P15514: Amphiregulin {ECO:0000303|PubMed:2325643}
| Protein names | - Amphiregulin {ECO:0000303|PubMed:2325643} - AR {ECO:0000303|PubMed:2325643} - Colorectum cell-derived growth factor {ECO:0000303|PubMed:1333777} - CRDGF {ECO:0000303|PubMed:1333777} |
|---|---|
| Gene names | AREGB |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P15514 |
4
N-termini
2
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MRAPLLPPAP VVLSLLILGS GHYAAGLDLN DTYSGKREPF SGDHSADGFE VTSRSEMSSG
70 80 90 100 110 120
SEISPVSEMP SSSEPSSGAD YDYSEEYDNE PQIPGYIVDD SVRVEQVVKP PQNKTESENT
130 140 150 160 170 180
SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER
190 200 210 220 230 240
CGEKSMKTHS MIDSSLSKIA LAAIAAFMSA VILTAVAVIT VQLRRQYVRK YEGEAEERKK
250
LRQENGNVHA IA
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P15514-20-unknown | SGHYAA... | 20 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P15514-101-unknown | SVRVEQ... | 101 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P15514-107-unknown | VVKPPQ... | 107 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC136 | |||
| P15514-188-unknown | THSMID... | 188 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC137 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...VRVEQV | 106 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC136 | |||
| ...EKSMKT | 187 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...EKSMKT | 187 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC137 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ADA17_HUMAN | 106 | VEQV.|.VVKP | inferred from experiment | unknown | MEROPS | Lee DC | Hinkle CL et al.:Selective roles for tumor necro... (M12.217) | 15066986, |
| ADA17_HUMAN | 187 | SMKT.|.THSM | inferred from experiment | unknown | MEROPS | Lee DC | Hinkle CL et al.:Selective roles for tumor necro... (M12.217) | 15066986, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|