P08514: Integrin alpha-IIb
Protein names | - Integrin alpha-IIb - GPalpha IIb - GPIIb - Platelet membrane glycoprotein IIb - CD41 - Integrin alpha-IIb heavy chain - Integrin alpha-IIb light chain, form 1 - Integrin alpha-IIb light chain, form 2 |
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Gene names | ITGA2B |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P08514 |
9
N-termini
3
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MARALCPLQA LWLLEWVLLL LGPCAAPPAW ALNLDPVQLT FYAGPNGSQF GFSLDFHKDS
70 80 90 100 110 120
HGRVAIVVGA PRTLGPSQEE TGGVFLCPWR AEGGQCPSLL FDLRDETRNV GSQTLQTFKA
130 140 150 160 170 180
RQGLGASVVS WSDVIVACAP WQHWNVLEKT EEAEKTPVGS CFLAQPESGR RAEYSPCRGN
190 200 210 220 230 240
TLSRIYVEND FSWDKRYCEA GFSSVVTQAG ELVLGAPGGY YFLGLLAQAP VADIFSSYRP
250 260 270 280 290 300
GILLWHVSSQ SLSFDSSNPE YFDGYWGYSV AVGEFDGDLN TTEYVVGAPT WSWTLGAVEI
310 320 330 340 350 360
LDSYYQRLHR LRGEQMASYF GHSVAVTDVN GDGRHDLLVG APLYMESRAD RKLAEVGRVY
370 380 390 400 410 420
LFLQPRGPHA LGAPSLLLTG TQLYGRFGSA IAPLGDLDRD GYNDIAVAAP YGGPSGRGQV
430 440 450 460 470 480
LVFLGQSEGL RSRPSQVLDS PFPTGSAFGF SLRGAVDIDD NGYPDLIVGA YGANQVAVYR
490 500 510 520 530 540
AQPVVKASVQ LLVQDSLNPA VKSCVLPQTK TPVSCFNIQM CVGATGHNIP QKLSLNAELQ
550 560 570 580 590 600
LDRQKPRQGR RVLLLGSQQA GTTLNLDLGG KHSPICHTTM AFLRDEADFR DKLSPIVLSL
610 620 630 640 650 660
NVSLPPTEAG MAPAVVLHGD THVQEQTRIV LDCGEDDVCV PQLQLTASVT GSPLLVGADN
670 680 690 700 710 720
VLELQMDAAN EGEGAYEAEL AVHLPQGAHY MRALSNVEGF ERLICNQKKE NETRVVLCEL
730 740 750 760 770 780
GNPMKKNAQI GIAMLVSVGN LEEAGESVSF QLQIRSKNSQ NPNSKIVLLD VPVRAEAQVE
790 800 810 820 830 840
LRGNSFPASL VVAAEEGERE QNSLDSWGPK VEHTYELHNN GPGTVNGLHL SIHLPGQSQP
850 860 870 880 890 900
SDLLYILDIQ PQGGLQCFPQ PPVNPLKVDW GLPIPSPSPI HPAHHKRDRR QIFLPEPEQP
910 920 930 940 950 960
SRLQDPVLVS CDSAPCTVVQ CDLQEMARGQ RAMVTVLAFL WLPSLYQRPL DQFVLQSHAW
970 980 990 1000 1010 1020
FNVSSLPYAV PPLSLPRGEA QVWTQLLRAL EERAIPIWWV LVGVLGGLLL LTILVLAMWK
1030
VGFFKRNRPP LEEDDEEGE
Isoforms
- Isoform 2 of Integrin alpha-IIb - Isoform 3 of Integrin alpha-IIbSequence View
10 20 30 40 50 60
MARALCPLQA LWLLEWVLLL LGPCAAPPAW ALNLDPVQLT FYAGPNGSQF GFSLDFHKDS
70 80 90 100 110 120
HGRVAIVVGA PRTLGPSQEE TGGVFLCPWR AEGGQCPSLL FDLRDETRNV GSQTLQTFKA
130 140 150 160 170 180
RQGLGASVVS WSDVIVACAP WQHWNVLEKT EEAEKTPVGS CFLAQPESGR RAEYSPCRGN
190 200 210 220 230 240
TLSRIYVEND FSWDKRYCEA GFSSVVTQAG ELVLGAPGGY YFLGLLAQAP VADIFSSYRP
250 260 270 280 290 300
GILLWHVSSQ SLSFDSSNPE YFDGYWGYSV AVGEFDGDLN TTEYVVGAPT WSWTLGAVEI
310 320 330 340 350 360
LDSYYQRLHR LRGEQMASYF GHSVAVTDVN GDGRHDLLVG APLYMESRAD RKLAEVGRVY
370 380 390 400 410 420
LFLQPRGPHA LGAPSLLLTG TQLYGRFGSA IAPLGDLDRD GYNDIAVAAP YGGPSGRGQV
430 440 450 460 470 480
LVFLGQSEGL RSRPSQVLDS PFPTGSAFGF SLRGAVDIDD NGYPDLIVGA YGANQVAVYR
490 500 510 520 530 540
AQPVVKASVQ LLVQDSLNPA VKSCVLPQTK TPVSCFNIQM CVGATGHNIP QKLSLNAELQ
550 560 570 580 590 600
LDRQKPRQGR RVLLLGSQQA GTTLNLDLGG KHSPICHTTM AFLRDEADFR DKLSPIVLSL
