TopFIND 4.0

P10997: Islet amyloid polypeptide

General Information

Protein names	- Islet amyloid polypeptide - Amylin - Diabetes-associated peptide - DAP - Insulinoma amyloid peptide
Gene names	IAPP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P10997

6

N-termini

6

C-termini

5

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MGILKLQVFL IVLSVALNHL KATPIESHQV EKRKCNTATC ATQRLANFLV HSSNNFGAIL
70 80
SSTNVGSNTY GKRNAVEVLK REPLNYLPL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P10997-23-unknown	TPIESH...	23		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P10997-34-unknown	KCNTAT...	34		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26637
P10997-71-unknown	GKRNAV...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8305
P10997-72-unknown	KRNAVE...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8306
P10997-73-unknown	RNAVEV...	73		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8307
P10997-74-unknown	NAVEVL...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26529

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...QVEKRK	33	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26637
	...GSNTYG	70	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8305
	...SNTYGK	71	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8306
	...NTYGKR	72	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8307
	...TYGKRN	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26529
	...AVEVLK	79	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000445980

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_HUMAN	33	EKRK.\|.KCNT	inferred from experiment	unknown	MEROPS	Steiner DF	Sanke T et al.:An islet amyloid peptide is der... (S08.073)	3053705,
CBPE_HUMAN	70	NTYG.\|.GKRN	inferred from experiment	unknown	MEROPS	Verchere CB	Wang J et al.:The prohormone convertase enzym... (M14.005)	11246872,
CBPE_HUMAN	71	TYGK.\|.KRNA	inferred from experiment	unknown	MEROPS	Verchere CB	Wang J et al.:The prohormone convertase enzym... (M14.005)	11246872,
CBPE_HUMAN	72	YGKR.\|.RNAV	inferred from experiment	unknown	MEROPS	Verchere CB	Wang J et al.:The prohormone convertase enzym... (M14.005)	11246872,
NEC1_HUMAN	73	GKRN.\|.NAVE	inferred from experiment	unknown	MEROPS	Verchere CB	Wang J et al.:The prohormone convertase enzym... (M14.005)	11246872,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)