P46531: Neurogenic locus notch homolog protein 1

General Information

Protein names	- Neurogenic locus notch homolog protein 1 - Notch 1 - hN1 - Translocation-associated notch protein TAN-1 - Notch 1 extracellular truncation - NEXT - Notch 1 intracellular domain - NICD
Gene names	NOTCH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P46531

17 N-termini

15 C-termini

19 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPPLLAPLLC LALLPALAAR GPRCSQPGET CLNGGKCEAA NGTEACVCGG AFVGPRCQDP
        70         80         90        100        110        120
NPCLSTPCKN AGTCHVVDRR GVADYACSCA LGFSGPLCLT PLDNACLTNP CRNGGTCDLL
       130        140        150        160        170        180
TLTEYKCRCP PGWSGKSCQQ ADPCASNPCA NGGQCLPFEA SYICHCPPSF HGPTCRQDVN
       190        200        210        220        230        240
ECGQKPGLCR HGGTCHNEVG SYRCVCRATH TGPNCERPYV PCSPSPCQNG GTCRPTGDVT
       250        260        270        280        290        300
HECACLPGFT GQNCEENIDD CPGNNCKNGG ACVDGVNTYN CRCPPEWTGQ YCTEDVDECQ
       310        320        330        340        350        360
LMPNACQNGG TCHNTHGGYN CVCVNGWTGE DCSENIDDCA SAACFHGATC HDRVASFYCE
       370        380        390        400        410        420
CPHGRTGLLC HLNDACISNP CNEGSNCDTN PVNGKAICTC PSGYTGPACS QDVDECSLGA
       430        440        450        460        470        480
NPCEHAGKCI NTLGSFECQC LQGYTGPRCE IDVNECVSNP CQNDATCLDQ IGEFQCICMP
       490        500        510        520        530        540
GYEGVHCEVN TDECASSPCL HNGRCLDKIN EFQCECPTGF TGHLCQYDVD ECASTPCKNG
       550        560        570        580        590        600
AKCLDGPNTY TCVCTEGYTG THCEVDIDEC DPDPCHYGSC KDGVATFTCL CRPGYTGHHC
       610        620        630        640        650        660
ETNINECSSQ PCRHGGTCQD RDNAYLCFCL KGTTGPNCEI NLDDCASSPC DSGTCLDKID
       670        680        690        700        710        720
GYECACEPGY TGSMCNINID ECAGNPCHNG GTCEDGINGF TCRCPEGYHD PTCLSEVNEC
       730        740        750        760        770        780
NSNPCVHGAC RDSLNGYKCD CDPGWSGTNC DINNNECESN PCVNGGTCKD MTSGYVCTCR
       790        800        810        820        830        840
EGFSGPNCQT NINECASNPC LNQGTCIDDV AGYKCNCLLP YTGATCEVVL APCAPSPCRN
       850        860        870        880        890        900
GGECRQSEDY ESFSCVCPTG WQGQTCEVDI NECVLSPCRH GASCQNTHGG YRCHCQAGYS
       910        920        930        940        950        960
GRNCETDIDD CRPNPCHNGG SCTDGINTAF CDCLPGFRGT FCEEDINECA SDPCRNGANC
       970        980        990       1000       1010       1020
TDCVDSYTCT CPAGFSGIHC ENNTPDCTES SCFNGGTCVD GINSFTCLCP PGFTGSYCQH
      1030       1040       1050       1060       1070       1080
DVNECDSQPC LHGGTCQDGC GSYRCTCPQG YTGPNCQNLV HWCDSSPCKN GGKCWQTHTQ
      1090       1100       1110       1120       1130       1140
YRCECPSGWT GLYCDVPSVS CEVAAQRQGV DVARLCQHGG LCVDAGNTHH CRCQAGYTGS
      1150       1160       1170       1180       1190       1200
YCEDLVDECS PSPCQNGATC TDYLGGYSCK CVAGYHGVNC SEEIDECLSH PCQNGGTCLD
