Q13443: Disintegrin and metalloproteinase domain-containing protein 9

General Information

Protein names	- Disintegrin and metalloproteinase domain-containing protein 9 - ADAM 9 - 3.4.24.- - Cellular disintegrin-related protein - Meltrin-gamma - Metalloprotease/disintegrin/cysteine-rich protein 9 - Myeloma cell metalloproteinase
Gene names	ADAM9
Organism	Homo sapiens
Protease Family	M12.209
Protease ID	M12.209
Chromosome location
UniProt ID	Q13443

6 N-termini

5 C-termini

7 Cleavages

12 Substrates

Sequence

        10         20         30         40         50         60
MGSGARFPSG TLRVRWLLLL GLVGPVLGAA RPGFQQTSHL SSYEIITPWR LTRERREAPR
        70         80         90        100        110        120
PYSKQVSYVI QAEGKEHIIH LERNKDLLPE DFVVYTYNKE GTLITDHPNI QNHCHYRGYV
       130        140        150        160        170        180
EGVHNSSIAL SDCFGLRGLL HLENASYGIE PLQNSSHFEH IIYRMDDVYK EPLKCGVSNK
       190        200        210        220        230        240
DIEKETAKDE EEEPPSMTQL LRRRRAVLPQ TRYVELFIVV DKERYDMMGR NQTAVREEMI
       250        260        270        280        290        300
LLANYLDSMY IMLNIRIVLV GLEIWTNGNL INIVGGAGDV LGNFVQWREK FLITRRRHDS
       310        320        330        340        350        360
AQLVLKKGFG GTAGMAFVGT VCSRSHAGGI NVFGQITVET FASIVAHELG HNLGMNHDDG
       370        380        390        400        410        420
RDCSCGAKSC IMNSGASGSR NFSSCSAEDF EKLTLNKGGN CLLNIPKPDE AYSAPSCGNK
       430        440        450        460        470        480
LVDAGEECDC GTPKECELDP CCEGSTCKLK SFAECAYGDC CKDCRFLPGG TLCRGKTSEC
       490        500        510        520        530        540
DVPEYCNGSS QFCQPDVFIQ NGYPCQNNKA YCYNGMCQYY DAQCQVIFGS KAKAAPKDCF
       550        560        570        580        590        600
IEVNSKGDRF GNCGFSGNEY KKCATGNALC GKLQCENVQE IPVFGIVPAI IQTPSRGTKC
       610        620        630        640        650        660
WGVDFQLGSD VPDPGMVNEG TKCGAGKICR NFQCVDASVL NYDCDVQKKC HGHGVCNSNK
       670        680        690        700        710        720
NCHCENGWAP PNCETKGYGG SVDSGPTYNE MNTALRDGLL VFFFLIVPLI VCAIFIFIKR
       730        740        750        760        770        780
DQLWRSYFRK KRSQTYESDG KNQANPSRQP GSVPRHVSPV TPPREVPIYA NRFAVPTYAA
       790        800        810
KQPQQFPSRP PPPQPKVSSQ GNLIPARPAP APPLYSSLT

Isoforms

- Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 9

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 7 Cleavages - 12 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13443-1-unknown	MGSGAR...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66342
Q13443-29-unknown	AARPGF...	29	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13443-29-unknown	AARPGF...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114614
Q13443-72-unknown	AEGKEH...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17906
Q13443-72-unknown	AEGKEH...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19444
Q13443-72-unknown	AEGKEH...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140804
Q13443-73-unknown	EGKEHI...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17908
Q13443-73-unknown	EGKEHI...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19446
Q13443-73-unknown	EGKEHI...	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140860
Q13443-96-unknown	TYNKEG...	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19448
Q13443-96-unknown	TYNKEG...	96	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142220
Q13443-107-unknown	HPNIQN...	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17910
Q13443-107-unknown	HPNIQN...	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19450
Q13443-107-unknown	HPNIQN...	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142786

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SYVIQA	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17906
...SYVIQA	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19444
...SYVIQA	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123942
...YVIQAE	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17908
...YVIQAE	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19446
...YVIQAE	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124000
...DFVVYT	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19448
...DFVVYT	95	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125408
...TLITDH	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17910
...TLITDH	106	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19450
...TLITDH	106	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125990
...YSSLT	819	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	71	VIQA.\|.AEGK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	71	VIQA.\|.AEGK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	72	IQAE.\|.EGKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	72	IQAE.\|.EGKE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	95	VVYT.\|.TYNK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	106	ITDH.\|.HPNI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	106	ITDH.\|.HPNI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TNFA_HUMAN	74	PLAQ.\|.QAVR	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
TNFA_HUMAN	79	VRSS.\|.SSRT	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,
A4-Isoform10_HUMAN	554	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4-Isoform3_HUMAN	592	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4-Isoform4_HUMAN	610	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4-Isoform5_HUMAN	611	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4-Isoform6_HUMAN	629	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4-Isoform7_HUMAN	648	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4-Isoform11_HUMAN	661	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4-Isoform8_HUMAN	666	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4-Isoform9_HUMAN	667	VHHQ.\|.QKLV	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC213
A4_HUMAN	685	VHHQ.\|.QKLV	inferred from experiment	unknown	MEROPS	Murphy G	Amour A et al.:The enzymatic activity of ADAM8... (M12.210)	12135759,