P01275: Glucagon

General Information

Protein names	- Glucagon - Glicentin - Glicentin-related polypeptide - GRPP - Oxyntomodulin - OXM - OXY - Glucagon - Glucagon-like peptide 1 - GLP-1 - Incretin hormone - Glucagon-like peptide 1(7-37) - GLP-1(7-37) - Glucagon-like peptide 1(7-36) - GLP-1(7-36) - Glucagon-like peptide 2 - GLP-2
Gene names	GCG
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01275

22 N-termini

22 C-termini

23 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKSIYFVAGL FVMLVQGSWQ RSLQDTEEKS RSFSASQADP LSDPDQMNED KRHSQGTFTS
        70         80         90        100        110        120
DYSKYLDSRR AQDFVQWLMN TKRNRNNIAK RHDEFERHAE GTFTSDVSSY LEGQAAKEFI
       130        140        150        160        170        180
AWLVKGRGRR DFPEEVAIVE ELGRRHADGS FSDEMNTILD NLAARDFINW LIQTKITDRK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

22 N-termini - 22 C-termini - 23 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01275-53-unknown	HSQGTF...	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26555
P01275-56-unknown	GTFTSD...	56	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31896
P01275-59-unknown	TSDYSK...	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31897
P01275-62-unknown	YSKYLD...	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31898
P01275-65-unknown	YLDSRR...	65	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31899
P01275-68-unknown	SRRAQD...	68	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31900
P01275-71-unknown	AQDFVQ...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31901
P01275-73-unknown	DFVQWL...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17013
P01275-74-unknown	FVQWLM...	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31902
P01275-77-unknown	WLMNTK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31903
P01275-80-unknown	NTKRNR...	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31904
P01275-84-unknown	NRNNIA...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26511
P01275-84-unknown	NRNNIA...	84	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26556
P01275-92-unknown	HDEFER...	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26512
P01275-98-unknown	HAEGTF...	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26513
P01275-107-unknown	VSSYLE...	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26702
P01275-110-unknown	YLEGQA...	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26703
P01275-111-unknown	LEGQAA...	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26704
P01275-119-unknown	FIAWLV...	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26705
P01275-120-unknown	IAWLVK...	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26706
P01275-123-unknown	LVKGRG...	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26707
P01275-131-unknown	DFPEEV...	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26514
P01275-146-unknown	HADGSF...	146	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26515
P01275-146-unknown	HADGSF...	146	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01275-146-unknown	HADGSF...	146	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NEDKRH	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26555
...KRHSQG	55	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31896
...SQGTFT	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31897
...TFTSDY	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31898
...SDYSKY	64	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31899
...SKYLDS	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31900
...LDSRRA	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31901
...SRRAQD	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17013
...RRAQDF	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31902
...QDFVQW	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31903
...VQWLMN	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31904
...MNTKRN	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26511
...MNTKRN	83	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26556
...NIAKRH	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26512
...DEFERH	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26513
...TFTSDV	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26702
...SDVSSY	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26703
...DVSSYL	110	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26704
...QAAKEF	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26705
...AAKEFI	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26706
...EFIAWL	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26707
...GRGRRD	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26514
...ELGRRH	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26515

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_HUMAN	52	DKRH.\|.HSQG	inferred from experiment	unknown	MEROPS		Merops NEC2_HUMAN -> GLUC_HUMAN @52
TPP1_HUMAN	55	HSQG.\|.GTFT	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
TPP1_HUMAN	58	GTFT.\|.TSDY	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
TPP1_HUMAN	61	TSDY.\|.YSKY	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
TPP1_HUMAN	64	YSKY.\|.YLDS	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
TPP1_HUMAN	67	YLDS.\|.SRRA	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
TPP1_HUMAN	70	SRRA.\|.AQDF	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
MEP1A_HUMAN	72	RAQD.\|.DFVQ	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
TPP1_HUMAN	73	AQDF.\|.FVQW	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
TPP1_HUMAN	76	FVQW.\|.WLMN	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
TPP1_HUMAN	79	WLMN.\|.NTKR	inferred from experiment	unknown	MEROPS	Warburton MJ	Vines D et al.:Purification and characterisati... (S53.003)	9659384,
NEC1_HUMAN	83	TKRN.\|.NRNN	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @83
NEC2_HUMAN	83	TKRN.\|.NRNN	inferred from experiment	unknown	MEROPS		Merops NEC2_HUMAN -> GLUC_HUMAN @83
NEC1_HUMAN	91	AKRH.\|.HDEF	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @91
NEC1_HUMAN	97	FERH.\|.HAEG	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @97
NEP_HUMAN	106	TSDV.\|.VSSY	inferred from experiment	unknown	MEROPS	Voigt K	Hupe-Sodmann K et al.:Characterisation of the process... (M13.001)	8577927,
NEP_HUMAN	109	VSSY.\|.YLEG	inferred from experiment	unknown	MEROPS	Voigt K	Hupe-Sodmann K et al.:Characterisation of the process... (M13.001)	8577927,
NEP_HUMAN	110	SSYL.\|.LEGQ	inferred from experiment	unknown	MEROPS	Voigt K	Hupe-Sodmann K et al.:Characterisation of the process... (M13.001)	8577927,
NEP_HUMAN	118	AKEF.\|.FIAW	inferred from experiment	unknown	MEROPS	Voigt K	Hupe-Sodmann K et al.:Characterisation of the process... (M13.001)	8577927,
NEP_HUMAN	119	KEFI.\|.IAWL	inferred from experiment	unknown	MEROPS	Voigt K	Hupe-Sodmann K et al.:Characterisation of the process... (M13.001)	8577927,
NEP_HUMAN	122	IAWL.\|.LVKG	inferred from experiment	unknown	MEROPS	Voigt K	Hupe-Sodmann K et al.:Characterisation of the process... (M13.001)	8577927,
NEC1_HUMAN	130	GRRD.\|.DFPE	inferred from experiment	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @130
NEC1_HUMAN	145	GRRH.\|.HADG	inferred from in-silico analysis	unknown	MEROPS		Merops NEC1_HUMAN -> GLUC_HUMAN @145

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)