      1210       1220       1230       1240       1250       1260
LPNTYKCSCP RGTQGVHCEI NVDDCNPPVD PVSRSPKCFN NGTCVDQVGG YSCTCPPGFV
      1270       1280       1290       1300       1310       1320
GERCEGDVNE CLSNPCDARG TQNCVQRVND FHCECRAGHT GRRCESVING CKGKPCKNGG
      1330       1340       1350       1360       1370       1380
TCAVASNTAR GFICKCPAGF EGATCENDAR TCGSLRCLNG GTCISGPRSP TCLCLGPFTG
      1390       1400       1410       1420       1430       1440
PECQFPASSP CLGGNPCYNQ GTCEPTSESP FYRCLCPAKF NGLLCHILDY SFGGGAGRDI
      1450       1460       1470       1480       1490       1500
PPPLIEEACE LPECQEDAGN KVCSLQCNNH ACGWDGGDCS LNFNDPWKNC TQSLQCWKYF
      1510       1520       1530       1540       1550       1560
SDGHCDSQCN SAGCLFDGFD CQRAEGQCNP LYDQYCKDHF SDGHCDQGCN SAECEWDGLD
      1570       1580       1590       1600       1610       1620
CAEHVPERLA AGTLVVVVLM PPEQLRNSSF HFLRELSRVL HTNVVFKRDA HGQQMIFPYY
      1630       1640       1650       1660       1670       1680
GREEELRKHP IKRAAEGWAA PDALLGQVKA SLLPGGSEGG RRRRELDPMD VRGSIVYLEI
      1690       1700       1710       1720       1730       1740
DNRQCVQASS QCFQSATDVA AFLGALASLG SLNIPYKIEA VQSETVEPPP PAQLHFMYVA
      1750       1760       1770       1780       1790       1800
AAAFVLLFFV GCGVLLSRKR RRQHGQLWFP EGFKVSEASK KKRREPLGED SVGLKPLKNA
      1810       1820       1830       1840       1850       1860
SDGALMDDNQ NEWGDEDLET KKFRFEEPVV LPDLDDQTDH RQWTQQHLDA ADLRMSAMAP
      1870       1880       1890       1900       1910       1920
TPPQGEVDAD CMDVNVRGPD GFTPLMIASC SGGGLETGNS EEEEDAPAVI SDFIYQGASL
      1930       1940       1950       1960       1970       1980
HNQTDRTGET ALHLAARYSR SDAAKRLLEA SADANIQDNM GRTPLHAAVS ADAQGVFQIL
      1990       2000       2010       2020       2030       2040
IRNRATDLDA RMHDGTTPLI LAARLAVEGM LEDLINSHAD VNAVDDLGKS ALHWAAAVNN
      2050       2060       2070       2080       2090       2100
VDAAVVLLKN GANKDMQNNR EETPLFLAAR EGSYETAKVL LDHFANRDIT DHMDRLPRDI
      2110       2120       2130       2140       2150       2160
AQERMHHDIV RLLDEYNLVR SPQLHGAPLG GTPTLSPPLC SPNGYLGSLK PGVQGKKVRK
      2170       2180       2190       2200       2210       2220
PSSKGLACGS KEAKDLKARR KKSQDGKGCL LDSSGMLSPV DSLESPHGYL SDVASPPLLP
      2230       2240       2250       2260       2270       2280
SPFQQSPSVP LNHLPGMPDT HLGIGHLNVA AKPEMAALGG GGRLAFETGP PRLSHLPVAS
      2290       2300       2310       2320       2330       2340
GTSTVLGSSS GGALNFTVGG STSLNGQCEW LSRLQSGMVP NQYNPLRGSV APGPLSTQAP
      2350       2360       2370       2380       2390       2400
SLQHGMVGPL HSSLAASALS QMMSYQGLPS TRLATQPHLV QTQQVQPQNL QMQQQNLQPA
      2410       2420       2430       2440       2450       2460
NIQQQQSLQP PPPPPQPHLG VSSAASGHLG RSFLSGEPSQ ADVQPLGPSS LAVHTILPQE
      2470       2480       2490       2500       2510       2520
SPALPTSLPS SLVPPVTAAQ FLTPPSQHSY SSPVDNTPSH QLQVPEHPFL TPSPESPDQW
      2530       2540       2550
SSSSPHSNVS DWSEGVSSPP TSMQSQIARI PEAFK

