P08581: Hepatocyte growth factor receptor

General Information

Protein names	- Hepatocyte growth factor receptor - HGF receptor - 2.7.10.1 - HGF/SF receptor - Proto-oncogene c-Met - Scatter factor receptor - SF receptor - Tyrosine-protein kinase Met
Gene names	MET
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P08581

3 N-termini

2 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Hepatocyte growth factor receptor - Isoform 3 of Hepatocyte growth factor receptor

Sequence View

        10         20         30         40         50         60
MKAPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET PIQNVILHEH
        70         80         90        100        110        120
HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL
       130        140        150        160        170        180
VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL
       190        200        210        220        230        240
GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE
       250        260        270        280        290        300
FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL
       310        320        330        340        350        360
TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS
       370        380        390        400        410        420
AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF
       430        440        450        460        470        480
TTALQRVDLF MGQFSEVLLT SISTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL
       490        500        510        520        530        540
LDSHPVSPEV IVEHTLNQNG YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW
       550        560        570        580        590        600
CHDKCVRSEE CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK
       610        620        630        640        650        660
TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPVIT
       670        680        690        700        710        720
SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF
       730        740        750        760        770        780
AVKLKIDLAN RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH
       790        800        810        820        830        840
EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV
       850        860        870        880        890        900
FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL
       910        920        930        940        950        960
LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISTALLLLLG FFLWLKKRKQ
       970        980        990       1000       1010       1020
IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS
      1030       1040       1050       1060       1070       1080
CRQVQYPLTD MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF
      1090       1100       1110       1120       1130       1140
NEVIGRGHFG CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL
      1150       1160       1170       1180       1190       1200
SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF
      1210       1220       1230       1240       1250       1260
VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF
      1270       1280       1290       1300       1310       1320
TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW
      1330       1340       1350       1360       1370       1380
HPKAEMRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADDEVD
      1390
TRPASFWETS         10         20         30         40         50         60
MKAPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET PIQNVILHEH
        70         80         90        100        110        120
HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL
       130        140        150        160        170        180
VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL
       190        200        210        220        230        240
GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE
       250        260        270        280        290        300
FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL
       310        320        330        340        350        360
TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS
       370        380        390        400        410        420
AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF
       430        440        450        460        470        480
TTALQRVDLF MGQFSEVLLT SISTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL
       490        500        510        520        530        540
LDSHPVSPEV IVEHTLNQNG YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW
       550        560        570        580        590        600
CHDKCVRSEE CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK
       610        620        630        640        650        660
TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPVIT
       670        680        690        700        710        720
SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF
       730        740        750        760        770        780
AVKLKIDLAN RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH
       790        800        810        820        830        840
EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV
       850        860        870        880        890        900
FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL
       910        920        930        940        950        960
LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISTALLLLLG FFLWLKKRKQ
       970        980        990       1000       1010       1020
IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS
      1030       1040       1050       1060       1070       1080
CRQVQYPLTD MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF
      1090       1100       1110       1120       1130       1140
NEVIGRGHFG CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL
      1150       1160       1170       1180       1190       1200
SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF
      1210       1220       1230       1240       1250       1260
VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF
      1270       1280       1290       1300       1310       1320
TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW
      1330       1340       1350       1360       1370       1380
HPKAEMRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADDEVD
      1390
TRPASFWETS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P08581-1-unknown	MKAPAV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80948
P08581-1-unknown	MKAPAV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80949
P08581-25-unknown	ECKEAL...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08581-25-unknown	ECKEAL...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113828
P08581-25-unknown	ECKEAL...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113829
P08581-308-unknown	STKKEV...	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27144
P08581-308-unknown	STKKEV...	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26997
P08581-308-unknown	STKKEV...	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27296
P08581-308-unknown	STKKEV...	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26585
P08581-308-unknown	STKKEV...	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26852
P08581-308-unknown	STKKEV...	308	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9722
P08581-308-unknown	STKKEV...	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150068
P08581-308-unknown	STKKEV...	308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150069

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KRKKRS	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27144
...KRKKRS	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26997
...KRKKRS	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27296
...KRKKRS	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26585
...KRKKRS	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26852
...KRKKRS	307	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9722
...KRKKRS	307	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133460
...KRKKRS	307	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133461
...FWETS	1390	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FWETS	1390	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76566

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK6_HUMAN	307	KKRS.\|.STKK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	307	KKRS.\|.STKK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	307	KKRS.\|.STKK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	307	KKRS.\|.STKK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	307	KKRS.\|.STKK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	307	KKRS.\|.STKK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)