P12644: Bone morphogenetic protein 4

General Information

Protein names	- Bone morphogenetic protein 4 - BMP-4 - Bone morphogenetic protein 2B - BMP-2B
Gene names	BMP4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12644

4 N-termini

4 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MIPGNRMLMV VLLCQVLLGG ASHASLIPET GKKKVAEIQG HAGGRRSGQS HELLRDFEAT
        70         80         90        100        110        120
LLQMFGLRRR PQPSKSAVIP DYMRDLYRLQ SGEEEEEQIH STGLEYPERP ASRANTVRSF
       130        140        150        160        170        180
HHEEHLENIP GTSENSAFRF LFNLSSIPEN EVISSAELRL FREQVDQGPD WERGFHRINI
       190        200        210        220        230        240
YEVMKPPAEV VPGHLITRLL DTRLVHHNVT RWETFDVSPA VLRWTREKQP NYGLAIEVTH
       250        260        270        280        290        300
LHQTRTHQGQ HVRISRSLPQ GSGNWAQLRP LLVTFGHDGR GHALTRRRRA KRSPKHHSQR
       310        320        330        340        350        360
ARKKNKNCRR HSLYVDFSDV GWNDWIVAPP GYQAFYCHGD CPFPLADHLN STNHAIVQTL
       370        380        390        400
VNSVNSSIPK ACCVPTELSA ISMLYLDEYD KVVLKNYQEM VVEGCGCR

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P12644-20-unknown	GASHAS...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12644-26-unknown	LIPETG...	26	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453691
P12644-64-unknown	MFGLRR...	64	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453365
P12644-293-unknown	SPKHHS...	293	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12644-293-unknown	SPKHHS...	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9734
P12644-293-unknown	SPKHHS...	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27153
P12644-293-unknown	SPKHHS...	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27006
P12644-293-unknown	SPKHHS...	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27305
P12644-293-unknown	SPKHHS...	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26594
P12644-293-unknown	SPKHHS...	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26861

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...YPERPA	110	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453467
...RRAKRS	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9734
...RRAKRS	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27153
...RRAKRS	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27006
...RRAKRS	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27305
...RRAKRS	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26594
...RRAKRS	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26861
...PGYQAF	334	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000453365
...GCGCR	408	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	292	AKRS.\|.SPKH	inferred from experiment	unknown	MEROPS	Christian JL	Cui Y et al.:BMP-4 is proteolytically activa... (S08.071)	9707432,
PCSK6_HUMAN	292	AKRS.\|.SPKH	inferred from experiment	unknown	MEROPS	Christian JL	Cui Y et al.:BMP-4 is proteolytically activa... (S08.075)	9707432,
PCSK5_HUMAN	292	AKRS.\|.SPKH	inferred from experiment	unknown	MEROPS	Christian JL	Cui Y et al.:BMP-4 is proteolytically activa... (S08.071)	9707432,
PCSK7_HUMAN	292	AKRS.\|.SPKH	inferred from experiment	unknown	MEROPS	Christian JL	Cui Y et al.:BMP-4 is proteolytically activa... (S08.075)	9707432,
NEC2_HUMAN	292	AKRS.\|.SPKH	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	292	AKRS.\|.SPKH	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)