P04156: Major prion protein

General Information

Protein names	- Major prion protein - PrP - ASCR - PrP27-30 - PrP33-35C - CD230
Gene names	PRNP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P04156

4 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP
        70         80         90        100        110        120
HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN KPSKPKTNMK HMAGAAAAGA
       130        140        150        160        170        180
VVGGLGGYML GSAMSRPIIH FGSDYEDRYY RENMHRYPNQ VYYRPMDEYS NQNNFVHDCV
       190        200        210        220        230        240
NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCITQYER ESQAYYQRGS SMVLFSSPPV
       250
ILLISFLIFL IVG

Isoforms

- Isoform 2 of Major prion protein

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P04156-8-unknown	MLVLFV...	8	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86201
P04156-23-unknown	KKRPKP...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P04156-23-unknown	KKRPKP...	23	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113391
P04156-25-unknown	RPKPGG...	25	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18429
P04156-25-unknown	RPKPGG...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136754
P04156-112-unknown	MAGAAA...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC73
P04156-112-unknown	MAGAAA...	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC118
P04156-112-unknown	MAGAAA...	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142642

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GLCKKR	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18429
...TNMKHM	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC73
...TNMKHM	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC118
...TNMKHM	111	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125840
...YQRGSS	230	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YQRGSS	230	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92051
...FLIVG	253	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81819

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	24	CKKR.\|.RPKP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
ADA10_HUMAN	111	MKHM.\|.MAGA	inferred from experiment	unknown	MEROPS	Haik S	Laffont-Proust I et al.:The N-terminal cleavage of cell... (M12.210)	16263114,
ADA17_HUMAN	111	MKHM.\|.MAGA	inferred from experiment	unknown	MEROPS	Checler F	Alfa Cisse M et al.:M1 and M3 muscarinic receptors ... (M12.217)	17428986,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)