610 620 630 640 650 660
NVSLPPTEAG MAPAVVLHGD THVQEQTRIV LDCGEDDVCV PQLQLTASVT GSPLLVGADN
670 680 690 700 710 720
VLELQMDAAN EGEGAYEAEL AVHLPQGAHY MRALSNVEGF ERLICNQKKE NETRVVLCEL
730 740 750 760 770 780
GNPMKKNAQI GIAMLVSVGN LEEAGESVSF QLQIRSKNSQ NPNSKIVLLD VPVRAEAQVE
790 800 810 820 830 840
LRGNSFPASL VVAAEEGERE QNSLDSWGPK VEHTYELHNN GPGTVNGLHL SIHLPGQSQP
850 860 870 880 890 900
SDLLYILDIQ PQGGLQCFPQ PPVNPLKVDW GLPIPSPSPI HPAHHKRDRR QIFLPEPEQP
910 920 930 940 950 960
SRLQDPVLVS CDSAPCTVVQ CDLQEMARGQ RAMVTVLAFL WLPSLYQRPL DQFVLQSHAW
970 980 990 1000 1010 1020
FNVSSLPYAV PPLSLPRGEA QVWTQLLRAL EERAIPIWWV LVGVLGGLLL LTILVLAMWK
1030
VGFFKRNRPP LEEDDEEGE
10 20 30 40 50 60
MARALCPLQA LWLLEWVLLL LGPCAAPPAW ALNLDPVQLT FYAGPNGSQF GFSLDFHKDS
70 80 90 100 110 120
HGRVAIVVGA PRTLGPSQEE TGGVFLCPWR AEGGQCPSLL FDLRDETRNV GSQTLQTFKA
130 140 150 160 170 180
RQGLGASVVS WSDVIVACAP WQHWNVLEKT EEAEKTPVGS CFLAQPESGR RAEYSPCRGN
190 200 210 220 230 240
TLSRIYVEND FSWDKRYCEA GFSSVVTQAG ELVLGAPGGY YFLGLLAQAP VADIFSSYRP
250 260 270 280 290 300
GILLWHVSSQ SLSFDSSNPE YFDGYWGYSV AVGEFDGDLN TTEYVVGAPT WSWTLGAVEI
310 320 330 340 350 360
LDSYYQRLHR LRGEQMASYF GHSVAVTDVN GDGRHDLLVG APLYMESRAD RKLAEVGRVY
370 380 390 400 410 420
LFLQPRGPHA LGAPSLLLTG TQLYGRFGSA IAPLGDLDRD GYNDIAVAAP YGGPSGRGQV
430 440 450 460 470 480
LVFLGQSEGL RSRPSQVLDS PFPTGSAFGF SLRGAVDIDD NGYPDLIVGA YGANQVAVYR
490 500 510 520 530 540
AQPVVKASVQ LLVQDSLNPA VKSCVLPQTK TPVSCFNIQM CVGATGHNIP QKLSLNAELQ
550 560 570 580 590 600
LDRQKPRQGR RVLLLGSQQA GTTLNLDLGG KHSPICHTTM AFLRDEADFR DKLSPIVLSL
610 620 630 640 650 660
NVSLPPTEAG MAPAVVLHGD THVQEQTRIV LDCGEDDVCV PQLQLTASVT GSPLLVGADN
670 680 690 700 710 720
VLELQMDAAN EGEGAYEAEL AVHLPQGAHY MRALSNVEGF ERLICNQKKE NETRVVLCEL
730 740 750 760 770 780
GNPMKKNAQI GIAMLVSVGN LEEAGESVSF QLQIRSKNSQ NPNSKIVLLD VPVRAEAQVE
790 800 810 820 830 840
LRGNSFPASL VVAAEEGERE QNSLDSWGPK VEHTYELHNN GPGTVNGLHL SIHLPGQSQP
850 860 870 880 890 900
SDLLYILDIQ PQGGLQCFPQ PPVNPLKVDW GLPIPSPSPI HPAHHKRDRR QIFLPEPEQP
910 920 930 940 950 960
SRLQDPVLVS CDSAPCTVVQ CDLQEMARGQ RAMVTVLAFL WLPSLYQRPL DQFVLQSHAW
970 980 990 1000 1010 1020
FNVSSLPYAV PPLSLPRGEA QVWTQLLRAL EERAIPIWWV LVGVLGGLLL LTILVLAMWK
1030
VGFFKRNRPP LEEDDEEGE
Protein Neighborhood
Domains & Features
9 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P08514-1-unknown | MARALC... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78124 | |||
P08514-1-unknown | MARALC... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78125 | |||
P08514-32-unknown | LNLDPV... | 32 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P08514-32-unknown | LNLDPV... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114947 | |||
P08514-32-unknown | LNLDPV... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114948 | |||
P08514-401-unknown | GYNDIA... | 401 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177905 | |||
