TopFIND 4.0

O14672: Disintegrin and metalloproteinase domain-containing protein 10

General Information

Protein names
- Disintegrin and metalloproteinase domain-containing protein 10
- ADAM 10
- 3.4.24.81 {ECO:0000269|PubMed:11477090, ECO:0000269|PubMed:12475894, ECO:0000269|PubMed:16239146, ECO:0000269|PubMed:17557115, ECO:0000269|PubMed:19114711, ECO:0000269|PubMed:20592283, ECO:0000269|PubMed:29224781}
- CDw156
- Kuzbanian protein homolog
- Mammalian disintegrin-metalloprotease
- CD156c
Gene names ADAM10
Organism Homo sapiens
Protease Family M12.210
Protease ID M12.210
Chromosome location
UniProt ID O14672

6

N-termini

4

C-termini

7

Cleavages

38

Substrates

Sequence

        10         20         30         40         50         60 
MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL 
        70         80         90        100        110        120 
RLDFHAHGRH FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI 
       130        140        150        160        170        180 
DGRFEGFIQT RGGTFYVEPA ERYIKDRTLP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE 
       190        200        210        220        230        240 
RMRKYQMTGV EEVTQIPQEE HAANGPELLR KKRTTSAEKN TCQLYIQTDH LFFKYYGTRE 
       250        260        270        280        290        300 
AVIAQISSHV KAIDTIYQTT DFSGIRNISF MVKRIRINTT ADEKDPTNPF RFPNIGVEKF 
       310        320        330        340        350        360 
LELNSEQNHD DYCLAYVFTD RDFDDGVLGL AWVGAPSGSS GGICEKSKLY SDGKKKSLNT 
       370        380        390        400        410        420 
GIITVQNYGS HVPPKVSHIT FAHEVGHNFG SPHDSGTECT PGESKNLGQK ENGNYIMYAR 
       430        440        450        460        470        480 
ATSGDKLNNN KFSLCSIRNI SQVLEKKRNN CFVESGQPIC GNGMVEQGEE CDCGYSDQCK 
       490        500        510        520        530        540 
DECCFDANQP EGRKCKLKPG KQCSPSQGPC CTAQCAFKSK SEKCRDDSDC AREGICNGFT 
       550        560        570        580        590        600 
ALCPASDPKP NFTDCNRHTQ VCINGQCAGS ICEKYGLEEC TCASSDGKDD KELCHVCCMK 
       610        620        630        640        650        660 
KMDPSTCAST GSVQWSRHFS GRTITLQPGS PCNDFRGYCD VFMRCRLVDA DGPLARLKKA 
       670        680        690        700        710        720 
IFSPELYENI AEWIVAHWWA VLLMGIALIM LMAGFIKICS VHTPSSNPKL PPPKPLPGTL 
       730        740    
KRRRPPQPIQ QPQRQRPRES YQMGHMRR

Isoforms

- Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 10

Sequence View

        10         20         30         40         50         60 
MVLLRVLILL LSWAAGMGGQ YGNPLNKYIR HYEGLSYNVD SLHQKHQRAK RAVSHEDQFL 
        70         80         90        100        110        120 
RLDFHAHGRH FNLRMKRDTS LFSDEFKVET SNKVLDYDTS HIYTGHIYGE EGSFSHGSVI 
       130        140        150        160        170        180 
DGRFEGFIQT RGGTFYVEPA ERYIKDRTLP FHSVIYHEDD INYPHKYGPQ GGCADHSVFE 
       190        200        210        220        230        240 
RMRKYQMTGV EEVTQIPQEE HAANGPELLR KKRTTSAEKN TCQLYIQTDH LFFKYYGTRE 
       250        260        270        280        290        300 
AVIAQISSHV KAIDTIYQTT DFSGIRNISF MVKRIRINTT ADEKDPTNPF RFPNIGVEKF 
       310        320        330        340        350        360 
LELNSEQNHD DYCLAYVFTD RDFDDGVLGL AWVGAPSGSS GGICEKSKLY SDGKKKSLNT 
       370        380        390        400        410        420 
GIITVQNYGS HVPPKVSHIT FAHEVGHNFG SPHDSGTECT PGESKNLGQK ENGNYIMYAR 
       430        440        450        460        470        480 
ATSGDKLNNN KFSLCSIRNI SQVLEKKRNN CFVESGQPIC GNGMVEQGEE CDCGYSDQCK 
       490        500        510        520        530        540 
DECCFDANQP EGRKCKLKPG KQCSPSQGPC CTAQCAFKSK SEKCRDDSDC AREGICNGFT 
       550        560        570        580        590        600 
ALCPASDPKP NFTDCNRHTQ VCINGQCAGS ICEKYGLEEC TCASSDGKDD KELCHVCCMK 
       610        620        630        640        650        660 
KMDPSTCAST GSVQWSRHFS GRTITLQPGS PCNDFRGYCD VFMRCRLVDA DGPLARLKKA 
       670        680        690        700        710        720 
IFSPELYENI AEWIVAHWWA VLLMGIALIM LMAGFIKICS VHTPSSNPKL PPPKPLPGTL 
       730        740    
KRRRPPQPIQ QPQRQRPRES YQMGHMRR



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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 7 Cleavages - 38 Substrates

N-termini

C-termini

Cleavages

Substrates