P01135: Protransforming growth factor alpha
Protein names | - Protransforming growth factor alpha - Transforming growth factor alpha - TGF-alpha - EGF-like TGF - ETGF - TGF type 1 |
---|---|
Gene names | TGFA |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P01135 |
13
N-termini
12
C-termini
12
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC
70 80 90 100 110 120
RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL
130 140 150 160
IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV
Isoforms
- Isoform 2 of Protransforming growth factor alpha - Isoform 3 of Protransforming growth factor alpha - Isoform 4 of Protransforming growth factor alpha - Isoform 5 of Protransforming growth factor alphaSequence View
10 20 30 40 50 60
MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC
70 80 90 100 110 120
RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL
130 140 150 160
IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV
10 20 30 40 50 60
MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC
70 80 90 100 110 120
RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL
130 140 150 160
IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV
10 20 30 40 50 60
MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC
70 80 90 100 110 120
RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL
130 140 150 160
IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV
10 20 30 40 50 60
MVPSAGQLAL FALGIVLAAC QALENSTSPL SADPPVAAAV VSHFNDCPDS HTQFCFHGTC
70 80 90 100 110 120
RFLVQEDKPA CVCHSGYVGA RCEHADLLAV VAASQKKQAI TALVVVSIVA LAVLIITCVL
130 140 150 160
IHCCQVRKHC EWCRALICRH EKPSALLKGR TACCHSETVV
Protein Neighborhood
Domains & Features
13 N-termini - 12 C-termini - 12 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P01135-1-unknown | MVPSAG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt92020 | |||
P01135-1-unknown | MVPSAG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt92021 | |||
P01135-1-unknown | MVPSAG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt92022 | |||
P01135-1-unknown | MVPSAG... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt92023 | |||
P01135-24-unknown | ENSTSP... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P01135-24-unknown | ENSTSP... | 24 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt113507 | |||
P01135-40-unknown | VVSHFN... | 40 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P01135-40-unknown | VVSHFN... | 40 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC70 | |||
P01135-40-unknown | VVSHFN... | 40 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC110 | |||
P01135-40-unknown | VVSHFN... | 40 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115394 | |||
P01135-40-unknown | VVSHFN... | 40 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115396 | |||
P01135-40-unknown | VVSHFN... | 40 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115397 | |||
P01135-40-unknown | VVSHFN... | 40 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115395 | |||
P01135-51-unknown | HTQFCF... | 51 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15555 | |||
P01135-51-unknown | HTQFCF... | 51 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139204 | |||
P01135-51-unknown | HTQFCF... | 51 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139207 | |||
P01135-51-unknown | HTQFCF... | 51 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139208 | |||
P01135-51-unknown | HTQFCF... | 51 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139285 | |||
P01135-54-unknown | FCFHGT... | 54 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15560 | |||
P01135-54-unknown | FCFHGT... | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139423 | |||
P01135-54-unknown | FCFHGT... | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139426 | |||
P01135-54-unknown | FCFHGT... | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139427 | |||
P01135-54-unknown | FCFHGT... | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139477 | |||
P01135-55-unknown | CFHGTC... | 55 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15565 | |||
P01135-55-unknown | CFHGTC... | 55 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139479 | |||
P01135-55-unknown | CFHGTC... | 55 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139481 | |||
P01135-55-unknown | CFHGTC... | 55 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139482 | |||
P01135-55-unknown | CFHGTC... | 55 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139557 | |||
P01135-57-unknown | HGTCRF... | 57 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15570 | |||
P01135-57-unknown | HGTCRF... | 57 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139620 | |||
P01135-57-unknown | HGTCRF... | 57 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139622 | |||
P01135-57-unknown | HGTCRF... | 57 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139623 | |||
P01135-57-unknown | HGTCRF... | 57 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139702 | |||
P01135-60-unknown | CRFLVQ... | 60 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15575 | |||
P01135-60-unknown | CRFLVQ... | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139850 | |||
P01135-60-unknown | CRFLVQ... | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139852 | |||
P01135-60-unknown | CRFLVQ... | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139854 | |||
P01135-60-unknown | CRFLVQ... | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139948 | |||
P01135-61-unknown | RFLVQE... | 61 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15580 | |||
P01135-61-unknown | RFLVQE... | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139949 | |||
P01135-61-unknown | RFLVQE... | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139950 | |||
P01135-61-unknown | RFLVQE... | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt139952 | |||
P01135-61-unknown | RFLVQE... | 61 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140035 | |||
P01135-74-unknown | HSGYVG... | 74 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15585 | |||
P01135-74-unknown | HSGYVG... | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140855 | |||
