TopFIND 4.0

P16870: Carboxypeptidase E

General Information

Protein names
- Carboxypeptidase E
- CPE
- 3.4.17.10
- Carboxypeptidase H
- CPH
- Enkephalin convertase
- Prohormone-processing carboxypeptidase
Gene names CPE
Organism Homo sapiens
Protease Family M14.005
Protease ID M14.005
Chromosome location
UniProt ID P16870

3

N-termini

2

C-termini

1

Cleavages

13

Substrates

Sequence

        10         20         30         40         50         60 
MAGRGGSALL ALCGALAACG WLLGAEAQEP GAPAAGMRRR RRLQQEDGIS FEYHRYPELR 
        70         80         90        100        110        120 
EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG 
       130        140        150        160        170        180 
RELLIFLAQY LCNEYQKGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS 
       190        200        210        220        230        240 
NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNMKKIVD QNTKLAPETK AVIHWIMDIP 
       250        260        270        280        290        300 
FVLSANLHGG DLVANYPYDE TRSGSAHEYS SSPDDAIFQS LARAYSSFNP AMSDPNRPPC 
       310        320        330        340        350        360 
RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKTYWED 
       370        380        390        400        410        420 
NKNSLISYLE QIHRGVKGFV RDLQGNPIAN ATISVEGIDH DVTSAKDGDY WRLLIPGNYK 
       430        440        450        460        470    
LTASAPGYLA ITKKVAVPYS PAAGVDFELE SFSERKEEEK EELMEWWKMM SETLNF

Isoforms

- Isoform 2 of Carboxypeptidase E

Sequence View

        10         20         30         40         50         60 
MAGRGGSALL ALCGALAACG WLLGAEAQEP GAPAAGMRRR RRLQQEDGIS FEYHRYPELR 
        70         80         90        100        110        120 
EALVSVWLQC TAISRIYTVG RSFEGRELLV IELSDNPGVH EPGEPEFKYI GNMHGNEAVG 
       130        140        150        160        170        180 
RELLIFLAQY LCNEYQKGNE TIVNLIHSTR IHIMPSLNPD GFEKAASQPG ELKDWFVGRS 
       190        200        210        220        230        240 
NAQGIDLNRN FPDLDRIVYV NEKEGGPNNH LLKNMKKIVD QNTKLAPETK AVIHWIMDIP 
       250        260        270        280        290        300 
FVLSANLHGG DLVANYPYDE TRSGSAHEYS SSPDDAIFQS LARAYSSFNP AMSDPNRPPC 
       310        320        330        340        350        360 
RKNDDDSSFV DGTTNGGAWY SVPGGMQDFN YLSSNCFEIT VELSCEKFPP EETLKTYWED 
       370        380        390        400        410        420 
NKNSLISYLE QIHRGVKGFV RDLQGNPIAN ATISVEGIDH DVTSAKDGDY WRLLIPGNYK 
       430        440        450        460        470    
LTASAPGYLA ITKKVAVPYS PAAGVDFELE SFSERKEEEK EELMEWWKMM SETLNF



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 13 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    P16870-26-unknown EAQEPG... 26 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P16870-37-unknown MRRRRR... 37 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt69470
    P16870-43-unknown LQQEDG... 43 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    P16870-43-unknown LQQEDG... 43 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt115509

C-termini

Cleavages

Substrates