O00292: Left-right determination factor 2

General Information

Protein names	- Left-right determination factor 2 - Endometrial bleeding-associated factor - Left-right determination factor A - Protein lefty-2 - Protein lefty-A - Transforming growth factor beta-4 - TGF-beta-4
Gene names	LEFTY2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00292

4 N-termini

2 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK LVIPAHVRAQ
        70         80         90        100        110        120
YVVLLRRSHG DRSRGKRFSQ SFREVAGRFL ASEASTHLLV FGMEQRLPPN SELVQAVLRL
       130        140        150        160        170        180
FQEPVPKAAL HRHGRLSPRS AQARVTVEWL RVRDDGSNRT SLIDSRLVSV HESGWKAFDV
       190        200        210        220        230        240
TEAVNFWQQL SRPRQPLLLQ VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL
       250        260        270        280        290        300
DLRDYGAQGD CDPEAPMTEG TRCCRQEMYI DLQGMKWAKN WVLEPPGFLA YECVGTCQQP
       310        320        330        340        350        360
PEALAFNWPF LGPRQCIASE TASLPMIVSI KEGGRTRPQV VSLPNMRVQK CSCASDGALV

PRRLQP

Isoforms

- Isoform 2 of Left-right determination factor 2

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O00292-1-unknown	MWPLWL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt79535
O00292-22-unknown	LTEEQL...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00292-22-unknown	LTEEQL...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113112
O00292-77-unknown	RFSQSF...	77	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O00292-78-unknown	FSQSFR...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26938
O00292-78-unknown	FSQSFR...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27237
O00292-78-unknown	FSQSFR...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26531
O00292-78-unknown	FSQSFR...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26797
O00292-78-unknown	FSQSFR...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9655
O00292-78-unknown	FSQSFR...	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27089

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRGKRF	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26938
...SRGKRF	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27237
...SRGKRF	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26531
...SRGKRF	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26797
...SRGKRF	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9655
...SRGKRF	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27089
...SRGKRF	77	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124330
...RRLQP	366	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RRLQP	366	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75153

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	77	GKRF.\|.FSQS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	77	GKRF.\|.FSQS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	77	GKRF.\|.FSQS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	77	GKRF.\|.FSQS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	77	GKRF.\|.FSQS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	77	GKRF.\|.FSQS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)