P49768: Presenilin-1

General Information

Protein names	- Presenilin-1 - PS-1 - 3.4.23.- {ECO:0000269\|PubMed:10206644, ECO:0000269\|PubMed:10811883, ECO:0000269\|PubMed:10899933, ECO:0000269\|PubMed:12679784, ECO:0000269\|PubMed:15274632, ECO:0000269\|PubMed:26280335} - Protein S182 - Presenilin-1 NTF subunit - Presenilin-1 CTF subunit - Presenilin-1 CTF12 - PS1-CTF12
Gene names	PSEN1
Organism	Homo sapiens
Protease Family	A22.001
Protease ID	A22.001
Chromosome location
UniProt ID	P49768

4 N-termini

4 C-termini

7 Cleavages

57 Substrates

Sequence

Isoforms

- Isoform 2 of Presenilin-1 - Isoform 3 of Presenilin-1 - Isoform 4 of Presenilin-1 - Isoform 5 of Presenilin-1 - Isoform 6 of Presenilin-1 - Isoform 7 of Presenilin-1

Sequence View

        10         20         30         40         50         60
MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR
        70         80         90        100        110        120
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE
       130        140        150        160        170        180
DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI
       190        200        210        220        230        240
YLGEVFKTYN VAVDYITVAL LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY
       250        260        270        280        290        300
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
       310        320        330        340        350        360
GDPEAQRRVS KNSKYNAEST ERESQDTVAE NDDGGFSEEW EAQRDSHLGP HRSTPESRAA
       370        380        390        400        410        420
VQELSSSILA GEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL
       430        440        450        460
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI         10         20         30         40         50         60
MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR
        70         80         90        100        110        120
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE
       130        140        150        160        170        180
DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI
       190        200        210        220        230        240
YLGEVFKTYN VAVDYITVAL LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY
       250        260        270        280        290        300
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
       310        320        330        340        350        360
GDPEAQRRVS KNSKYNAEST ERESQDTVAE NDDGGFSEEW EAQRDSHLGP HRSTPESRAA
       370        380        390        400        410        420
VQELSSSILA GEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL
       430        440        450        460
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI         10         20         30         40         50         60
MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR
        70         80         90        100        110        120
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE
       130        140        150        160        170        180
DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI
       190        200        210        220        230        240
YLGEVFKTYN VAVDYITVAL LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY
       250        260        270        280        290        300
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
       310        320        330        340        350        360
GDPEAQRRVS KNSKYNAEST ERESQDTVAE NDDGGFSEEW EAQRDSHLGP HRSTPESRAA
       370        380        390        400        410        420
VQELSSSILA GEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL
       430        440        450        460
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI         10         20         30         40         50         60
MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR
        70         80         90        100        110        120
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE
       130        140        150        160        170        180
DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI
       190        200        210        220        230        240
YLGEVFKTYN VAVDYITVAL LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY
       250        260        270        280        290        300
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
       310        320        330        340        350        360
GDPEAQRRVS KNSKYNAEST ERESQDTVAE NDDGGFSEEW EAQRDSHLGP HRSTPESRAA
       370        380        390        400        410        420
VQELSSSILA GEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL
       430        440        450        460
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI         10         20         30         40         50         60
MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR
        70         80         90        100        110        120
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE
       130        140        150        160        170        180
DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI
       190        200        210        220        230        240
YLGEVFKTYN VAVDYITVAL LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY
       250        260        270        280        290        300
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
       310        320        330        340        350        360
GDPEAQRRVS KNSKYNAEST ERESQDTVAE NDDGGFSEEW EAQRDSHLGP HRSTPESRAA
       370        380        390        400        410        420
VQELSSSILA GEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL
       430        440        450        460
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI         10         20         30         40         50         60
MTELPAPLSY FQNAQMSEDN HLSNTVRSQN DNRERQEHND RRSLGHPEPL SNGRPQGNSR
        70         80         90        100        110        120
QVVEQDEEED EELTLKYGAK HVIMLFVPVT LCMVVVVATI KSVSFYTRKD GQLIYTPFTE
       130        140        150        160        170        180
DTETVGQRAL HSILNAAIMI SVIVVMTILL VVLYKYRCYK VIHAWLIISS LLLLFFFSFI
       190        200        210        220        230        240
YLGEVFKTYN VAVDYITVAL LIWNFGVVGM ISIHWKGPLR LQQAYLIMIS ALMALVFIKY
       250        260        270        280        290        300
LPEWTAWLIL AVISVYDLVA VLCPKGPLRM LVETAQERNE TLFPALIYSS TMVWLVNMAE
       310        320        330        340        350        360
GDPEAQRRVS KNSKYNAEST ERESQDTVAE NDDGGFSEEW EAQRDSHLGP HRSTPESRAA
       370        380        390        400        410        420
VQELSSSILA GEDPEERGVK LGLGDFIFYS VLVGKASATA SGDWNTTIAC FVAILIGLCL
       430        440        450        460
TLLLLAIFKK ALPALPISIT FGLVFYFATD YLVQPFMDQL AFHQFYI

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 7 Cleavages - 57 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49768-1-unknown	MTELPA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49768-1-unknown	MTELPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86413
P49768-1-unknown	MTELPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86414
P49768-1-unknown	MTELPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86415
P49768-1-unknown	MTELPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86416
P49768-1-unknown	MTELPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86417
P49768-1-unknown	MTELPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86418
P49768-299-unknown	AEGDPE...	299	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49768-299-unknown	AEGDPE...	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116131
P49768-299-unknown	AEGDPE...	299	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116132
P49768-334-unknown	GGFSEE...	334	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3077
P49768-334-unknown	GGFSEE...	334	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2568
P49768-334-unknown	GGFSEE...	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149878
P49768-334-unknown	GGFSEE...	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150519
P49768-346-unknown	SHLGPH...	346	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49768-346-unknown	SHLGPH...	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3080
P49768-346-unknown	SHLGPH...	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2571
P49768-346-unknown	SHLGPH...	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2861
P49768-346-unknown	SHLGPH...	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1885
P49768-346-unknown	SHLGPH...	346	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1228
P49768-346-unknown	SHLGPH...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116167
P49768-346-unknown	SHLGPH...	346	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116168

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WLVNMA	298	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WLVNMA	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92284
...WLVNMA	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92285
...WLVNMA	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92282
...WLVNMA	298	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92283
...AENDDG	333	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3077
...AENDDG	333	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2568
...AENDDG	333	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133269
...AENDDG	333	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133915
...EAQRDS	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3080
...EAQRDS	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2571
...EAQRDS	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2861
...EAQRDS	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1885
...EAQRDS	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1228
...EAQRDS	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133565
...EAQRDS	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134172
...HQFYI	467	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HQFYI	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82035
...HQFYI	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82036
...HQFYI	467	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82031

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP8_HUMAN	333	NDDG.\|.GGFS	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP6_HUMAN	333	NDDG.\|.GGFS	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP8_HUMAN	345	QRDS.\|.SHLG	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP6_HUMAN	345	QRDS.\|.SHLG	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP7_HUMAN	345	QRDS.\|.SHLG	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP3_HUMAN	345	QRDS.\|.SHLG	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,
CASP1_HUMAN	345	QRDS.\|.SHLG	inferred from experiment	unknown	MEROPS	Vandenabeele P	van de Craen M et al.:Identification of caspases that... (C14.001)	10069390,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CD44-Isoform18_HUMAN	257	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform15_HUMAN	278	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform12_HUMAN	278	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform14_HUMAN	313	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform13_HUMAN	342	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform11_HUMAN	346	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
SDC3_HUMAN	403	AFLV.\|.VTLL	inferred from experiment	unknown	MEROPS	David G	Schulz JG et al.:Syndecan 3 intramembrane proteo... (A22.001)	14504279,
SDC3_HUMAN	404	FLVT.\|.TLLI	inferred from experiment	unknown	MEROPS	David G	Schulz JG et al.:Syndecan 3 intramembrane proteo... (A22.001)	14504279,
SDC3_HUMAN	405	LVTL.\|.LLIY	inferred from experiment	unknown	MEROPS	David G	Schulz JG et al.:Syndecan 3 intramembrane proteo... (A22.001)	14504279,
SDC3_HUMAN	406	VTLL.\|.LIYR	inferred from experiment	unknown	MEROPS	David G	Schulz JG et al.:Syndecan 3 intramembrane proteo... (A22.001)	14504279,
CD44-Isoform10_HUMAN	410	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
A4-Isoform10_HUMAN	580	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform10_HUMAN	582	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform10_HUMAN	583	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
CD44-Isoform16_HUMAN	585	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform8_HUMAN	591	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform17_HUMAN	608	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform6_HUMAN	616	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform4_HUMAN	616	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
A4-Isoform3_HUMAN	618	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform3_HUMAN	620	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform3_HUMAN	621	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
CD44-Isoform3_HUMAN	628	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
CD44-Isoform7_HUMAN	630	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
A4-Isoform4_HUMAN	636	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform5_HUMAN	637	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform4_HUMAN	638	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform5_HUMAN	639	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform4_HUMAN	639	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
A4-Isoform5_HUMAN	640	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
CD44-Isoform5_HUMAN	651	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
A4-Isoform6_HUMAN	655	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform6_HUMAN	657	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform6_HUMAN	658	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
CD44_HUMAN	659	LLAL.\|.LALI	inferred from experiment	unknown	MEROPS	Haass C	Lammich S et al.:Presenilin-dependent intramembr... (A22.001)	12223485,
CD44-Isoform9_HUMAN	659	LLAL.\|.LALI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31546
ERBB4-Isoform4_HUMAN	662	TFAV.\|.VYVR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31564
ERBB4-Isoform2_HUMAN	662	TFAV.\|.VYVR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31564
ERBB4_HUMAN	672	TFAV.\|.VYVR	inferred from experiment	unknown	MEROPS	Kim TW	Lee HJ et al.:Presenilin-dependent gamma-secr... (A22.001)	11741961,
ERBB4-Isoform3_HUMAN	672	TFAV.\|.VYVR	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31564
A4-Isoform7_HUMAN	674	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform7_HUMAN	676	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform7_HUMAN	677	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
A4-Isoform11_HUMAN	687	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform11_HUMAN	689	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform11_HUMAN	690	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
A4-Isoform8_HUMAN	692	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform9_HUMAN	693	GVVI.\|.IATV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31515
A4-Isoform8_HUMAN	694	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform9_HUMAN	695	VIAT.\|.TVIV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31525
A4-Isoform8_HUMAN	695	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
A4-Isoform9_HUMAN	696	IATV.\|.VIVI	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC31535
A4_HUMAN	711	GVVI.\|.IATV	inferred from experiment	unknown	MEROPS	Van Leuven F	De Strooper B et al.:Deficiency of presenilin-1 inhi... (A22.001)	9450754,
A4_HUMAN	713	VIAT.\|.TVIV	inferred from experiment	unknown	MEROPS	Van Leuven F	De Strooper B et al.:Deficiency of presenilin-1 inhi... (A22.001)	9450754,
A4_HUMAN	714	IATV.\|.VIVI	inferred from experiment	unknown	MEROPS	Van Leuven F	De Strooper B et al.:Deficiency of presenilin-1 inhi... (A22.001)	9450754,
CADH1_HUMAN	731	LFLR.\|.RRRA	inferred from experiment	unknown	MEROPS	Wolfe MS	Xia W et al.:Intramembrane proteolysis by pr... (A22.001)	12808018,
NOTC1_HUMAN	1753	GCGV.\|.VLLS	inferred from experiment	unknown	MEROPS	Kim TW	Lee HJ et al.:Presenilin-dependent gamma-secr... (A22.001)	11741961,