P01350: Gastrin

General Information

Protein names	- Gastrin - Gastrin-71 - Gastrin component I - Gastrin-52 - G52 - Big gastrin - Gastrin component II - Gastrin-34 - G34 - Gastrin - Gastrin component III - Gastrin-17 - G17 - Gastrin-14 - G14 - Gastrin-6 - G6
Gene names	GAST
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01350

13 N-termini

13 C-termini

20 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MQRLCVYVLI FALALAAFSE ASWKPRSQQP DAPLGTGANR DLELPWLEQQ GPASHHRRQL
70 80 90 100
GPQGPPHLVA DPSKKQGPWL EEEEEAYGWM DFGRRSAEDE N

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 13 C-termini - 20 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01350-59-unknown	QLGPQG...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26972
P01350-59-unknown	QLGPQG...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27268
P01350-59-unknown	QLGPQG...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26518
P01350-59-unknown	QLGPQG...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26562
P01350-59-unknown	QLGPQG...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26827
P01350-59-unknown	QLGPQG...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9698
P01350-59-unknown	QLGPQG...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27119
P01350-76-unknown	QGPWLE...	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26519
P01350-76-unknown	QGPWLE...	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26563
P01350-80-unknown	LEEEEE...	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26708
P01350-81-unknown	EEEEEA...	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18360
P01350-82-unknown	EEEEAY...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18361
P01350-83-unknown	EEEAYG...	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18362
P01350-84-unknown	EEAYGW...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18363
P01350-87-unknown	YGWMDF...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26709
P01350-89-unknown	WMDFGR...	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26710
P01350-92-unknown	FGRRSA...	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26711
P01350-94-unknown	RRSAED...	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8301
P01350-95-unknown	RSAEDE...	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8302
P01350-96-unknown	SAEDEN...	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26520

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SHHRRQ	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26972
...SHHRRQ	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27268
...SHHRRQ	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26518
...SHHRRQ	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26562
...SHHRRQ	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26827
...SHHRRQ	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9698
...SHHRRQ	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27119
...DPSKKQ	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26519
...DPSKKQ	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26563
...KQGPWL	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26708
...QGPWLE	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18360
...GPWLEE	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18361
...PWLEEE	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18362
...WLEEEE	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18363
...EEEEAY	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26709
...EEAYGW	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26710
...YGWMDF	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26711
...WMDFGR	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8301
...MDFGRR	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8302
...DFGRRS	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26520

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC1_HUMAN	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Dickinson CJ	Sawada M et al.:Diminished prohormone convertas... (M14.005)	10771309,
NEC2_HUMAN	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	58	HRRQ.\|.QLGP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC1_HUMAN	75	SKKQ.\|.QGPW	inferred from experiment	unknown	MEROPS	Dickinson CJ	Sawada M et al.:Diminished prohormone convertas... (M14.005)	10771309,
NEC2_HUMAN	75	SKKQ.\|.QGPW	inferred from experiment	unknown	MEROPS	Yamada T	Dickinson CJ et al.:Specificity of prohormone conve... (S08.073)	7657815,
NEP_HUMAN	79	GPWL.\|.LEEE	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Pauwels S et al.:Degradation of human gastrin an... (M13.001)	2736261,
MEP1B_HUMAN	80	PWLE.\|.EEEE	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1B_HUMAN	81	WLEE.\|.EEEE	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1B_HUMAN	82	LEEE.\|.EEEA	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1B_HUMAN	83	EEEE.\|.EEAY	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
NEP_HUMAN	86	EEAY.\|.YGWM	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Pauwels S et al.:Degradation of human gastrin an... (M13.001)	2736261,
NEP_HUMAN	88	AYGW.\|.WMDF	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Pauwels S et al.:Degradation of human gastrin an... (M13.001)	2736261,
NEP_HUMAN	91	WMDF.\|.FGRR	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Pauwels S et al.:Degradation of human gastrin an... (M13.001)	2736261,
CBPE_HUMAN	93	DFGR.\|.RRSA	inferred from experiment	unknown	MEROPS	Dickinson CJ	Sawada M et al.:Diminished prohormone convertas... (M14.005)	10771309,
CBPE_HUMAN	94	FGRR.\|.RSAE	inferred from experiment	unknown	MEROPS	Dickinson CJ	Sawada M et al.:Diminished prohormone convertas... (M14.005)	10771309,
NEC1_HUMAN	95	GRRS.\|.SAED	inferred from experiment	unknown	MEROPS	Dickinson CJ	Sawada M et al.:Diminished prohormone convertas... (M14.005)	10771309,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)