P12830: Cadherin-1

General Information

Protein names	- Cadherin-1 - CAM 120/80 - Epithelial cadherin - E-cadherin - Uvomorulin - CD324 - E-Cad/CTF1 - E-Cad/CTF2 - E-Cad/CTF3
Gene names	CDH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12830

7 N-termini

7 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGPWSRSLSA LLLLLQVSSW LCQEPEPCHP GFDAESYTFT VPRRHLERGR VLGRVNFEDC
        70         80         90        100        110        120
TGRQRTAYFS LDTRFKVGTD GVITVKRPLR FHNPQIHFLV YAWDSTYRKF STKVTLNTVG
       130        140        150        160        170        180
HHHRPPPHQA SVSGIQAELL TFPNSSPGLR RQKRDWVIPP ISCPENEKGP FPKNLVQIKS
       190        200        210        220        230        240
NKDKEGKVFY SITGQGADTP PVGVFIIERE TGWLKVTEPL DRERIATYTL FSHAVSSNGN
       250        260        270        280        290        300
AVEDPMEILI TVTDQNDNKP EFTQEVFKGS VMEGALPGTS VMEVTATDAD DDVNTYNAAI
       310        320        330        340        350        360
AYTILSQDPE LPDKNMFTIN RNTGVISVVT TGLDRESFPT YTLVVQAADL QGEGLSTTAT
       370        380        390        400        410        420
AVITVTDTND NPPIFNPTTY KGQVPENEAN VVITTLKVTD ADAPNTPAWE AVYTILNDDG
       430        440        450        460        470        480
GQFVVTTNPV NNDGILKTAK GLDFEAKQQY ILHVAVTNVV PFEVSLTTST ATVTVDVLDV
       490        500        510        520        530        540
NEAPIFVPPE KRVEVSEDFG VGQEITSYTA QEPDTFMEQK ITYRIWRDTA NWLEINPDTG
       550        560        570        580        590        600
AISTRAELDR EDFEHVKNST YTALIIATDN GSPVATGTGT LLLILSDVND NAPIPEPRTI
       610        620        630        640        650        660
FFCERNPKPQ VINIIDADLP PNTSPFTAEL THGASANWTI QYNDPTQESI ILKPKMALEV
       670        680        690        700        710        720
GDYKINLKLM DNQNKDQVTT LEVSVCDCEG AAGVCRKAQP VEAGLQIPAI LGILGGILAL
       730        740        750        760        770        780
LILILLLLLF LRRRAVVKEP LLPPEDDTRD NVYYYDEEGG GEEDQDFDLS QLHRGLDARP
       790        800        810        820        830        840
EVTRNDVAPT LMSVPRYLPR PANPDEIGNF IDENLKAADT DPTAPPYDSL LVFDYEGSGS
       850        860        870        880
EAASLSSLNS SESDKDQDYD YLNEWGNRFK KLADMYGGGE DD

Isoforms

- Isoform 2 of Cadherin-1

Sequence View

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P12830-23-unknown	QEPEPC...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12830-155-unknown	DWVIPP...	155	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12830-155-unknown	DWVIPP...	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16303
P12830-586-unknown	SDVNDN...	586	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21526
P12830-587-unknown	DVNDNA...	587	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21527
P12830-701-unknown	VEAGLQ...	701	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12830-701-unknown	VEAGLQ...	701	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC24031
P12830-732-unknown	RRRAVV...	732	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12830-732-unknown	RRRAVV...	732	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31545
P12830-751-unknown	NVYYYD...	751	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RRQKRD	154	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16303
...LLLILS	585	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21526
...LLILSD	586	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21527
...RKAQPV	700	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC24031
...LLLFLR	731	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31545
...GGEDD	882	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GGEDD	882		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...GGEDD	882		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	154	QKRD.\|.DWVI	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
MMP14_HUMAN	585	LILS.\|.SDVN	inferred from experiment	unknown	MEROPS		Merops MMP14_HUMAN -> CADH1_HUMAN @585
MMP14_HUMAN	586	ILSD.\|.DVND	inferred from experiment	unknown	MEROPS		Merops MMP14_HUMAN -> CADH1_HUMAN @586
MMP7_HUMAN	700	AQPV.\|.VEAG	inferred from experiment	unknown	MEROPS		Merops MMP7_HUMAN -> CADH1_HUMAN @700
PSN1_HUMAN	731	LFLR.\|.RRRA	inferred from experiment	unknown	MEROPS	Wolfe MS	Xia W et al.:Intramembrane proteolysis by pr... (A22.001)	12808018,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)