Q13683: Integrin alpha-7

General Information

Protein names	- Integrin alpha-7 - Integrin alpha-7 heavy chain - Integrin alpha-7 light chain - Integrin alpha-7 70 kDa form
Gene names	ITGA7
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13683

4 N-termini

3 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Alpha-7X1B of Integrin alpha-7 - Isoform Alpha-7X2B of Integrin alpha-7 - Isoform Alpha-7X2DB of Integrin alpha-7 - Isoform Alpha-7X1X2A of Integrin alpha-7 - Isoform 2 of Integrin alpha-7

Sequence View

        10         20         30         40         50         60
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR
        70         80         90        100        110        120
QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE
       130        140        150        160        170        180
NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE
       190        200        210        220        230        240
WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH
       250        260        270        280        290        300
LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD
       310        320        330        340        350        360
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL
       370        380        390        400        410        420
TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS
       430        440        450        460        470        480
PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI
       490        500        510        520        530        540
KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA
       550        560        570        580        590        600
GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ
       610        620        630        640        650        660
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP
       670        680        690        700        710        720
ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL
       730        740        750        760        770        780
FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL
       790        800        810        820        830        840
CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS
       850        860        870        880        890        900
ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL
       910        920        930        940        950        960
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL
       970        980        990       1000       1010       1020
EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW
      1030       1040       1050       1060       1070       1080
GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV
      1090       1100       1110       1120       1130       1140
PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT
      1150       1160       1170       1180
GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A         10         20         30         40         50         60
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR
        70         80         90        100        110        120
QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE
       130        140        150        160        170        180
NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE
       190        200        210        220        230        240
WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH
       250        260        270        280        290        300
LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD
       310        320        330        340        350        360
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL
       370        380        390        400        410        420
TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS
       430        440        450        460        470        480
PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI
       490        500        510        520        530        540
KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA
       550        560        570        580        590        600
GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ
       610        620        630        640        650        660
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP
       670        680        690        700        710        720
ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL
       730        740        750        760        770        780
FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL
       790        800        810        820        830        840
CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS
       850        860        870        880        890        900
ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL
       910        920        930        940        950        960
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL
       970        980        990       1000       1010       1020
EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW
      1030       1040       1050       1060       1070       1080
GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV
      1090       1100       1110       1120       1130       1140
PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT
      1150       1160       1170       1180
GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A         10         20         30         40         50         60
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR
        70         80         90        100        110        120
QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE
       130        140        150        160        170        180
NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE
       190        200        210        220        230        240
WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH
       250        260        270        280        290        300
LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD
       310        320        330        340        350        360
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL
       370        380        390        400        410        420
TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS
       430        440        450        460        470        480
PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI
       490        500        510        520        530        540
KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA
       550        560        570        580        590        600
GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ
       610        620        630        640        650        660
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP
       670        680        690        700        710        720
ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL
       730        740        750        760        770        780
FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL
       790        800        810        820        830        840
CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS
       850        860        870        880        890        900
ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL
       910        920        930        940        950        960
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL
       970        980        990       1000       1010       1020
EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW
      1030       1040       1050       1060       1070       1080
GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV
      1090       1100       1110       1120       1130       1140
PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT
      1150       1160       1170       1180
GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A         10         20         30         40         50         60
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR
        70         80         90        100        110        120
QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE
       130        140        150        160        170        180
NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE
       190        200        210        220        230        240
WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH
       250        260        270        280        290        300
LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD
       310        320        330        340        350        360
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL
       370        380        390        400        410        420
TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS
       430        440        450        460        470        480
PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI
       490        500        510        520        530        540
KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA
       550        560        570        580        590        600
GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ
       610        620        630        640        650        660
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP
       670        680        690        700        710        720
ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL
       730        740        750        760        770        780
FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL
       790        800        810        820        830        840
CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS
       850        860        870        880        890        900
ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL
       910        920        930        940        950        960
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL
       970        980        990       1000       1010       1020
EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW
      1030       1040       1050       1060       1070       1080
GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV
      1090       1100       1110       1120       1130       1140
PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT
      1150       1160       1170       1180
GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A         10         20         30         40         50         60
MAGARSRDPW GASGICYLFG SLLVELLFSR AVAFNLDVMG ALRKEGEPGS LFGFSVALHR
        70         80         90        100        110        120
QLQPRPQSWL LVGAPQALAL PGQQANRTGG LFACPLSLEE TDCYRVDIDQ GADMQKESKE
       130        140        150        160        170        180
NQWLGVSVRS QGPGGKIVTC AHRYEARQRV DQILETRDMI GRCFVLSQDL AIRDELDGGE
       190        200        210        220        230        240
WKFCEGRPQG HEQFGFCQQG TAAAFSPDSH YLLFGAPGTY NWKGTARVEL CAQGSADLAH
       250        260        270        280        290        300
LDDGPYEAGG EKEQDPRLIP VPANSYFGLL FVTNIDSSDP DQLVYKTLDP ADRLPGPAGD
       310        320        330        340        350        360
LALNSYLGFS IDSGKGLVRA EELSFVAGAP RANHKGAVVI LRKDSASRLV PEVMLSGERL
       370        380        390        400        410        420
TSGFGYSLAV ADLNSDGWPD LIVGAPYFFE RQEELGGAVY VYLNQGGHWA GISPLRLCGS
       430        440        450        460        470        480
PDSMFGISLA VLGDLNQDGF PDIAVGAPFD GDGKVFIYHG SSLGVVAKPS QVLEGEAVGI
       490        500        510        520        530        540
KSFGYSLSGS LDMDGNQYPD LLVGSLADTA VLFRARPILH VSHEVSIAPR SIDLEQPNCA
       550        560        570        580        590        600
GGHSVCVDLR VCFSYIAVPS SYSPTVALDY VLDADTDRRL RGQVPRVTFL SRNLEEPKHQ
       610        620        630        640        650        660
ASGTVWLKHQ HDRVCGDAMF QLQENVKDKL RAIVVTLSYS LQTPRLRRQA PGQGLPPVAP
       670        680        690        700        710        720
ILNAHQPSTQ RAEIHFLKQG CGEDKICQSN LQLVRARFCT RVSDTEFQPL PMDVDGTTAL
       730        740        750        760        770        780
FALSGQPVIG LELMVTNLPS DPAQPQADGD DAHEAQLLVM LPDSLHYSGV RALDPAEKPL
       790        800        810        820        830        840
CLSNENASHV ECELGNPMKR GAQVTFYLIL STSGISIETT ELEVELLLAT ISEQELHPVS
       850        860        870        880        890        900
ARARVFIELP LSIAGMAIPQ QLFFSGVVRG ERAMQSERDV GSKVKYEVTV SNQGQSLRTL
       910        920        930        940        950        960
GSAFLNIMWP HEIANGKWLL YPMQVELEGG QGPGQKGLCS PRPNILHLDV DSRDRRRREL
       970        980        990       1000       1010       1020
EPPEQQEPGE RQEPSMSWWP VSSAEKKKNI TLDCARGTAN CVVFSCPLYS FDRAAVLHVW
      1030       1040       1050       1060       1070       1080
GRLWNSTFLE EYSAVKSLEV IVRANITVKS SIKNLMLRDA STVIPVMVYL DPMAVVAEGV
      1090       1100       1110       1120       1130       1140
PWWVILLAVL AGLLVLALLV LLLWKMGFFK RAKHPEATVP QYHAVKIPRE DRQQFKEEKT
      1150       1160       1170       1180
GTILRNNWGS PRREGPDAHP ILAADGHPEL GPDGHPGPGT A

