P20783: Neurotrophin-3

General Information

Protein names	- Neurotrophin-3 - NT-3 - HDNF - Nerve growth factor 2 - NGF-2 - Neurotrophic factor
Gene names	NTF3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P20783

2 N-termini

2 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSILFYVIFL AYLRGIQGNN MDQRSLPEDS LNSLIIKLIQ ADILKNKLSK QMVDVKENYQ
        70         80         90        100        110        120
STLPKAEAPR EPERGGPAKS AFQPVIAMDT ELLRQQRRYN SPRVLLSDST PLEPPPLYLM
       130        140        150        160        170        180
EDYVGSPVVA NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK
       190        200        210        220        230        240
TGNSPVKQYF YETRCKEARP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI
       250
RIDTSCVCAL SRKIGRT

Isoforms

- Isoform 2 of Neurotrophin-3

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P20783-19-unknown	NNMDQR...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20783-19-unknown	NNMDQR...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112205
P20783-139-unknown	YAEHKS...	139	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P20783-139-unknown	YAEHKS...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9743
P20783-139-unknown	YAEHKS...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27164
P20783-139-unknown	YAEHKS...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27017
P20783-139-unknown	YAEHKS...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27316
P20783-139-unknown	YAEHKS...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16326
P20783-139-unknown	YAEHKS...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26603
P20783-139-unknown	YAEHKS...	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26872
P20783-139-unknown	YAEHKS...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115938

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRRKRY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9743
...SRRKRY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27164
...SRRKRY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27017
...SRRKRY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27316
...SRRKRY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16326
...SRRKRY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26603
...SRRKRY	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26872
...SRRKRY	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128078
...KIGRT	257	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KIGRT	257	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79040

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	138	RKRY.\|.YAEH	inferred from experiment	unknown	MEROPS	Murphy RA	Seidah NG et al.:Cellular processing of the neur... (S08.071)	8603699,
PCSK6_HUMAN	138	RKRY.\|.YAEH	inferred from experiment	unknown	MEROPS	Murphy RA	Seidah NG et al.:Cellular processing of the neur... (S08.071)	8603699,
PCSK5_HUMAN	138	RKRY.\|.YAEH	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	138	RKRY.\|.YAEH	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
KLK4_HUMAN	138	RKRY.\|.YAEH	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
NEC2_HUMAN	138	RKRY.\|.YAEH	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	138	RKRY.\|.YAEH	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)