P01127: Platelet-derived growth factor subunit B

General Information

Protein names	- Platelet-derived growth factor subunit B - PDGF subunit B - PDGF-2 - Platelet-derived growth factor B chain - Platelet-derived growth factor beta polypeptide - Proto-oncogene c-Sis - Becaplermin
Gene names	PDGFB
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01127

1 N-termini

3 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MNRCWALFLS LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHG DPGEEDGAEL
        70         80         90        100        110        120
DLNMTRSHSG GELESLARGR RSLGSLTIAE PAMIAECKTR TEVFEISRRL IDRTNANFLV
       130        140        150        160        170        180
WPPCVEVQRC SGCCNNRNVQ CRPTQVQLRP VQVRKIEIVR KKPIFKKATV TLEDHLACKC
       190        200        210        220        230        240
ETVAAARPVT RSPGGSQEQR AKTPQTRVTI RTVRVRRPPK GKHRKFKHTH DKTALKETLG

A

Isoforms

- Isoform 2 of Platelet-derived growth factor subunit B

Sequence View

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Protein Neighborhood

Domains & Features

1 N-termini - 3 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01127-82-unknown	SLGSLT...	82	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01127-82-unknown	SLGSLT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26958
P01127-82-unknown	SLGSLT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27254
P01127-82-unknown	SLGSLT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26540
P01127-82-unknown	SLGSLT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26813
P01127-82-unknown	SLGSLT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9679
P01127-82-unknown	SLGSLT...	82	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27105
P01127-82-unknown	SLGSLT...	82	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115824

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ARGRRS	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26958
...ARGRRS	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27254
...ARGRRS	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26540
...ARGRRS	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26813
...ARGRRS	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9679
...ARGRRS	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27105
...ARGRRS	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123551
...ARPVTR	190	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ARPVTR	190	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91891
...ETLGA	241	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80352

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	81	GRRS.\|.SLGS	inferred from experiment	unknown	MEROPS	Khatib AM	Siegfried G et al.:Regulation of the stepwise prot... (S08.071)	16007151,
PCSK7_HUMAN	81	GRRS.\|.SLGS	inferred from experiment	unknown	MEROPS	Khatib AM	Siegfried G et al.:Regulation of the stepwise prot... (S08.071)	16007151,
NEC2_HUMAN	81	GRRS.\|.SLGS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	81	GRRS.\|.SLGS	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	81	GRRS.\|.SLGS	inferred from experiment	unknown	MEROPS	Khatib AM	Siegfried G et al.:Regulation of the stepwise prot... (S08.071)	16007151,
PCSK6_HUMAN	81	GRRS.\|.SLGS	inferred from experiment	unknown	MEROPS	Khatib AM	Siegfried G et al.:Regulation of the stepwise prot... (S08.071)	16007151,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)