O43184: Disintegrin and metalloproteinase domain-containing protein 12

General Information

Protein names	- Disintegrin and metalloproteinase domain-containing protein 12 - ADAM 12 - 3.4.24.- - Meltrin-alpha
Gene names	ADAM12
Organism	Homo sapiens
Protease Family
Protease ID	M12.212
Chromosome location
UniProt ID	O43184

3 N-termini

2 C-termini

5 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Disintegrin and metalloproteinase domain-containing protein 12 - Isoform 3 of Disintegrin and metalloproteinase domain-containing protein 12 - Isoform 4 of Disintegrin and metalloproteinase domain-containing protein 12

Sequence View

        10         20         30         40         50         60
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG DLWIPVKSFD
        70         80         90        100        110        120
SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTVILGHCY
       130        140        150        160        170        180
YHGHVRGYSD SAVSLSTCSG LRGLIVFENE SYVLEPMKSA TNRYKLFPAK KLKSVRGSCG
       190        200        210        220        230        240
SHHNTPNLAA KNVFPPPSQT WARRHKRETL KATKYVELVI VADNREFQRQ GKDLEKVKQR
       250        260        270        280        290        300
LIEIANHVDK FYRPLNIRIV LVGVEVWNDM DKCSVSQDPF TSLHEFLDWR KMKLLPRKSH
       310        320        330        340        350        360
DNAQLVSGVY FQGTTIGMAP IMSMCTADQS GGIVMDHSDN PLGAAVTLAH ELGHNFGMNH
       370        380        390        400        410        420
DTLDRGCSCQ MAVEKGGCIM NASTGYPFPM VFSSCSRKDL ETSLEKGMGV CLFNLPEVRE
       430        440        450        460        470        480
SFGGQKCGNR FVEEGEECDC GEPEECMNRC CNATTCTLKP DAVCAHGLCC EDCQLKPAGT
       490        500        510        520        530        540
ACRDSSNSCD LPEFCTGASP HCPANVYLHD GHSCQDVDGY CYNGICQTHE QQCVTLWGPG
       550        560        570        580        590        600
AKPAPGICFE RVNSAGDPYG NCGKVSKSSF AKCEMRDAKC GKIQCQGGAS RPVIGTNAVS
       610        620        630        640        650        660
IETNIPLQQG GRILCRGTHV YLGDDMPDPG LVLAGTKCAD GKICLNRQCQ NISVFGVHEC
       670        680        690        700        710        720
AMQCHGRGVC NNRKNCHCEA HWAPPFCDKF GFGGSTDSGP IRQADNQGLT IGILVTILCL
       730        740        750        760        770        780
LAAGFVVYLK RKTLIRLLFT NKKTTIEKLR CVRPSRPPRG FQPCQAHLGH LGKGLMRKPP
       790        800        810        820        830        840
DSYPPKDNPR RLLQCQNVDI SRPLNGLNVP QPQSTQRVLP PLHRAPRAPS VPARPLPAKP
       850        860        870        880        890        900
ALRQAQGTCK PNPPQKPLPA DPLARTTRLT HALARTPGQW ETGLRLAPLR PAPQYPHQVP

RSTHTAYIK         10         20         30         40         50         60
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG DLWIPVKSFD
        70         80         90        100        110        120
SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTVILGHCY
       130        140        150        160        170        180
YHGHVRGYSD SAVSLSTCSG LRGLIVFENE SYVLEPMKSA TNRYKLFPAK KLKSVRGSCG
       190        200        210        220        230        240
SHHNTPNLAA KNVFPPPSQT WARRHKRETL KATKYVELVI VADNREFQRQ GKDLEKVKQR
       250        260        270        280        290        300
LIEIANHVDK FYRPLNIRIV LVGVEVWNDM DKCSVSQDPF TSLHEFLDWR KMKLLPRKSH
       310        320        330        340        350        360
DNAQLVSGVY FQGTTIGMAP IMSMCTADQS GGIVMDHSDN PLGAAVTLAH ELGHNFGMNH
       370        380        390        400        410        420
DTLDRGCSCQ MAVEKGGCIM NASTGYPFPM VFSSCSRKDL ETSLEKGMGV CLFNLPEVRE
       430        440        450        460        470        480
SFGGQKCGNR FVEEGEECDC GEPEECMNRC CNATTCTLKP DAVCAHGLCC EDCQLKPAGT
       490        500        510        520        530        540
ACRDSSNSCD LPEFCTGASP HCPANVYLHD GHSCQDVDGY CYNGICQTHE QQCVTLWGPG
       550        560        570        580        590        600
AKPAPGICFE RVNSAGDPYG NCGKVSKSSF AKCEMRDAKC GKIQCQGGAS RPVIGTNAVS
       610        620        630        640        650        660
IETNIPLQQG GRILCRGTHV YLGDDMPDPG LVLAGTKCAD GKICLNRQCQ NISVFGVHEC
       670        680        690        700        710        720
AMQCHGRGVC NNRKNCHCEA HWAPPFCDKF GFGGSTDSGP IRQADNQGLT IGILVTILCL
       730        740        750        760        770        780
LAAGFVVYLK RKTLIRLLFT NKKTTIEKLR CVRPSRPPRG FQPCQAHLGH LGKGLMRKPP
       790        800        810        820        830        840
DSYPPKDNPR RLLQCQNVDI SRPLNGLNVP QPQSTQRVLP PLHRAPRAPS VPARPLPAKP
       850        860        870        880        890        900
ALRQAQGTCK PNPPQKPLPA DPLARTTRLT HALARTPGQW ETGLRLAPLR PAPQYPHQVP

