Q92673: Sortilin-related receptor
Protein names | - Sortilin-related receptor - Low-density lipoprotein receptor relative with 11 ligand-binding repeats - LDLR relative with 11 ligand-binding repeats - LR11 - SorLA-1 - Sorting protein-related receptor containing LDLR class A repeats - SorLA |
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Gene names | SORL1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q92673 |
6
N-termini
2
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MATRSSRRES RLPFLFTLVA LLPPGALCEV WTQRLHGGSA PLPQDRGFLV VQGDPRELRL
70 80 90 100 110 120
WARGDARGAS RADEKPLRRK RSAALQPEPI KVYGQVSLND SHNQMVVHWA GEKSNVIVAL
130 140 150 160 170 180
ARDSLALARP KSSDVYVSYD YGKSFKKISD KLNFGLGNRS EAVIAQFYHS PADNKRYIFA
190 200 210 220 230 240
DAYAQYLWIT FDFCNTLQGF SIPFRAADLL LHSKASNLLL GFDRSHPNKQ LWKSDDFGQT
250 260 270 280 290 300
WIMIQEHVKS FSWGIDPYDK PNTIYIERHE PSGYSTVFRS TDFFQSRENQ EVILEEVRDF
310 320 330 340 350 360
QLRDKYMFAT KVVHLLGSEQ QSSVQLWVSF GRKPMRAAQF VTRHPINEYY IADASEDQVF
370 380 390 400 410 420
VCVSHSNNRT NLYISEAEGL KFSLSLENVL YYSPGGAGSD TLVRYFANEP FADFHRVEGL
430 440 450 460 470 480
QGVYIATLIN GSMNEENMRS VITFDKGGTW EFLQAPAFTG YGEKINCELS QGCSLHLAQR
490 500 510 520 530 540
LSQLLNLQLR RMPILSKESA PGLIIATGSV GKNLASKTNV YISSSAGARW REALPGPHYY
550 560 570 580 590 600
TWGDHGGIIT AIAQGMETNE LKYSTNEGET WKTFIFSEKP VFVYGLLTEP GEKSTVFTIF
610 620 630 640 650 660
GSNKENVHSW LILQVNATDA LGVPCTENDY KLWSPSDERG NECLLGHKTV FKRRTPHATC
670 680 690 700 710 720
FNGEDFDRPV VVSNCSCTRE DYECDFGFKM SEDLSLEVCV PDPEFSGKSY SPPVPCPVGS
730 740 750 760 770 780
TYRRTRGYRK ISGDTCSGGD VEARLEGELV PCPLAEENEF ILYAVRKSIY RYDLASGATE
790 800 810 820 830 840
QLPLTGLRAA VALDFDYEHN CLYWSDLALD VIQRLCLNGS TGQEVIINSG LETVEALAFE
850 860 870 880 890 900
PLSQLLYWVD AGFKKIEVAN PDGDFRLTIV NSSVLDRPRA LVLVPQEGVM FWTDWGDLKP
910 920 930 940 950 960
GIYRSNMDGS AAYHLVSEDV KWPNGISVDD QWIYWTDAYL ECIERITFSG QQRSVILDNL
970 980 990 1000 1010 1020
PHPYAIAVFK NEIYWDDWSQ LSIFRASKYS GSQMEILANQ LTGLMDMKIF YKGKNTGSNA
1030 1040 1050 1060 1070 1080
CVPRPCSLLC LPKANNSRSC RCPEDVSSSV LPSGDLMCDC PQGYQLKNNT CVKQENTCLR
1090 1100 1110 1120 1130 1140
NQYRCSNGNC INSIWWCDFD NDCGDMSDER NCPTTICDLD TQFRCQESGT CIPLSYKCDL
1150 1160 1170 1180 1190 1200
EDDCGDNSDE SHCEMHQCRS DEYNCSSGMC IRSSWVCDGD NDCRDWSDEA NCTAIYHTCE
1210 1220 1230 1240 1250 1260
ASNFQCRNGH CIPQRWACDG DTDCQDGSDE DPVNCEKKCN GFRCPNGTCI PSSKHCDGLR
1270 1280 1290 1300 1310 1320
DCSDGSDEQH CEPLCTHFMD FVCKNRQQCL FHSMVCDGII QCRDGSDEDA AFAGCSQDPE
1330 1340 1350 1360 1370 1380
FHKVCDEFGF QCQNGVCISL IWKCDGMDDC GDYSDEANCE NPTEAPNCSR YFQFRCENGH
1390 1400 1410 1420 1430 1440
CIPNRWKCDR ENDCGDWSDE KDCGDSHILP FSTPGPSTCL PNYYRCSSGT CVMDTWVCDG
1450 1460 1470 1480 1490 1500
YRDCADGSDE EACPLLANVT AASTPTQLGR CDRFEFECHQ PKTCIPNWKR CDGHQDCQDG
1510 1520 1530 1540 1550 1560
RDEANCPTHS TLTCMSREFQ CEDGEACIVL SERCDGFLDC SDESDEKACS DELTVYKVQN
