P - sAmp - X-Pro aminopeptidase 1 - X-prolyl aminopeptidase 1, soluble
Gene names	XPNPEP1
Organism	Homo sapiens
Protease Family	M24.009
Protease ID	M24.009
Chromosome location
UniProt ID	Q9NQW7

4 N-termini

1 C-termini

0 Cleavages

8 Substrates

Sequence

Isoforms

- Isoform 2 of Xaa-Pro aminopeptidase 1 - Isoform 3 of Xaa-Pro aminopeptidase 1 - Isoform 4 of Xaa-Pro aminopeptidase 1

Sequence View

        10         20         30         40         50         60
MPPKVTSELL RQLRQAMRNS EYVTEPIQAY IIPSGDAHQS EYIAPCDCRR AFVSGFDGSA
        70         80         90        100        110        120
GTAIITEEHA AMWTDGRYFL QAAKQMDSNW TLMKMGLKDT PTQEDWLVSV LPEGSRVGVD
       130        140        150        160        170        180
PLIIPTDYWK KMAKVLRSAG HHLIPVKENL VDKIWTDRPE RPCKPLLTLG LDYTGISWKD
       190        200        210        220        230        240
KVADLRLKMA ERNVMWFVVT ALDEIAWLFN LRGSDVEHNP VFFSYAIIGL ETIMLFIDGD
       250        260        270        280        290        300
RIDAPSVKEH LLLDLGLEAE YRIQVHPYKS ILSELKALCA DLSPREKVWV SDKASYAVSE
       310        320        330        340        350        360
TIPKDHRCCM PYTPICIAKA VKNSAESEGM RRAHIKDAVA LCELFNWLEK EVPKGGVTEI
       370        380        390        400        410        420
SAADKAEEFR RQQADFVDLS FPTISSTGPN GAIIHYAPVP ETNRTLSLDE VYLIDSGAQY
       430        440        450        460        470        480
KDGTTDVTRT MHFGTPTAYE KECFTYVLKG HIAVSAAVFP TGTKGHLLDS FARSALWDSG
       490        500        510        520        530        540
LDYLHGTGHG VGSFLNVHEG PCGISYKTFS DEPLEAGMIV TDEPGYYEDG AFGIRIENVV
       550        560        570        580        590        600
LVVPVKTKYN FNNRGSLTFE PLTLVPIQTK MIDVDSLTDK ECDWLNNYHL TCRDVIGKEL
       610        620
QKQGRQEALE WLIRETQPIS KQH         10         20         30         40         50         60
MPPKVTSELL RQLRQAMRNS EYVTEPIQAY IIPSGDAHQS EYIAPCDCRR AFVSGFDGSA
        70         80         90        100        110        120
GTAIITEEHA AMWTDGRYFL QAAKQMDSNW TLMKMGLKDT PTQEDWLVSV LPEGSRVGVD
       130        140        150        160        170        180
PLIIPTDYWK KMAKVLRSAG HHLIPVKENL VDKIWTDRPE RPCKPLLTLG LDYTGISWKD
       190        200        210        220        230        240
KVADLRLKMA ERNVMWFVVT ALDEIAWLFN LRGSDVEHNP VFFSYAIIGL ETIMLFIDGD
       250        260        270        280        290        300
RIDAPSVKEH LLLDLGLEAE YRIQVHPYKS ILSELKALCA DLSPREKVWV SDKASYAVSE
       310        320        330        340        350        360
TIPKDHRCCM PYTPICIAKA VKNSAESEGM RRAHIKDAVA LCELFNWLEK EVPKGGVTEI
       370        380        390        400        410        420
SAADKAEEFR RQQADFVDLS FPTISSTGPN GAIIHYAPVP ETNRTLSLDE VYLIDSGAQY
       430        440        450        460        470        480
KDGTTDVTRT MHFGTPTAYE KECFTYVLKG HIAVSAAVFP TGTKGHLLDS FARSALWDSG
       490        500        510        520        530        540
LDYLHGTGHG VGSFLNVHEG PCGISYKTFS DEPLEAGMIV TDEPGYYEDG AFGIRIENVV
       550        560        570        580        590        600
LVVPVKTKYN FNNRGSLTFE PLTLVPIQTK MIDVDSLTDK ECDWLNNYHL TCRDVIGKEL
       610        620
QKQGRQEALE WLIRETQPIS KQH         10         20         30         40         50         60
MPPKVTSELL RQLRQAMRNS EYVTEPIQAY IIPSGDAHQS EYIAPCDCRR AFVSGFDGSA
        70         80         90        100        110        120
