Q14563: Semaphorin-3A

General Information

Protein names	- Semaphorin-3A - Semaphorin III - Sema III
Gene names	SEMA3A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q14563

2 N-termini

4 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGWLTRIVCL FWGVLLTARA NYQNGKNNVP RLKLSYKEML ESNNVITFNG LANSSSYHTF
        70         80         90        100        110        120
LLDEERSRLY VGAKDHIFSF DLVNIKDFQK IVWPVSYTRR DECKWAGKDI LKECANFIKV
       130        140        150        160        170        180
LKAYNQTHLY ACGTGAFHPI CTYIEIGHHP EDNIFKLENS HFENGRGKSP YDPKLLTASL
       190        200        210        220        230        240
LIDGELYSGT AADFMGRDFA IFRTLGHHHP IRTEQHDSRW LNDPKFISAH LISESDNPED
       250        260        270        280        290        300
DKVYFFFREN AIDGEHSGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG
       310        320        330        340        350        360
IDTHFDELQD VFLMNFKDPK NPVVYGVFTT SSNIFKGSAV CMYSMSDVRR VFLGPYAHRD
       370        380        390        400        410        420
GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDDVI TFARSHPAMY NPVFPMNNRP
       430        440        450        460        470        480
IVIKTDVNYQ FTQIVVDRVD AEDGQYDVMF IGTDVGTVLK VVSIPKETWY DLEEVLLEEM
       490        500        510        520        530        540
TVFREPTAIS AMELSTKQQQ LYIGSTAGVA QLPLHRCDIY GKACAECCLA RDPYCAWDGS
       550        560        570        580        590        600
ACSRYFPTAK RRTRRQDIRN GDPLTHCSDL HHDNHHGHSP EERIIYGVEN SSTFLECSPK
       610        620        630        640        650        660
SQRALVYWQF QRRNEERKEE IRVDDHIIRT DQGLLLRSLQ QKDSGNYLCH AVEHGFIQTL
       670        680        690        700        710        720
LKVTLEVIDT EHLEELLHKD DDGDGSKTKE MSNSMTPSQK VWYRDFMQLI NHPNLNTMDE
       730        740        750        760        770
FCEQVWKRDR KQRRQRPGHT PGNSNKWKHL QENKKGRNRR THEFERAPRS V

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q14563-21-unknown	NYQNGK...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q14563-556-unknown	QDIRNG...	556	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26644
Q14563-556-unknown	QDIRNG...	556	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26914
Q14563-556-unknown	QDIRNG...	556	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27212
Q14563-556-unknown	QDIRNG...	556	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9805
Q14563-556-unknown	QDIRNG...	556	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27062
Q14563-556-unknown	QDIRNG...	556	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27359

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLSYKE	37	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000402093
...EIGHHP	149	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000391900
...RRTRRQ	555	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26644
...RRTRRQ	555	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26914
...RRTRRQ	555	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27212
...RRTRRQ	555	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9805
...RRTRRQ	555	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27062
...RRTRRQ	555	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27359
...APRSV	771	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_HUMAN	555	TRRQ.\|.QDIR	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	555	TRRQ.\|.QDIR	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	555	TRRQ.\|.QDIR	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	555	TRRQ.\|.QDIR	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	555	TRRQ.\|.QDIR	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	555	TRRQ.\|.QDIR	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)