P01135-74-unknown | HSGYVG... | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140856 | |||
P01135-74-unknown | HSGYVG... | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140857 | |||
P01135-74-unknown | HSGYVG... | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140929 | |||
P01135-75-unknown | SGYVGA... | 75 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15590 | |||
P01135-75-unknown | SGYVGA... | 75 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140934 | |||
P01135-75-unknown | SGYVGA... | 75 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140937 | |||
P01135-75-unknown | SGYVGA... | 75 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140939 | |||
P01135-75-unknown | SGYVGA... | 75 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt140996 | |||
P01135-80-unknown | ARCEHA... | 80 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15595 | |||
P01135-80-unknown | ARCEHA... | 80 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141272 | |||
P01135-80-unknown | ARCEHA... | 80 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141273 | |||
P01135-80-unknown | ARCEHA... | 80 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141274 | |||
P01135-80-unknown | ARCEHA... | 80 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141320 | |||
P01135-90-unknown | VVAASQ... | 90 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC112 | |||
P01135-90-unknown | VVAASQ... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141766 | |||
P01135-90-unknown | VVAASQ... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141767 | |||
P01135-90-unknown | VVAASQ... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141768 | |||
P01135-90-unknown | VVAASQ... | 90 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt141821 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...PVAAAV | 39 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC70 | |||
...PVAAAV | 39 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC110 | |||
...PVAAAV | 39 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt121352 | |||
...DCPDSH | 50 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15555 | |||
...DCPDSH | 50 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122360 | |||
...DSHTQF | 53 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15560 | |||
...DSHTQF | 53 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122508 | |||
...DSHTQF | 53 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122511 | |||
...DSHTQF | 53 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122512 | |||
...DSHTQF | 53 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122567 | |||
...SHTQFC | 54 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15565 | |||
...SHTQFC | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122569 | |||
...SHTQFC | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122571 | |||
...SHTQFC | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122572 | |||
...SHTQFC | 54 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122649 | |||
...TQFCFH | 56 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15570 | |||
...TQFCFH | 56 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122715 | |||
...TQFCFH | 56 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122717 | |||
...TQFCFH | 56 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122718 | |||
...TQFCFH | 56 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122801 | |||
...CFHGTC | 59 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15575 | |||
...CFHGTC | 59 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122949 | |||
...CFHGTC | 59 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122952 | |||
...CFHGTC | 59 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt122954 | |||
...CFHGTC | 59 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123053 | |||
...FHGTCR | 60 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15580 | |||
...FHGTCR | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123054 | |||
...FHGTCR | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123055 | |||
...FHGTCR | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123057 | |||
...FHGTCR | 60 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123141 | |||
...PACVCH | 73 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15585 | |||
...PACVCH | 73 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123995 | |||
...PACVCH | 73 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123996 | |||
...PACVCH | 73 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt123997 | |||
...PACVCH | 73 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124073 | |||
...ACVCHS | 74 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15590 | |||
...ACVCHS | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124078 | |||
...ACVCHS | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124081 | |||
...ACVCHS | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124083 | |||
...ACVCHS | 74 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124146 | |||
...SGYVGA | 79 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15595 | |||
...SGYVGA | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124435 | |||
...SGYVGA | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124436 | |||
...SGYVGA | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124437 | |||
...SGYVGA | 79 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt124485 | |||
...ADLLAV | 89 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...ADLLAV | 89 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC112 | |||
...ADLLAV | 89 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91460 | |||
...ADLLAV | 89 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91462 | |||
...ADLLAV | 89 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91463 | |||
...ADLLAV | 89 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt91461 | |||
...SETVV | 160 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...SETVV | 160 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt87638 |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|