TopFIND 4.0

P01270: Parathyroid hormone

General Information

Protein names	- Parathyroid hormone - PTH - Parathormone - Parathyrin
Gene names	PTH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01270

9

N-termini

10

C-termini

15

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MIPAKDMAKV MIVMLAICFL TKSDGKSVKK RSVSEIQLMH NLGKHLNSME RVEWLRKKLQ
70 80 90 100 110
DVHNFVALGA PLAPRDAGSQ RPRKKEDNVL VESHEKSLGE ADKADVNVLT KAKSQ

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 10 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P01270-32-unknown	SVSEIQ...	32		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P01270-32-unknown	SVSEIQ...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26967
P01270-32-unknown	SVSEIQ...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27263
P01270-32-unknown	SVSEIQ...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16258
P01270-32-unknown	SVSEIQ...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26554
P01270-32-unknown	SVSEIQ...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26822
P01270-32-unknown	SVSEIQ...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9689
P01270-32-unknown	SVSEIQ...	32		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27114
P01270-47-unknown	NSMERV...	47		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17005
P01270-48-unknown	SMERVE...	48		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17006
P01270-49-unknown	MERVEW...	49		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17007
P01270-55-unknown	LRKKLQ...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17008
P01270-58-unknown	KLQDVH...	58		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17009
P01270-61-unknown	DVHNFV...	61		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17010
P01270-62-unknown	VHNFVA...	62		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17011
P01270-65-unknown	FVALGA...	65		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17012

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...SVKKRS	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26967
	...SVKKRS	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27263
	...SVKKRS	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16258
	...SVKKRS	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26554
	...SVKKRS	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26822
	...SVKKRS	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9689
	...SVKKRS	31	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27114
	...LGKHLN	46	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17005
	...GKHLNS	47	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17006
	...KHLNSM	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17007
	...ERVEWL	54	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17008
	...EWLRKK	57	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17009
	...RKKLQD	60	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17010
	...KKLQDV	61	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17011
	...QDVHNF	64	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17012
	...KAKSQ	115	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	31	KKRS.\|.SVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	31	KKRS.\|.SVSE	inferred from experiment	unknown	MEROPS		Merops PCSK7_HUMAN -> PTHY_HUMAN @31
KLK4_HUMAN	31	KKRS.\|.SVSE	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
NEC2_HUMAN	31	KKRS.\|.SVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	31	KKRS.\|.SVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	31	KKRS.\|.SVSE	inferred from experiment	unknown	MEROPS	Seidah NG	Hendy GN et al.:Proparathyroid hormone is prefe... (S08.071)	7721880,
PCSK6_HUMAN	31	KKRS.\|.SVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
MEP1A_HUMAN	46	KHLN.\|.NSME	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	47	HLNS.\|.SMER	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	48	LNSM.\|.MERV	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	54	VEWL.\|.LRKK	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	57	LRKK.\|.KLQD	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	60	KLQD.\|.DVHN	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	61	LQDV.\|.VHNF	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,
MEP1A_HUMAN	64	VHNF.\|.FVAL	inferred from experiment	unknown	MEROPS	Bond JS	Bylander JE et al.:Human and mouse homo-oligomeric... (M12.002)	17976009,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)