P20396: Pro-thyrotropin-releasing hormone

General Information

Protein names	- Pro-thyrotropin-releasing hormone - Pro-TRH - Prothyroliberin - Thyrotropin-releasing hormone - TRH - Protirelin - TSH-releasing factor - Thyroliberin - Thyrotropin-releasing factor - TRF
Gene names	TRH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20396

7 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPGPWLLLAL ALTLNLTGVP GGRAQPEAAQ QEAVTAAEHP GLDDFLRQVE RLLFLRENIQ
        70         80         90        100        110        120
RLQGDQGEHS ASQIFQSDWL SKRQHPGKRE EEEEEGVEEE EEEEGGAVGP HKRQHPGRRE
       130        140        150        160        170        180
DEASWSVDVT QHKRQHPGRR SPWLAYAVPK RQHPGRRLAD PKAQRSWEEE EEEEEREEDL
       190        200        210        220        230        240
MPEKRQHPGK RALGGPCGPQ GAYGQAGLLL GLLDDLSRSQ GAEEKRQHPG RRAAWVREPL

EE

Isoforms

Sequence View

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Perturbation of System:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20396-25-unknown	QPEAAQ...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20396-84-unknown	QHPGKR...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26523
P20396-114-unknown	QHPGRR...	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26524
P20396-135-unknown	QHPGRR...	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26525
P20396-152-unknown	QHPGRR...	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26526
P20396-186-unknown	QHPGKR...	186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26527
P20396-227-unknown	QHPGRR...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26528

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WLSKRQ	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26523
...GPHKRQ	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26524
...TQHKRQ	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26525
...AVPKRQ	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26526
...MPEKRQ	185	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26527
...AEEKRQ	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26528
...EPLEE	242	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
NEC1_HUMAN	83	SKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS	Merops NEC1_HUMAN -> TRH_HUMAN @83
NEC1_HUMAN	113	HKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS	Merops NEC1_HUMAN -> TRH_HUMAN @113
NEC1_HUMAN	134	HKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS	Merops NEC1_HUMAN -> TRH_HUMAN @134
NEC1_HUMAN	151	PKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS	Merops NEC1_HUMAN -> TRH_HUMAN @151
NEC1_HUMAN	185	EKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS	Merops NEC1_HUMAN -> TRH_HUMAN @185
NEC1_HUMAN	226	EKRQ.\|.QHPG	inferred from experiment	unknown	MEROPS	Merops NEC1_HUMAN -> TRH_HUMAN @226

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)