P01344: Insulin-like growth factor II

General Information

Protein names	- Insulin-like growth factor II - IGF-II - Somatomedin-A - T3M-11-derived growth factor - Insulin-like growth factor II - Insulin-like growth factor II Ala-25 Del - Preptin
Gene names	IGF2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01344

16 N-termini

14 C-termini

17 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Insulin-like growth factor II - Isoform 3 of Insulin-like growth factor II

Sequence View

        10         20         30         40         50         60
MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS
        70         80         90        100        110        120
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK
       130        140        150        160        170        180
QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK

        10         20         30         40         50         60
MGIPMGKSML VLLTFLAFAS CCIAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPASRVS
        70         80         90        100        110        120
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTPPTV LPDNFPRYPV GKFFQYDTWK
       130        140        150        160        170        180
QSTQRLRRGL PALLRARRGH VLAKELEAFR EAKRHRPLIA LPTQDPAHGG APPEMASNRK

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Evidence Codes:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

16 N-termini - 14 C-termini - 17 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P01344-1-unknown	MGIPMG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77635
P01344-1-unknown	MGIPMG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99619
P01344-25-unknown	AYRPSE...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01344-25-unknown	AYRPSE...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113722
P01344-25-unknown	AYRPSE...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113721
P01344-26-unknown	YRPSET...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01344-26-unknown	YRPSET...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113945
P01344-26-unknown	YRPSET...	26	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113944
P01344-41-unknown	LQFVCG...	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15614
P01344-41-unknown	LQFVCG...	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142265
P01344-43-unknown	FVCGDR...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15617
P01344-43-unknown	FVCGDR...	43	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142312
P01344-51-unknown	YFSRPA...	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15620
P01344-51-unknown	YFSRPA...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142724
P01344-52-unknown	FSRPAS...	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15622
P01344-52-unknown	FSRPAS...	52	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142792
P01344-53-unknown	SRPASR...	53	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15624
P01344-53-unknown	SRPASR...	53	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142860
P01344-61-unknown	RRSRGI...	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15626
P01344-61-unknown	RRSRGI...	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143302
P01344-61-unknown	RRSRGI...	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196342
P01344-62-unknown	RSRGIV...	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15628
P01344-62-unknown	RSRGIV...	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143343
P01344-62-unknown	RSRGIV...	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196349
P01344-72-unknown	FRSCDL...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15630
P01344-72-unknown	FRSCDL...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140945
P01344-72-unknown	FRSCDL...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143796
P01344-73-unknown	RSCDLA...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15633
P01344-73-unknown	RSCDLA...	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141007
P01344-73-unknown	RSCDLA...	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143833
P01344-88-unknown	AKSERD...	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15636
P01344-88-unknown	AKSERD...	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141856
P01344-88-unknown	AKSERD...	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144476
P01344-89-unknown	KSERDV...	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15639
P01344-89-unknown	KSERDV...	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141919
P01344-89-unknown	KSERDV...	89	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144516
P01344-93-unknown	DVSTPP...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26969
P01344-93-unknown	DVSTPP...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27265
P01344-93-unknown	DVSTPP...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26559
P01344-93-unknown	DVSTPP...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26824
P01344-93-unknown	DVSTPP...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9695
P01344-93-unknown	DVSTPP...	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27116
P01344-93-unknown	DVSTPP...	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142170
P01344-93-unknown	DVSTPP...	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144683
P01344-139-unknown	GHVLAK...	139		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01344-139-unknown	GHVLAK...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180495
P01344-139-unknown	GHVLAK...	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt180494

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELVDTL	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15614
...ELVDTL	40	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121414
...ELVDTL	40	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125454
...VDTLQF	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15617
...VDTLQF	42	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121594
...VDTLQF	42	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125503
...GDRGFY	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15620
...GDRGFY	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125925
...GDRGFY	50	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153894
...DRGFYF	51	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15622
...DRGFYF	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125997
...DRGFYF	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153898
...RGFYFS	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15624
...RGFYFS	52	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126069
...RGFYFS	52	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153908
...ASRVSR	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15626
...ASRVSR	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126532
...SRVSRR	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15628
...SRVSRR	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126574
...VEECCF	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15630
...VEECCF	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127038
...EECCFR	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15633
...EECCFR	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127077
...YCATPA	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15636
...YCATPA	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125035
...YCATPA	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127741
...CATPAK	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15639
...CATPAK	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125099
...CATPAK	88	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127781
...PAKSER	91	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PAKSER	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91475
...PAKSER	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91474
...AKSERD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26969
...AKSERD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27265
...AKSERD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26559
...AKSERD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26824
...AKSERD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9695
...AKSERD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27116
...AKSERD	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125357
...AKSERD	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127951
...ASNRK	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73253
...ASNRK	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt73254

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
IDE_HUMAN	40	VDTL.\|.LQFV	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	42	TLQF.\|.FVCG	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	50	RGFY.\|.YFSR	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	51	GFYF.\|.FSRP	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	52	FYFS.\|.SRPA	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	60	RVSR.\|.RRSR	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	61	VSRR.\|.RSRG	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	71	ECCF.\|.FRSC	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	72	CCFR.\|.RSCD	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	87	ATPA.\|.AKSE	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
IDE_HUMAN	88	TPAK.\|.KSER	inferred from experiment	unknown	MEROPS	Tang WJ	Guo Q et al.:Molecular basis for the recogni... (M16.002)	19896952,
PCSK5_HUMAN	92	SERD.\|.DVST	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	92	SERD.\|.DVST	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	92	SERD.\|.DVST	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	92	SERD.\|.DVST	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	92	SERD.\|.DVST	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	92	SERD.\|.DVST	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)