P05019: Insulin-like growth factor I

General Information

Protein names	- Insulin-like growth factor I - IGF-I - Mechano growth factor - MGF - Somatomedin-C
Gene names	IGF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05019

8 N-termini

6 C-termini

10 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Insulin-like growth factor I - Isoform 3 of Insulin-like growth factor I - Isoform 4 of Insulin-like growth factor I

Sequence View

        10         20         30         40         50         60
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD
        70         80         90        100        110        120
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS
       130        140        150        160        170        180
VRAQRHTDMP KTQKYQPPST NKNTKSQRRK GWPKTHPGGE QKEGTEASLQ IRGKKKEQRR
       190
EIGSRNAECR GKKGK         10         20         30         40         50         60
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD
        70         80         90        100        110        120
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS
       130        140        150        160        170        180
VRAQRHTDMP KTQKYQPPST NKNTKSQRRK GWPKTHPGGE QKEGTEASLQ IRGKKKEQRR
       190
EIGSRNAECR GKKGK         10         20         30         40         50         60
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD
        70         80         90        100        110        120
ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS
       130        140        150        160        170        180
VRAQRHTDMP KTQKYQPPST NKNTKSQRRK GWPKTHPGGE QKEGTEASLQ IRGKKKEQRR
       190
EIGSRNAECR GKKGK

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 10 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05019-1-unknown	MGKISS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77631
P05019-1-unknown	MGKISS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt77633
P05019-22-unknown	VKMHTM...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05019-22-unknown	VKMHTM...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112860
P05019-22-unknown	VKMHTM...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112859
P05019-22-unknown	VKMHTM...	22	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112861
P05019-49-unknown	GPETLC...	49	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05019-49-unknown	GPETLC...	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115610
P05019-49-unknown	GPETLC...	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115609
P05019-49-unknown	GPETLC...	49	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115611
P05019-114-unknown	PAKSAR...	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3342
P05019-114-unknown	PAKSAR...	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142268
P05019-114-unknown	PAKSAR...	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143153
P05019-114-unknown	PAKSAR...	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143154
P05019-115-unknown	AKSARS...	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3346
P05019-115-unknown	AKSARS...	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143212
P05019-116-unknown	KSARSV...	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3350
P05019-116-unknown	KSARSV...	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143269
P05019-117-unknown	SARSVR...	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3354
P05019-117-unknown	SARSVR...	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143307
P05019-120-unknown	SVRAQR...	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26981
P05019-120-unknown	SVRAQR...	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27277
P05019-120-unknown	SVRAQR...	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26570
P05019-120-unknown	SVRAQR...	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26836
P05019-120-unknown	SVRAQR...	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9691
P05019-120-unknown	SVRAQR...	120	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27128
P05019-120-unknown	SVRAQR...	120	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143473

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CAPLKP	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3342
...CAPLKP	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125458
...CAPLKP	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126375
...CAPLKP	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126377
...APLKPA	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3346
...APLKPA	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125517
...APLKPA	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126438
...APLKPA	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126439
...PLKPAK	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3350
...PLKPAK	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125578
...PLKPAK	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126499
...PLKPAK	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126501
...LKPAKS	116	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3354
...LKPAKS	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125629
...LKPAKS	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126537
...LKPAKS	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126538
...PAKSAR	118	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PAKSAR	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91570
...PAKSAR	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91569
...PAKSAR	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91571
...AKSARS	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26981
...AKSARS	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27277
...AKSARS	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26570
...AKSARS	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26836
...AKSARS	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9691
...AKSARS	119	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27128
...AKSARS	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125784
...AKSARS	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126706
...AKSARS	119	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126708

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	113	PLKP.\|.PAKS	inferred from experiment	unknown	MEROPS	Briand G	Authier F et al.:Endosomal proteolysis of insuli... (C01.060)	16051222,
CATB_HUMAN	114	LKPA.\|.AKSA	inferred from experiment	unknown	MEROPS	Briand G	Authier F et al.:Endosomal proteolysis of insuli... (C01.060)	16051222,
CATB_HUMAN	115	KPAK.\|.KSAR	inferred from experiment	unknown	MEROPS	Briand G	Authier F et al.:Endosomal proteolysis of insuli... (C01.060)	16051222,
CATB_HUMAN	116	PAKS.\|.SARS	inferred from experiment	unknown	MEROPS	Briand G	Authier F et al.:Endosomal proteolysis of insuli... (C01.060)	16051222,
PCSK5_HUMAN	119	SARS.\|.SVRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	119	SARS.\|.SVRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	119	SARS.\|.SVRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	119	SARS.\|.SVRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	119	SARS.\|.SVRA	inferred from experiment	unknown	MEROPS	Steiner DF	Duguay SJ et al.:Mutational analysis of the insu... (S08.071)	7615562,
FURIN_HUMAN	119	SARS.\|.SVRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	119	SARS.\|.SVRA	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)