Isoforms

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Protein Neighborhood

Domains & Features

17 N-termini - 15 C-termini - 19 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P46531-19-unknown	ARGPRC...	19	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46531-1665-unknown	ELDPMD...	1665	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26625
P46531-1665-unknown	ELDPMD...	1665	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26895
P46531-1665-unknown	ELDPMD...	1665	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27193
P46531-1665-unknown	ELDPMD...	1665	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27042
P46531-1665-unknown	ELDPMD...	1665	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27339
P46531-1721-unknown	VQSETV...	1721	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46531-1754-unknown	VLLSRK...	1754	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46531-1754-unknown	VLLSRK...	1754	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31563
P46531-1754-unknown	VLLSRK...	1754	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC139
P46531-1757-unknown	SRKRRR...	1757	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC605
P46531-1757-unknown	SRKRRR...	1757	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46531-1758-unknown	RKRRRQ...	1758	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC606
P46531-1834-unknown	LDDQTD...	1834	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11530
P46531-1840-unknown	HRQWTQ...	1840	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1852
P46531-1871-unknown	CMDVNV...	1871	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11531
P46531-1874-unknown	VNVRGP...	1874	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2557
P46531-1906-unknown	APAVIS...	1906	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2558
P46531-1913-unknown	FIYQGA...	1913	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11532
P46531-1973-unknown	AQGVFQ...	1973	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11533
P46531-2083-unknown	HFANRD...	2083	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11534
P46531-2095-unknown	RLPRDI...	2095	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2559
P46531-2193-unknown	SSGMLS...	2193	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2560
P46531-2407-	SLQPPP...	2407		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46531-2407-	SLQPPP...	2407		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GRRRRE	1664	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26625
...GRRRRE	1664	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26895
...GRRRRE	1664	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27193
...GRRRRE	1664	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27042
...GRRRRE	1664	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27339
...FVGCGV	1753	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31563
...FVGCGV	1753	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC139
...CGVLLS	1756	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC605
...GVLLSR	1757	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC606
...VVLPDL	1833	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11530
...DDQTDH	1839	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1852
...EVDADC	1870	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11531
...ADCMDV	1873	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2557
...EEEEDA	1905	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2558
...AVISDF	1912	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11532
...AVSADA	1972	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11533
...KVLLDH	2082	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11534
...TDHMDR	2094	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2559
...GCLLDS	2192	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2560
...PEAFK	2555	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_HUMAN	1664	RRRE.\|.ELDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	1664	RRRE.\|.ELDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	1664	RRRE.\|.ELDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	1664	RRRE.\|.ELDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	1664	RRRE.\|.ELDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PSN1_HUMAN	1753	GCGV.\|.VLLS	inferred from experiment	unknown	MEROPS	Kim TW	Lee HJ et al.:Presenilin-dependent gamma-secr... (A22.001)	11741961,
ADA17_HUMAN	1753	GCGV.\|.VLLS	inferred from experiment	unknown	MEROPS		Merops ADA17_HUMAN -> NOTC1_HUMAN @1753
BACE2_HUMAN	1756	VLLS.\|.SRKR	inferred from experiment	unknown	MEROPS	Lin X	Kim YT et al.:Enzymic properties of recombina... (A01.041)	12423367,
BACE2_HUMAN	1757	LLSR.\|.RKRR	inferred from experiment	unknown	MEROPS	Lin X	Kim YT et al.:Enzymic properties of recombina... (A01.041)	12423367,
GRAB_HUMAN	1833	LPDL.\|.LDDQ	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,
CASP3_HUMAN	1839	QTDH.\|.HRQW	inferred from experiment	unknown	MEROPS	Sekaly RP	Cohen LY et al.:Notch1 antiapoptotic activity i... (C14.003)	15650752,
GRAB_HUMAN	1870	DADC.\|.CMDV	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,
CASP6_HUMAN	1873	CMDV.\|.VNVR	inferred from experiment	unknown	MEROPS	Sekaly RP	Cohen LY et al.:Notch1 antiapoptotic activity i... (C14.003)	15650752,
CASP6_HUMAN	1905	EEDA.\|.APAV	inferred from experiment	unknown	MEROPS	Sekaly RP	Cohen LY et al.:Notch1 antiapoptotic activity i... (C14.003)	15650752,
GRAB_HUMAN	1912	ISDF.\|.FIYQ	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,
GRAB_HUMAN	1972	SADA.\|.AQGV	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,
GRAB_HUMAN	2082	LLDH.\|.HFAN	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,
CASP6_HUMAN	2094	HMDR.\|.RLPR	inferred from experiment	unknown	MEROPS	Sekaly RP	Cohen LY et al.:Notch1 antiapoptotic activity i... (C14.003)	15650752,
CASP6_HUMAN	2192	LLDS.\|.SSGM	inferred from experiment	unknown	MEROPS	Sekaly RP	Cohen LY et al.:Notch1 antiapoptotic activity i... (C14.003)	15650752,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)