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q13683-1-unknown	MAGARS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78137
Q13683-1-unknown	MAGARS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78138
Q13683-1-unknown	MAGARS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt78139
Q13683-34-unknown	FNLDVM...	34	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13683-34-unknown	FNLDVM...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115129
Q13683-34-unknown	FNLDVM...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115130
Q13683-34-unknown	FNLDVM...	34	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115131
Q13683-648-unknown	RQAPGQ...	648	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13683-648-unknown	RQAPGQ...	648	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116269
Q13683-648-unknown	RQAPGQ...	648	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116270
Q13683-648-unknown	RQAPGQ...	648	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116268
Q13683-959-unknown	ELEPPE...	959	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q13683-959-unknown	ELEPPE...	959	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26638
Q13683-959-unknown	ELEPPE...	959	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26908
Q13683-959-unknown	ELEPPE...	959	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27206
Q13683-959-unknown	ELEPPE...	959	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9799
Q13683-959-unknown	ELEPPE...	959	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27056
Q13683-959-unknown	ELEPPE...	959	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27353
Q13683-959-unknown	ELEPPE...	959	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116424
Q13683-959-unknown	ELEPPE...	959	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116425
Q13683-959-unknown	ELEPPE...	959	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116426

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DSRDRR	955	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DSRDRR	955	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93545
...DSRDRR	955	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93546
...DSRDRR	955	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93547
...DRRRRE	958	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26638
...DRRRRE	958	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26908
...DRRRRE	958	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27206
...DRRRRE	958	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9799
...DRRRRE	958	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27056
...DRRRRE	958	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27353
...DRRRRE	958	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140294
...DRRRRE	958	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140441
...DRRRRE	958	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140455
...GPGTA	1181	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GPGTA	1181	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73757
...GPGTA	1181	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73756
...GPGTA	1181	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73755

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_HUMAN	958	RRRE.\|.ELEP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	958	RRRE.\|.ELEP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	958	RRRE.\|.ELEP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	958	RRRE.\|.ELEP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	958	RRRE.\|.ELEP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	958	RRRE.\|.ELEP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)