P01375: Tumor necrosis factor

General Information

Protein names	- Tumor necrosis factor - Cachectin - TNF-alpha - Tumor necrosis factor ligand superfamily member 2 - TNF-a - Tumor necrosis factor, membrane form - N-terminal fragment - NTF - Intracellular domain 1 - ICD1 - Intracellular domain 2 - ICD2 - C-domain 1 - C-domain 2 - Tumor necrosis factor, soluble form
Gene names	TNF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01375

13 N-termini

15 C-termini

23 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSTESMIRDV ELAEEALPKK TGGPQGSRRC LFLSLFSFLI VAGATTLFCL LHFGVIGPQR
        70         80         90        100        110        120
EEFPRDLSLI SPLAQAVRSS SRTPSDKPVA HVVANPQAEG QLQWLNRRAN ALLANGVELR
       130        140        150        160        170        180
DNQLVVPSEG LYLIYSQVLF KGQGCPSTHV LLTHTISRIA VSYQTKVNLL SAIKSPCQRE
       190        200        210        220        230
TPEGAEAKPW YEPIYLGGVF QLEKGDRLSA EINRPDYLDF AESGQVYFGI IAL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

13 N-termini - 15 C-termini - 23 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01375-1-unknown	MSTESM...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01375-35-unknown	LFSFLI...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31597
P01375-35-unknown	LFSFLI...	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31602
P01375-37-unknown	SFLIVA...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31598
P01375-37-unknown	SFLIVA...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31603
P01375-40-unknown	IVAGAT...	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31599
P01375-40-unknown	IVAGAT...	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31604
P01375-50-unknown	LLHFGV...	50	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01375-50-unknown	LLHFGV...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31600
P01375-50-unknown	LLHFGV...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31605
P01375-52-unknown	HFGVIG...	52	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01375-52-unknown	HFGVIG...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31601
P01375-52-unknown	HFGVIG...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31606
P01375-70-unknown	ISPLAQ...	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21437
P01375-73-unknown	LAQAVR...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21438
P01375-75-unknown	QAVRSS...	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC179
P01375-75-unknown	QAVRSS...	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21439
P01375-75-unknown	QAVRSS...	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC211
P01375-76-unknown	AVRSSS...	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21673
P01375-77-unknown	VRSSSR...	77	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01375-77-unknown	VRSSSR...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC72
P01375-77-unknown	VRSSSR...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC117
P01375-77-unknown	VRSSSR...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC180
P01375-77-unknown	VRSSSR...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21440
P01375-79-unknown	SSSRTP...	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC156
P01375-80-unknown	SSRTPS...	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC157
P01375-80-unknown	SSRTPS...	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC212

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...CLFLSL	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31597
...CLFLSL	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31602
...LFLSLF	35	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FLSLFS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31598
...FLSLFS	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31603
...LFSFLI	39	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LFSFLI	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31599
...LFSFLI	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31604
...TTLFCL	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31600
...TTLFCL	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31605
...LFCLLH	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31601
...LFCLLH	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31606
...RDLSLI	69	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21437
...SLISPL	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21438
...ISPLAQ	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC179
...ISPLAQ	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21439
...ISPLAQ	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC211
...SPLAQA	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21673
...PLAQAV	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC72
...PLAQAV	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC117
...PLAQAV	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC180
...PLAQAV	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21440
...AQAVRS	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC156
...QAVRSS	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC157
...QAVRSS	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC212
...GIIAL	233	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
SPP2A_HUMAN	34	FLSL.\|.LFSF	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007)	19189970,
SPP2B_HUMAN	34	FLSL.\|.LFSF	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:A gamma-secretase-like intramem... (A22.004)	16829951,
SPP2A_HUMAN	36	SLFS.\|.SFLI	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007)	19189970,
SPP2B_HUMAN	36	SLFS.\|.SFLI	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007)	19189970,
SPP2A_HUMAN	39	SFLI.\|.IVAG	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007)	19189970,
SPP2B_HUMAN	39	SFLI.\|.IVAG	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:A gamma-secretase-like intramem... (A22.004)	16829951,
SPP2A_HUMAN	49	LFCL.\|.LLHF	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007)	19189970,
SPP2B_HUMAN	49	LFCL.\|.LLHF	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:A gamma-secretase-like intramem... (A22.004)	16829951,
SPP2A_HUMAN	51	CLLH.\|.HFGV	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007)	19189970,
SPP2B_HUMAN	51	CLLH.\|.HFGV	inferred from experiment	unknown	MEROPS	Haass C	Fluhrer R et al.:A gamma-secretase-like intramem... (A22.004)	16829951,
MMP14_HUMAN	69	LSLI.\|.ISPL	inferred from experiment	unknown	MEROPS	Overall CM	Tam EM et al.:Membrane protease proteomics: I... (M10.014)	15118097,
MMP14_HUMAN	72	ISPL.\|.LAQA	inferred from experiment	unknown	MEROPS	Overall CM	Tam EM et al.:Membrane protease proteomics: I... (M10.014)	15118097,
ADAM8_HUMAN	74	PLAQ.\|.QAVR	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
MMP14_HUMAN	74	PLAQ.\|.QAVR	inferred from experiment	unknown	MEROPS	Overall CM	Tam EM et al.:Membrane protease proteomics: I... (M10.014)	15118097,
ADAM9_HUMAN	74	PLAQ.\|.QAVR	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
MMP17_HUMAN	75	LAQA.\|.AVRS	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
ADA10_HUMAN	76	AQAV.\|.VRSS	inferred from experiment	unknown	MEROPS	Lichenstein HS	Rosendahl MS et al.:Identification and characteriza... (M12.210)	9305925,
ADA17_HUMAN	76	AQAV.\|.VRSS	inferred from experiment	unknown	MEROPS		Merops ADA17_HUMAN -> TNFA_HUMAN @76
ADAM8_HUMAN	76	AQAV.\|.VRSS	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
MMP14_HUMAN	76	AQAV.\|.VRSS	inferred from experiment	unknown	MEROPS	Overall CM	Tam EM et al.:Membrane protease proteomics: I... (M10.014)	15118097,
ADA19_HUMAN	78	AVRS.\|.SSSR	inferred from experiment	unknown	MEROPS	Blobel CP	Chesneau V et al.:Catalytic properties of ADAM19.... (M12.214)	12682046,
ADA19_HUMAN	79	VRSS.\|.SSRT	inferred from experiment	unknown	MEROPS	Blobel CP	Chesneau V et al.:Catalytic properties of ADAM19.... (M12.214)	12682046,
ADAM9_HUMAN	79	VRSS.\|.SSRT	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)