Q9Y5R2: Matrix metalloproteinase-24

General Information

Protein names	- Matrix metalloproteinase-24 - MMP-24 - 3.4.24.- - Membrane-type matrix metalloproteinase 5 - MT-MMP 5 - MTMMP5 - Membrane-type-5 matrix metalloproteinase - MT5-MMP - MT5MMP - Processed matrix metalloproteinase-24
Gene names	MMP24
Organism	Homo sapiens
Protease Family	M10.023
Protease ID	M10.023
Chromosome location
UniProt ID	Q9Y5R2

2 N-termini

3 C-termini

6 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MPRSRGGRAA PGPPPPPPPP GQAPRWSRWR VPGRLLLLLL PALCCLPGAA RAAAAAAGAG
        70         80         90        100        110        120
NRAAVAVAVA RADEAEAPFA GQNWLKSYGY LLPYDSRASA LHSAKALQSA VSTMQQFYGI
       130        140        150        160        170        180
PVTGVLDQTT IEWMKKPRCG VPDHPHLSRR RRNKRYALTG QKWRQKHITY SIHNYTPKVG
       190        200        210        220        230        240
ELDTRKAIRQ AFDVWQKVTP LTFEEVPYHE IKSDRKEADI MIFFASGFHG DSSPFDGEGG
       250        260        270        280        290        300
FLAHAYFPGP GIGGDTHFDS DEPWTLGNAN HDGNDLFLVA VHELGHALGL EHSSDPSAIM
       310        320        330        340        350        360
APFYQYMETH NFKLPQDDLQ GIQKIYGPPA EPLEPTRPLP TLPVRRIHSP SERKHERQPR
       370        380        390        400        410        420
PPRPPLGDRP STPGTKPNIC DGNFNTVALF RGEMFVFKDR WFWRLRNNRV QEGYPMQIEQ
       430        440        450        460        470        480
FWKGLPARID AAYERADGRF VFFKGDKYWV FKEVTVEPGY PHSLGELGSC LPREGIDTAL
       490        500        510        520        530        540
RWEPVGKTYF FKGERYWRYS EERRATDPGY PKPITVWKGI PQAPQGAFIS KEGYYTYFYK
       550        560        570        580        590        600
GRDYWKFDNQ KLSVEPGYPR NILRDWMGCN QKEVERRKER RLPQDDVDIM VTINDVPGSV
       610        620        630        640
NAVAVVIPCI LSLCILVLVY TIFQFKNKTG PQPVTYYKRP VQEWV

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 6 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9Y5R2-53-unknown	AAAAAG...	53	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5R2-156-unknown	YALTGQ...	156	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5R2-156-unknown	YALTGQ...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26664
Q9Y5R2-156-unknown	YALTGQ...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26936
Q9Y5R2-156-unknown	YALTGQ...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27234
Q9Y5R2-156-unknown	YALTGQ...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9858
Q9Y5R2-156-unknown	YALTGQ...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27086
Q9Y5R2-156-unknown	YALTGQ...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27381
Q9Y5R2-156-unknown	YALTGQ...	156	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RRNKRY	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26664
...RRNKRY	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26936
...RRNKRY	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27234
...RRNKRY	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9858
...RRNKRY	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27086
...RRNKRY	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27381
...VQEWV	645	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_HUMAN	155	NKRY.\|.YALT	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	155	NKRY.\|.YALT	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	155	NKRY.\|.YALT	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	155	NKRY.\|.YALT	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	155	NKRY.\|.YALT	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	155	NKRY.\|.YALT	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KISS1_HUMAN	118	SFGL.\|.LRFG	inferred from experiment	unknown	MEROPS	Sato H	Takino T et al.:Cleavage of metastasis suppress... (M10.014)	12879005,