P04085: Platelet-derived growth factor subunit A

General Information

Protein names	- Platelet-derived growth factor subunit A - PDGF subunit A - PDGF-1 - Platelet-derived growth factor A chain - Platelet-derived growth factor alpha polypeptide
Gene names	PDGFA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04085

2 N-termini

2 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRTLACLLLL GCGYLAHVLA EEAEIPREVI ERLARSQIHS IRDLQRLLEI DSVGSEDSLD
        70         80         90        100        110        120
TSLRAHGVHA TKHVPEKRPL PIRRKRSIEE AVPAVCKTRT VIYEIPRSQV DPTSANFLIW
       130        140        150        160        170        180
PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA
       190        200        210
TTSLNPDYRE EDTGRPRESG KKRKRKRLKP T

Isoforms

- Isoform Short of Platelet-derived growth factor subunit A

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P04085-1-unknown	MRTLAC...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84732
P04085-87-unknown	SIEEAV...	87	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P04085-87-unknown	SIEEAV...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26978
P04085-87-unknown	SIEEAV...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27274
P04085-87-unknown	SIEEAV...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16283
P04085-87-unknown	SIEEAV...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26567
P04085-87-unknown	SIEEAV...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26833
P04085-87-unknown	SIEEAV...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9705
P04085-87-unknown	SIEEAV...	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27125
P04085-87-unknown	SIEEAV...	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115838

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...IRRKRS	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26978
...IRRKRS	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27274
...IRRKRS	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16283
...IRRKRS	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26567
...IRRKRS	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26833
...IRRKRS	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9705
...IRRKRS	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27125
...IRRKRS	86	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124847
...RLKPT	211	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	86	RKRS.\|.SIEE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	86	RKRS.\|.SIEE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
KLK4_HUMAN	86	RKRS.\|.SIEE	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
NEC2_HUMAN	86	RKRS.\|.SIEE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	86	RKRS.\|.SIEE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	86	RKRS.\|.SIEE	inferred from experiment	unknown	MEROPS	Seidah NG	Siegfried G et al.:The proteolytic processing of p... (S08.071)	12670890,
PCSK6_HUMAN	86	RKRS.\|.SIEE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)