Q8TCT8: Signal peptide peptidase-like 2A {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30227}
| Protein names | - Signal peptide peptidase-like 2A {ECO:0000303|PubMed:15385547, ECO:0000312|HGNC:HGNC:30227} - SPP-like 2A {ECO:0000303|PubMed:15385547} - SPPL2a {ECO:0000303|PubMed:15385547} - 3.4.23.- - Intramembrane protease 3 {ECO:0000303|PubMed:12139484} - IMP-3 {ECO:0000303|PubMed:12139484} - Presenilin-like protein 2 |
|---|---|
| Gene names | SPPL2A |
| Organism | Homo sapiens |
| Protease Family | A22.007 |
| Protease ID | A22.007 |
| Chromosome location | |
| UniProt ID | Q8TCT8 |
2
N-termini
2
C-termini
0
Cleavages
5
Substrates
Sequence
10 20 30 40 50 60
MGPQRRLSPA GAALLWGFLL QLTAAQEAIL HASGNGTTKD YCMLYNPYWT ALPSTLENAT
70 80 90 100 110 120
SISLMNLTST PLCNLSDIPP VGIKSKAVVV PWGSCHFLEK ARIAQKGGAE AMLVVNNSVL
130 140 150 160 170 180
FPPSGNRSEF PDVKILIAFI SYKDFRDMNQ TLGDNITVKM YSPSWPNFDY TMVVIFVIAV
190 200 210 220 230 240
FTVALGGYWS GLVELENLKA VTTEDREMRK KKEEYLTFSP LTVVIFVVIC CVMMVLLYFF
250 260 270 280 290 300
YKWLVYVMIA IFCIASAMSL YNCLAALIHK IPYGQCTIAC RGKNMEVRLI FLSGLCIAVA
310 320 330 340 350 360
VVWAVFRNED RWAWILQDIL GIAFCLNLIK TLKLPNFKSC VILLGLLLLY DVFFVFITPF
370 380 390 400 410 420
ITKNGESIMV ELAAGPFGNN EKLPVVIRVP KLIYFSVMSV CLMPVSILGF GDIIVPGLLI
430 440 450 460 470 480
AYCRRFDVQT GSSYIYYVSS TVAYAIGMIL TFVVLVLMKK GQPALLYLVP CTLITASVVA
490 500 510 520
WRRKEMKKFW KGNSYQMMDH LDCATNEENP VISGEQIVQQ
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 0 Cleavages - 5 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q8TCT8-26-unknown | QEAILH... | 26 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q8TCT8-43-unknown | MLYNPY... | 43 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000453932 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...GYWSGL | 191 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000453932 | |||
| ...QIVQQ | 520 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| TNFA_HUMAN | 34 | FLSL.|.LFSF | inferred from experiment | unknown | MEROPS | Haass C | Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) | 19189970, |
| TNFA_HUMAN | 36 | SLFS.|.SFLI | inferred from experiment | unknown | MEROPS | Haass C | Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) | 19189970, |
| TNFA_HUMAN | 39 | SFLI.|.IVAG | inferred from experiment | unknown | MEROPS | Haass C | Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) | 19189970, |
| TNFA_HUMAN | 49 | LFCL.|.LLHF | inferred from experiment | unknown | MEROPS | Haass C | Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) | 19189970, |
| TNFA_HUMAN | 51 | CLLH.|.HFGV | inferred from experiment | unknown | MEROPS | Haass C | Fluhrer R et al.:Intramembrane proteolysis by si... (A22.007) | 19189970, |