Q8N119: Matrix metalloproteinase-21

General Information

Protein names	- Matrix metalloproteinase-21 - MMP-21 - 3.4.24.-
Gene names	MMP21
Organism	Homo sapiens
Protease Family
Protease ID	M10.026
Chromosome location
UniProt ID	Q8N119

2 N-termini

2 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLAASIFRPT LLLCWLAAPW PTQPESLFHS RDRSDLEPSP LRQAKPIADL HAAQRFLSRY
        70         80         90        100        110        120
GWSGVWAAWG PSPEGPPETP KGAALAEAVR RFQRANALPA SGELDAATLA AMNRPRCGVP
       130        140        150        160        170        180
DMRPPPPSAP PSPPGPPPRA RSRRSPRAPL SLSRRGWQPR GYPDGGAAQA FSKRTLSWRL
       190        200        210        220        230        240
LGEALSSQLS VADQRRIVAL AFRMWSEVTP LDFREDLAAP GAAVDIKLGF GRGRHLGCPR
       250        260        270        280        290        300
AFDGSGQEFA HAWRLGDIHF DDDEHFTPPT SDTGISLLKV AVHEIGHVLG LPHTYRTGSI
       310        320        330        340        350        360
MQPNYIPQEP AFELDWSDRK AIQKLYGSCE GSFDTAFDWI RKERNQYGEV MVRFSTYFFR
       370        380        390        400        410        420
NSWYWLYENR NNRTRYGDPI QILTGWPGIP THNIDAFVHI WTWKRDERYF FQGNQYWRYD
       430        440        450        460        470        480
SDKDQALTED EQGKSYPKLI SEGFPGIPSP LDTAFYDRRQ KLIYFFKESL VFAFDVNRNR
       490        500        510        520        530        540
VLNSYPKRIT EVFPAVIPQN HPFRNIDSAY YSYAYNSIFF FKGNAYWKVV NDKDKQQNSW
       550        560
LPANGLFPKK FISEKWFDVC DVHISTLNM

Isoforms

Sequence View

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Directness:

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q8N119-25-unknown	ESLFHS...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8N119-145-unknown	SPRAPL...	145	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q8N119-145-unknown	SPRAPL...	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26649
Q8N119-145-unknown	SPRAPL...	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26919
Q8N119-145-unknown	SPRAPL...	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27217
Q8N119-145-unknown	SPRAPL...	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9811
Q8N119-145-unknown	SPRAPL...	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27067
Q8N119-145-unknown	SPRAPL...	145	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27364
Q8N119-145-unknown	SPRAPL...	145	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ARSRRS	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26649
...ARSRRS	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26919
...ARSRRS	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27217
...ARSRRS	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9811
...ARSRRS	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27067
...ARSRRS	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27364
...STLNM	569	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_HUMAN	144	SRRS.\|.SPRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	144	SRRS.\|.SPRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	144	SRRS.\|.SPRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	144	SRRS.\|.SPRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	144	SRRS.\|.SPRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	144	SRRS.\|.SPRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)