TopFIND 4.0

P78536: Disintegrin and metalloproteinase domain-containing protein 17

General Information

Protein names
- Disintegrin and metalloproteinase domain-containing protein 17
- ADAM 17
- 3.4.24.86 {ECO:0000269|PubMed:12441351, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:24227843}
- Snake venom-like protease
- TNF-alpha convertase
- TNF-alpha-converting enzyme
- CD156b
Gene names ADAM17
Organism Homo sapiens
Protease Family M12.217
Protease ID M12.217
Chromosome location
UniProt ID P78536

3

N-termini

3

C-termini

5

Cleavages

48

Substrates

Sequence

        10         20         30         40         50         60 
MRQSLLFLTS VVPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI QQHSVRKRDL 
        70         80         90        100        110        120 
QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKVVVVD GKNESEYTVK WQDFFTGHVV 
       130        140        150        160        170        180 
GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS 
       190        200        210        220        230        240 
PKVCGYLKVD NEELLPKGLV DREPPEELVH RVKRRADPDP MKNTCKLLVV ADHRFYRYMG 
       250        260        270        280        290        300 
RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM 
       310        320        330        340        350        360 
AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 
       370        380        390        400        410        420 
HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 
       430        440        450        460        470        480 
AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 
       490        500        510        520        530        540 
SRVDEGEECD PGIMYLNNDT CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA 
       550        560        570        580        590        600 
TCKGVSYCTG NSSECPPPGN AEDDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC 
       610        620        630        640        650        660 
KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 
       670        680        690        700        710        720 
INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHP SNVEMLSSMD 
       730        740        750        760        770        780 
SASVRIIKPF PAPQTPGRLQ PAPVIPSAPA APKLDHQRMD TIQEDPSTDS HMDEDGFEKD 
       790        800        810        820    
PFPNSSTAAK SFEDLTDHPV TRSEKAASFK LQRQNRVDSK ETEC

Isoforms

- Isoform B of Disintegrin and metalloproteinase domain-containing protein 17

Sequence View

        10         20         30         40         50         60 
MRQSLLFLTS VVPFVLAPRP PDDPGFGPHQ RLEKLDSLLS DYDILSLSNI QQHSVRKRDL 
        70         80         90        100        110        120 
QTSTHVETLL TFSALKRHFK LYLTSSTERF SQNFKVVVVD GKNESEYTVK WQDFFTGHVV 
       130        140        150        160        170        180 
GEPDSRVLAH IRDDDVIIRI NTDGAEYNIE PLWRFVNDTK DKRMLVYKSE DIKNVSRLQS 
       190        200        210        220        230        240 
PKVCGYLKVD NEELLPKGLV DREPPEELVH RVKRRADPDP MKNTCKLLVV ADHRFYRYMG 
       250        260        270        280        290        300 
RGEESTTTNY LIELIDRVDD IYRNTSWDNA GFKGYGIQIE QIRILKSPQE VKPGEKHYNM 
       310        320        330        340        350        360 
AKSYPNEEKD AWDVKMLLEQ FSFDIAEEAS KVCLAHLFTY QDFDMGTLGL AYVGSPRANS 
       370        380        390        400        410        420 
HGGVCPKAYY SPVGKKNIYL NSGLTSTKNY GKTILTKEAD LVTTHELGHN FGAEHDPDGL 
       430        440        450        460        470        480 
AECAPNEDQG GKYVMYPIAV SGDHENNKMF SNCSKQSIYK TIESKAQECF QERSNKVCGN 
       490        500        510        520        530        540 
SRVDEGEECD PGIMYLNNDT CCNSDCTLKE GVQCSDRNSP CCKNCQFETA QKKCQEAINA 
       550        560        570        580        590        600 
TCKGVSYCTG NSSECPPPGN AEDDTVCLDL GKCKDGKCIP FCEREQQLES CACNETDNSC 
       610        620        630        640        650        660 
KVCCRDLSGR CVPYVDAEQK NLFLRKGKPC TVGFCDMNGK CEKRVQDVIE RFWDFIDQLS 
       670        680        690        700        710        720 
INTFGKFLAD NIVGSVLVFS LIFWIPFSIL VHCVDKKLDK QYESLSLFHP SNVEMLSSMD 
       730        740        750        760        770        780 
SASVRIIKPF PAPQTPGRLQ PAPVIPSAPA APKLDHQRMD TIQEDPSTDS HMDEDGFEKD 
       790        800        810        820    
PFPNSSTAAK SFEDLTDHPV TRSEKAASFK LQRQNRVDSK ETEC



Filter Information:


(REFRESH)

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 5 Cleavages - 48 Substrates

N-termini

C-termini

Cleavages

Substrates