P12272: Parathyroid hormone-related protein

General Information

Protein names	- Parathyroid hormone-related protein - PTH-rP - PTHrP - Parathyroid hormone-like protein - PLP - PTHrP1-36] - PTHrP38-94] - Osteostatin - PTHrP107-139]
Gene names	PTHLH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12272

8 N-termini

9 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL
        70         80         90        100        110        120
HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK
       130        140        150        160        170
TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSRRH

Isoforms

- Isoform 2 of Parathyroid hormone-related protein - Isoform 3 of Parathyroid hormone-related protein

Sequence View

        10         20         30         40         50         60
MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL
        70         80         90        100        110        120
HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK
       130        140        150        160        170
TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSRRH         10         20         30         40         50         60
MQRRLVQQWS VAVFLLSYAV PSCGRSVEGL SRRLKRAVSE HQLLHDKGKS IQDLRRRFFL
        70         80         90        100        110        120
HHLIAEIHTA EIRATSEVSP NSKPSPNTKN HPVRFGSDDE GRYLTQETNK VETYKEQPLK
       130        140        150        160        170
TPGKKKKGKP GKRKEQEKKK RRTRSAWLDS GVTGSGLEGD HLSDTSTTSL ELDSRRH

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P12272-1-unknown	MQRRLV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86478
P12272-1-unknown	MQRRLV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt86479
P12272-25-unknown	RSVEGL...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12272-25-unknown	RSVEGL...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113739
P12272-25-unknown	RSVEGL...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113740
P12272-37-unknown	AVSEHQ...	37	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P12272-37-unknown	AVSEHQ...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9731
P12272-37-unknown	AVSEHQ...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27150
P12272-37-unknown	AVSEHQ...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27003
P12272-37-unknown	AVSEHQ...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27302
P12272-37-unknown	AVSEHQ...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16300
P12272-37-unknown	AVSEHQ...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26591
P12272-37-unknown	AVSEHQ...	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26858
P12272-37-unknown	AVSEHQ...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115312
P12272-37-unknown	AVSEHQ...	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115313
P12272-60-unknown	LHHLIA...	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16205
P12272-60-unknown	LHHLIA...	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139906
P12272-60-unknown	LHHLIA...	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139907
P12272-61-unknown	HHLIAE...	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3629
P12272-61-unknown	HHLIAE...	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139975
P12272-61-unknown	HHLIAE...	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139977
P12272-63-unknown	LIAEIH...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18708
P12272-63-unknown	LIAEIH...	63	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17321
P12272-63-unknown	LIAEIH...	63	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140152
P12272-63-unknown	LIAEIH...	63	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140153
P12272-149-unknown	DSGVTG...	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27409
P12272-149-unknown	DSGVTG...	149	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144665
P12272-149-unknown	DSGVTG...	149	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144666
P12272-164-unknown	DTSTTS...	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27412
P12272-164-unknown	DTSTTS...	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145292

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRLKRA	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9731
...RRLKRA	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27150
...RRLKRA	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27003
...RRLKRA	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27302
...RRLKRA	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16300
...RRLKRA	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26591
...RRLKRA	36	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26858
...RRLKRA	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121093
...RRLKRA	36	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121094
...RRRFFL	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16205
...RRRFFL	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123011
...RRRFFL	59	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123012
...RRFFLH	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3629
...RRFFLH	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123081
...RRFFLH	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123083
...FFLHHL	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18708
...FFLHHL	62	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17321
...FFLHHL	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123260
...FFLHHL	62	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123261
...RSAWLD	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27409
...RSAWLD	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127932
...RSAWLD	148	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127933
...GDHLSD	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27412
...GDHLSD	163	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128582
...GDHLSD	163	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128583
...TSLELD	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27415
...TSLELD	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155297
...TSLELD	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155298
...ELDSRR	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt82096
...ELDSRR	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91808
...DSRRH	177	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	36	LKRA.\|.AVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	36	LKRA.\|.AVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	36	LKRA.\|.AVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	36	LKRA.\|.AVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
KLK4_HUMAN	36	LKRA.\|.AVSE	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
NEC2_HUMAN	36	LKRA.\|.AVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	36	LKRA.\|.AVSE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
KLK3_HUMAN	59	RFFL.\|.LHHL	inferred from experiment	unknown	MEROPS		Merops KLK3_HUMAN -> PTHR_HUMAN @59
CATB_HUMAN	60	FFLH.\|.HHLI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1B_HUMAN	62	LHHL.\|.LIAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	62	LHHL.\|.LIAE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
PHEX_HUMAN	148	AWLD.\|.DSGV	inferred from experiment	unknown	MEROPS	Crine P	Boileau G et al.:Characterization of PHEX endope... (M13.091)	11311133,
PHEX_HUMAN	163	HLSD.\|.DTST	inferred from experiment	unknown	MEROPS	Crine P	Boileau G et al.:Characterization of PHEX endope... (M13.091)	11311133,
PHEX_HUMAN	172	LELD.\|.DSRR	inferred from experiment	unknown	MEROPS	Crine P	Boileau G et al.:Characterization of PHEX endope... (M13.091)	11311133,

TopFIND

P12272: Parathyroid hormone-related protein

General Information

8

N-termini

9

C-termini

14

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

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Protein Neighborhood

Domains & Features

8 N-termini - 9 C-termini - 14 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates