Q15303: Receptor tyrosine-protein kinase erbB-4

General Information

Protein names	- Receptor tyrosine-protein kinase erbB-4 - 2.7.10.1 - Proto-oncogene-like protein c-ErbB-4 - Tyrosine kinase-type cell surface receptor HER4 - p180erbB4 - ERBB4 intracellular domain - 4ICD - E4ICD - s80HER4
Gene names	ERBB4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15303

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform JM-B CYT-1 of Receptor tyrosine-protein kinase erbB-4 - Isoform JM-A CYT-2 of Receptor tyrosine-protein kinase erbB-4 - Isoform JM-B CYT-2 of Receptor tyrosine-protein kinase erbB-4

Sequence View

        10         20         30         40         50         60
MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM
        70         80         90        100        110        120
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF
       130        140        150        160        170        180
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST
       190        200        210        220        230        240
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG
       250        260        270        280        290        300
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD
       310        320        330        340        350        360
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT
       370        380        390        400        410        420
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL
       430        440        450        460        470        480
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST
       490        500        510        520        530        540
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD
       550        560        570        580        590        600
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA
       610        620        630        640        650        660
NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG
       670        680        690        700        710        720
LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR
       730        740        750        760        770        780
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL
       790        800        810        820        830        840
VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV
       850        860        870        880        890        900
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ
       910        920        930        940        950        960
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID
       970        980        990       1000       1010       1020
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE
      1030       1040       1050       1060       1070       1080
EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP
      1090       1100       1110       1120       1130       1140
YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS
      1150       1160       1170       1180       1190       1200
PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED
      1210       1220       1230       1240       1250       1260
EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ
      1270       1280       1290       1300
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV         10         20         30         40         50         60
MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM
        70         80         90        100        110        120
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF
       130        140        150        160        170        180
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST
       190        200        210        220        230        240
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG
       250        260        270        280        290        300
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD
       310        320        330        340        350        360
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT
       370        380        390        400        410        420
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL
       430        440        450        460        470        480
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST
       490        500        510        520        530        540
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD
       550        560        570        580        590        600
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA
       610        620        630        640        650        660
NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG
       670        680        690        700        710        720
LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR
       730        740        750        760        770        780
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL
       790        800        810        820        830        840
VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV
       850        860        870        880        890        900
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ
       910        920        930        940        950        960
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID
       970        980        990       1000       1010       1020
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE
      1030       1040       1050       1060       1070       1080
EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP
      1090       1100       1110       1120       1130       1140
YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS
      1150       1160       1170       1180       1190       1200
PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED
      1210       1220       1230       1240       1250       1260
EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ
      1270       1280       1290       1300
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV         10         20         30         40         50         60
MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM
        70         80         90        100        110        120
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF
       130        140        150        160        170        180
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST
       190        200        210        220        230        240
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG
       250        260        270        280        290        300
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD
       310        320        330        340        350        360
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT
       370        380        390        400        410        420
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL
       430        440        450        460        470        480
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST
       490        500        510        520        530        540
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD
       550        560        570        580        590        600
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA
       610        620        630        640        650        660
NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG
       670        680        690        700        710        720
LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR
       730        740        750        760        770        780
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL
       790        800        810        820        830        840
VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV
       850        860        870        880        890        900
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ
       910        920        930        940        950        960
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID
       970        980        990       1000       1010       1020
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE
      1030       1040       1050       1060       1070       1080
EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP
      1090       1100       1110       1120       1130       1140
YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS
      1150       1160       1170       1180       1190       1200
PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED
      1210       1220       1230       1240       1250       1260
EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ
      1270       1280       1290       1300
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q15303-1-unknown	MKPATG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74098
Q15303-1-unknown	MKPATG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74099
Q15303-1-unknown	MKPATG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74100
Q15303-26-unknown	QSVCAG...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q15303-26-unknown	QSVCAG...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114039
Q15303-26-unknown	QSVCAG...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114040
Q15303-26-unknown	QSVCAG...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114041
Q15303-642-unknown	STLPQH...	642	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC140
Q15303-642-unknown	STLPQH...	642	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155219
Q15303-673-unknown	VYVRRK...	673	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31564
Q15303-673-unknown	VYVRRK...	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155446
Q15303-673-unknown	VYVRRK...	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155447
Q15303-673-unknown	VYVRRK...	673	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155581
Q15303-676-unknown	RRKSIK...	676	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q15303-676-unknown	RRKSIK...	676	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116284
Q15303-676-unknown	RRKSIK...	676	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116286
Q15303-676-unknown	RRKSIK...	676	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116285

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PWTGHS	641	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC140
...PWTGHS	641	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138650
...GLTFAV	672	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31564
...GLTFAV	672	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138880
...GLTFAV	672	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138881
...GLTFAV	672	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139021
...RNTVV	1308	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RNTVV	1308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69718
...RNTVV	1308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69717
...RNTVV	1308	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69716

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ADA17_HUMAN	641	TGHS.\|.STLP	inferred from experiment	unknown	MEROPS	Carpenter G	Cheng QC et al.:Ectodomain cleavage of ErbB-4: ... (M12.217)	12869563,
PSN1_HUMAN	672	TFAV.\|.VYVR	inferred from experiment	unknown	MEROPS	Kim TW	Lee HJ et al.:Presenilin-dependent gamma-secr... (A22.001)	11741961,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)