Q99075: Proheparin-binding EGF-like growth factor

General Information

Protein names	- Proheparin-binding EGF-like growth factor - Heparin-binding EGF-like growth factor - HB-EGF - HBEGF - Diphtheria toxin receptor - DT-R
Gene names	HBEGF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99075

8 N-termini

9 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNP DPPTVSTDQL LPLGGGRDRK
        70         80         90        100        110        120
VRDLQEADLD LLRVTLSSKP QALATPNKEE HGKRKKKGKG LGKKRDPCLR KYKDFCIHGE
       130        140        150        160        170        180
CKYVKELRAP SCICHPGYHG ERCHGLSLPV ENRLYTYDHT TILAVVAVVL SSVCLLVIVG
       190        200
LLMFRYHRRG GYDVENEEKV KLGMTNSH

Isoforms

Sequence View

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Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 9 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99075-20-unknown	LVTGES...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99075-32-unknown	GLAAGT...	32	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC142
Q99075-63-unknown	DLQEAD...	63	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99075-63-unknown	DLQEAD...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26654
Q99075-63-unknown	DLQEAD...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26924
Q99075-63-unknown	DLQEAD...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27222
Q99075-63-unknown	DLQEAD...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9822
Q99075-63-unknown	DLQEAD...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC143
Q99075-63-unknown	DLQEAD...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27074
Q99075-63-unknown	DLQEAD...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27369
Q99075-73-unknown	RVTLSS...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC144
Q99075-74-unknown	VTLSSK...	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC145
Q99075-150-unknown	VENRLY...	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21623
Q99075-150-unknown	VENRLY...	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC146
Q99075-152-unknown	NRLYTY...	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21624
Q99075-152-unknown	NRLYTY...	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23946
Q99075-152-unknown	NRLYTY...	152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21694
Q99075-154-unknown	LYTYDH...	154	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21695

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ERLRRG	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC142
...DRKVRD	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26654
...DRKVRD	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26924
...DRKVRD	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27222
...DRKVRD	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9822
...DRKVRD	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC143
...DRKVRD	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27074
...DRKVRD	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27369
...DLDLLR	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC144
...LDLLRV	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC145
...HGLSLP	148	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLSLPV	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21623
...GLSLPV	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC146
...SLPVEN	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21624
...SLPVEN	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23946
...SLPVEN	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21694
...PVENRL	153	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21695
...MTNSH	208	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ADA17_HUMAN	31	LRRG.\|.GLAA	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
NEC2_HUMAN	62	KVRD.\|.DLQE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	62	KVRD.\|.DLQE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	62	KVRD.\|.DLQE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	62	KVRD.\|.DLQE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
ADA17_HUMAN	62	KVRD.\|.DLQE	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
PCSK5_HUMAN	62	KVRD.\|.DLQE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	62	KVRD.\|.DLQE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
ADA17_HUMAN	72	DLLR.\|.RVTL	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
ADA17_HUMAN	73	LLRV.\|.VTLS	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
MMP14_HUMAN	149	SLPV.\|.VENR	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
ADA17_HUMAN	149	SLPV.\|.VENR	inferred from experiment	unknown	MEROPS	Lee DC	Hinkle CL et al.:Selective roles for tumor necro... (M12.217)	15066986,
MMP14_HUMAN	151	PVEN.\|.NRLY	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
MMP3_HUMAN	151	PVEN.\|.NRLY	inferred from experiment	unknown	MEROPS	Klagsbrun M	Suzuki M et al.:Matrix metalloproteinase-3 rele... (M10.005)	9395517,
MMP17_HUMAN	151	PVEN.\|.NRLY	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
MMP17_HUMAN	153	ENRL.\|.LYTY	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)