GTAIITEEHA AMWTDGRYFL QAAKQMDSNW TLMKMGLKDT PTQEDWLVSV LPEGSRVGVD
       130        140        150        160        170        180
PLIIPTDYWK KMAKVLRSAG HHLIPVKENL VDKIWTDRPE RPCKPLLTLG LDYTGISWKD
       190        200        210        220        230        240
KVADLRLKMA ERNVMWFVVT ALDEIAWLFN LRGSDVEHNP VFFSYAIIGL ETIMLFIDGD
       250        260        270        280        290        300
RIDAPSVKEH LLLDLGLEAE YRIQVHPYKS ILSELKALCA DLSPREKVWV SDKASYAVSE
       310        320        330        340        350        360
TIPKDHRCCM PYTPICIAKA VKNSAESEGM RRAHIKDAVA LCELFNWLEK EVPKGGVTEI
       370        380        390        400        410        420
SAADKAEEFR RQQADFVDLS FPTISSTGPN GAIIHYAPVP ETNRTLSLDE VYLIDSGAQY
       430        440        450        460        470        480
KDGTTDVTRT MHFGTPTAYE KECFTYVLKG HIAVSAAVFP TGTKGHLLDS FARSALWDSG
       490        500        510        520        530        540
LDYLHGTGHG VGSFLNVHEG PCGISYKTFS DEPLEAGMIV TDEPGYYEDG AFGIRIENVV
       550        560        570        580        590        600
LVVPVKTKYN FNNRGSLTFE PLTLVPIQTK MIDVDSLTDK ECDWLNNYHL TCRDVIGKEL
       610        620
QKQGRQEALE WLIRETQPIS KQH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 8 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NQW7-1-unknown	MPPKVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt94734
Q9NQW7-1-unknown	MPPKVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96651
Q9NQW7-2-unknown	PPKVTS...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NQW7-2-unknown	PPKVTS...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NQW7-2-unknown	PPKVTS...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NQW7-2-unknown	PPKVTS...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111641
Q9NQW7-2-unknown	PPKVTS...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111640
Q9NQW7-40-unknown	SEYIAP...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183239
Q9NQW7-40-unknown	SEYIAP...	40	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt183238
Q9NQW7-40-	SEYIAP...	40		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ISKQH	623	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ISKQH	623	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90352
...ISKQH	623	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt90353

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NPY_HUMAN	29	EAYP.\|.PSKP	inferred from experiment	unknown	MEROPS	von Horsten S	Frerker N et al.:Neuropeptide Y (NPY) cleaving e... (M24.009)	17223229,
TKN1_HUMAN	58	ARRP.\|.PKPQ	inferred from experiment	unknown	MEROPS	Mentlein R	Harbeck HT et al.:Aminopeptidase P from rat brain... (M24.009)	1645659,
TKN1-Isoform4_HUMAN	58	ARRP.\|.PKPQ	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC32157
TKN1-Isoform3_HUMAN	58	ARRP.\|.PKPQ	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC32157
TKN1-Isoform2_HUMAN	58	ARRP.\|.PKPQ	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC32157
KNG1-Isoform3_HUMAN	345	MKRP.\|.PPGF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC32153
KNG1_HUMAN	381	MKRP.\|.PPGF	inferred from experiment	unknown	MEROPS	Mentlein R	Harbeck HT et al.:Aminopeptidase P from rat brain... (M24.009)	1645659,
KNG1-Isoform2_HUMAN	381	MKRP.\|.PPGF	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC32153