P08514-401-unknown | GYNDIA... | 401 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177906 | |||
P08514-401- | GYNDIA... | 401 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P08514-668-unknown | AANEGE... | 668 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177902 | |||
P08514-668-unknown | AANEGE... | 668 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177903 | |||
P08514-668- | AANEGE... | 668 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P08514-891-Pyrrolidone carboxylic acid | QIFLPE... | 891 | pyrrolidone carboxylic acid- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P08514-891-Pyrrolidone carboxylic acid | QIFLPE... | 891 | pyrrolidone carboxylic acid- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116391 | ||
P08514-891-unknown | QIFLPE... | 891 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27141 | |||
P08514-891-unknown | QIFLPE... | 891 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26994 | |||
P08514-891-unknown | QIFLPE... | 891 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27293 | |||
P08514-891-unknown | QIFLPE... | 891 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26849 | |||
P08514-891-unknown | QIFLPE... | 891 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156833 | |||
P08514-903-unknown | LQDPVL... | 903 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P08514-903-unknown | LQDPVL... | 903 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt116395 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AHHKRD | 887 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...AHHKRD | 887 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93480 | |||
...AHHKRD | 887 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93481 | |||
...KRDRRQ | 890 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27141 | |||
...KRDRRQ | 890 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26994 | |||
...KRDRRQ | 890 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27293 | |||
...KRDRRQ | 890 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26849 | |||
...KRDRRQ | 890 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140326 | |||
...KRDRRQ | 890 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140327 | |||
...DEEGE | 1039 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...DEEGE | 1039 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73742 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
PCSK6_HUMAN | 890 | DRRQ.|.QIFL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
PCSK5_HUMAN | 890 | DRRQ.|.QIFL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
PCSK7_HUMAN | 890 | DRRQ.|.QIFL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
PCSK4_HUMAN | 890 | DRRQ.|.QIFL | inferred from experiment | unknown | MEROPS | Strongin AY | Remacle AG et al.:Substrate cleavage analysis of ... (S08.071) | 18505722, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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