TopFIND 4.0

P78562: Phosphate-regulating neutral endopeptidase PHEX

General Information

Protein names
- Phosphate-regulating neutral endopeptidase PHEX
- 3.4.24.- {ECO:0000269|PubMed:18597632, ECO:0000269|PubMed:9593714}
- Metalloendopeptidase homolog PEX
- Vitamin D-resistant hypophosphatemic rickets protein
- X-linked hypophosphatemia protein
- HYP
Gene names PHEX
Organism Homo sapiens
Protease Family M13.091
Protease ID M13.091
Chromosome location
UniProt ID P78562

2

N-termini

1

C-termini

0

Cleavages

16

Substrates

Sequence

        10         20         30         40         50         60 
MEAETGSSVE TGKKANRGTR IALVVFVGGT LVLGTILFLV SQGLLSLQAK QEYCLKPECI 
        70         80         90        100        110        120 
EAAAAILSKV NLSVDPCDNF FRFACDGWIS NNPIPEDMPS YGVYPWLRHN VDLKLKELLE 
       130        140        150        160        170        180 
KSISRRRDTE AIQKAKILYS SCMNEKAIEK ADAKPLLHIL RHSPFRWPVL ESNIGPEGVW 
       190        200        210        220        230        240 
SERKFSLLQT LATFRGQYSN SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDYLDNST 
       250        260        270        280        290        300 
EAKSYRDALY KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM 
       310        320        330        340        350        360 
NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDISPSENVV VRVPQYFKDL FRILGSERKK 
       370        380        390        400        410        420 
TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL PQWDKCVNFI ESALPYVVGK 
       430        440        450        460        470        480 
MFVDVYFQED KKEMMEELVE GVRWAFIDML EKENEWMDAG TKRKAKEKAR AVLAKVGYPE 
       490        500        510        520        530        540 
FIMNDTHVNE DLKAIKFSEA DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF 
       550        560        570        580        590        600 
YSASTNQIRF PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD 
       610        620        630        640        650        660 
PWWSTESEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL REAFRAYRKW 
       670        680        690        700        710        720 
INDRRQGLEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA AREQVQIGAH SPPQFRVNGA 
       730        740    
ISNFEEFQKA FNCPPNSTMN RGMDSCRLW

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 16 Substrates

N-termini

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SCRLW 749 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates