P05408: Neuroendocrine protein 7B2

General Information

Protein names	- Neuroendocrine protein 7B2 - Pituitary polypeptide - Secretogranin V - Secretogranin-5 - Secretory granule endocrine protein I - N-terminal peptide - C-terminal peptide
Gene names	SCG5
Organism	Homo sapiens
Protease Family
Protease ID	I21.001
Chromosome location
UniProt ID	P05408

4 N-termini

4 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVSRMVSTML SGLLFWLASG WTPAFAYSPR TPDRVSEADI QRLLHGVMEQ LGIARPRVEY
        70         80         90        100        110        120
PAHQAMNLVG PQSIEGGAHE GLQHLGPFGN IPNIVAELTG DNIPKDFSED QGYPDPPNPC
       130        140        150        160        170        180
PVGKTADDGC LENTPDTAEF SREFQLHQHL FDPEHDYPGL GKWNKKLLYE KMKGGERRKR
       190        200        210
RSVNPYLQGQ RLDNVVAKKS VPHFSDEDKD PE

Isoforms

- Isoform 2 of Neuroendocrine protein 7B2

Sequence View

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Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05408-1-unknown	MVSRMV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt65832
P05408-27-unknown	YSPRTP...	27	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05408-27-unknown	YSPRTP...	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114243
P05408-182-unknown	SVNPYL...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26985
P05408-182-unknown	SVNPYL...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27284
P05408-182-unknown	SVNPYL...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26574
P05408-182-unknown	SVNPYL...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26840
P05408-182-unknown	SVNPYL...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9712
P05408-182-unknown	SVNPYL...	182	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27132
P05408-182-unknown	SVNPYL...	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145925
P05408-200-unknown	SVPHFS...	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26576
P05408-200-unknown	SVPHFS...	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146555

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MKGGER	176	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MKGGER	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91819
...RRKRRS	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26985
...RRKRRS	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27284
...RRKRRS	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26574
...RRKRRS	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26840
...RRKRRS	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9712
...RRKRRS	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27132
...RRKRRS	181	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129222
...VVAKKS	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26576
...VVAKKS	199	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129861
...VVAKKS	199	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VVAKKS	199	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
...DKDPE	212	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DKDPE	212	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61450

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PCSK5_HUMAN	181	KRRS.\|.SVNP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	181	KRRS.\|.SVNP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	181	KRRS.\|.SVNP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	181	KRRS.\|.SVNP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	181	KRRS.\|.SVNP	inferred from experiment	unknown	MEROPS	Lindberg I	Hwang JR et al.:Inactivation of the 7B2 inhibit... (S08.071)	11677272,
PCSK6_HUMAN	181	KRRS.\|.SVNP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	199	AKKS.\|.SVPH	inferred from experiment	unknown	MEROPS	Lindberg I	Zhu X et al.:Internal cleavage of the inhibi... (S08.073)	8643504,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)