1570 1580 1590 1600 1610 1620
LQWTADFSGD VTLTWMRPKK MPSASCVYNV YYRVVGESIW KTLETHSNKT NTVLKVLKPD
1630 1640 1650 1660 1670 1680
TTYQVKVQVQ CLSKAHNTND FVTLRTPEGL PDAPRNLQLS LPREAEGVIV GHWAPPIHTH
1690 1700 1710 1720 1730 1740
GLIREYIVEY SRSGSKMWAS QRAASNFTEI KNLLVNTLYT VRVAAVTSRG IGNWSDSKSI
1750 1760 1770 1780 1790 1800
TTIKGKVIPP PDIHIDSYGE NYLSFTLTME SDIKVNGYVV NLFWAFDTHK QERRTLNFRG
1810 1820 1830 1840 1850 1860
SILSHKVGNL TAHTSYEISA WAKTDLGDSP LAFEHVMTRG VRPPAPSLKA KAINQTAVEC
1870 1880 1890 1900 1910 1920
TWTGPRNVVY GIFYATSFLD LYRNPKSLTT SLHNKTVIVS KDEQYLFLVR VVVPYQGPSS
1930 1940 1950 1960 1970 1980
DYVVVKMIPD SRLPPRHLHV VHTGKTSVVI KWESPYDSPD QDLLYAVAVK DLIRKTDRSY
1990 2000 2010 2020 2030 2040
KVKSRNSTVE YTLNKLEPGG KYHIIVQLGN MSKDSSIKIT TVSLSAPDAL KIITENDHVL
2050 2060 2070 2080 2090 2100
LFWKSLALKE KHFNESRGYE IHMFDSAMNI TAYLGNTTDN FFKISNLKMG HNYTFTVQAR
2110 2120 2130 2140 2150 2160
CLFGNQICGE PAILLYDELG SGADASATQA ARSTDVAAVV VPILFLILLS LGVGFAILYT
2170 2180 2190 2200 2210
KHRRLQSSFT AFANSHYSSR LGSAIFSSGD DLGEDDEDAP MITGFSDDVP MVIA
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
6 N-termini - 2 C-termini - 6 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q92673-29-unknown | EVWTQR... | 29 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q92673-82-unknown | SAALQP... | 82 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q92673-82-unknown | SAALQP... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26650 | |||
Q92673-82-unknown | SAALQP... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26920 | |||
Q92673-82-unknown | SAALQP... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27218 | |||
Q92673-82-unknown | SAALQP... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9818 | |||
Q92673-82-unknown | SAALQP... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27070 | |||
Q92673-82-unknown | SAALQP... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27365 | |||
Q92673-1057-unknown | MCDCPQ... | 1057 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000434634 | |||
Q92673-1155-unknown | MHQCRS... | 1155 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000432131 | |||
Q92673-1406- | SHILPF... | 1406 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q92673-1424- | YRCSSG... | 1424 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LRRKRS | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26650 | |||
...LRRKRS | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26920 | |||
...LRRKRS | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27218 | |||
...LRRKRS | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9818 | |||
...LRRKRS | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27070 | |||
...LRRKRS | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27365 | |||
...PMVIA | 2214 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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