RSTHTAYIK         10         20         30         40         50         60
MAARPLPVSP ARALLLALAG ALLAPCEARG VSLWNQGRAD EVVSASVGSG DLWIPVKSFD
        70         80         90        100        110        120
SKNHPEVLNI RLQRESKELI INLERNEGLI ASSFTETHYL QDGTDVSLAR NYTVILGHCY
       130        140        150        160        170        180
YHGHVRGYSD SAVSLSTCSG LRGLIVFENE SYVLEPMKSA TNRYKLFPAK KLKSVRGSCG
       190        200        210        220        230        240
SHHNTPNLAA KNVFPPPSQT WARRHKRETL KATKYVELVI VADNREFQRQ GKDLEKVKQR
       250        260        270        280        290        300
LIEIANHVDK FYRPLNIRIV LVGVEVWNDM DKCSVSQDPF TSLHEFLDWR KMKLLPRKSH
       310        320        330        340        350        360
DNAQLVSGVY FQGTTIGMAP IMSMCTADQS GGIVMDHSDN PLGAAVTLAH ELGHNFGMNH
       370        380        390        400        410        420
DTLDRGCSCQ MAVEKGGCIM NASTGYPFPM VFSSCSRKDL ETSLEKGMGV CLFNLPEVRE
       430        440        450        460        470        480
SFGGQKCGNR FVEEGEECDC GEPEECMNRC CNATTCTLKP DAVCAHGLCC EDCQLKPAGT
       490        500        510        520        530        540
ACRDSSNSCD LPEFCTGASP HCPANVYLHD GHSCQDVDGY CYNGICQTHE QQCVTLWGPG
       550        560        570        580        590        600
AKPAPGICFE RVNSAGDPYG NCGKVSKSSF AKCEMRDAKC GKIQCQGGAS RPVIGTNAVS
       610        620        630        640        650        660
IETNIPLQQG GRILCRGTHV YLGDDMPDPG LVLAGTKCAD GKICLNRQCQ NISVFGVHEC
       670        680        690        700        710        720
AMQCHGRGVC NNRKNCHCEA HWAPPFCDKF GFGGSTDSGP IRQADNQGLT IGILVTILCL
       730        740        750        760        770        780
LAAGFVVYLK RKTLIRLLFT NKKTTIEKLR CVRPSRPPRG FQPCQAHLGH LGKGLMRKPP
       790        800        810        820        830        840
DSYPPKDNPR RLLQCQNVDI SRPLNGLNVP QPQSTQRVLP PLHRAPRAPS VPARPLPAKP
       850        860        870        880        890        900
ALRQAQGTCK PNPPQKPLPA DPLARTTRLT HALARTPGQW ETGLRLAPLR PAPQYPHQVP

RSTHTAYIK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O43184-1-unknown	MAARPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66251
O43184-1-unknown	MAARPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66252
O43184-1-unknown	MAARPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66253
O43184-29-unknown	RGVSLW...	29	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43184-29-unknown	RGVSLW...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114566
O43184-29-unknown	RGVSLW...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114567
O43184-29-unknown	RGVSLW...	29	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114568
O43184-208-unknown	ETLKAT...	208	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43184-208-unknown	ETLKAT...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26942
O43184-208-unknown	ETLKAT...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27241
O43184-208-unknown	ETLKAT...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26801
O43184-208-unknown	ETLKAT...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9659
O43184-208-unknown	ETLKAT...	208	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27093
O43184-208-unknown	ETLKAT...	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116037
O43184-208-unknown	ETLKAT...	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116038
O43184-208-unknown	ETLKAT...	208	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116039
O43184-208-unknown	ETLKAT...	208	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRHKRE	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26942
...RRHKRE	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27241
...RRHKRE	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26801
...RRHKRE	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9659
...RRHKRE	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27093
...RRHKRE	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130020
...RRHKRE	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130021
...RRHKRE	207	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130162
...TAYIK	909	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	207	HKRE.\|.ETLK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	207	HKRE.\|.ETLK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	207	HKRE.\|.ETLK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	207	HKRE.\|.ETLK	inferred from experiment	unknown	MEROPS	Wewer UM	Loechel F et al.:Human ADAM 12 (meltrin alpha) i... (S08.071)	9642263,
PCSK6_HUMAN	207	HKRE.\|.ETLK	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)