O60494: Cubilin
Protein names | - Cubilin - 460 kDa receptor - Intestinal intrinsic factor receptor - Intrinsic factor-cobalamin receptor - Intrinsic factor-vitamin B12 receptor |
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Gene names | CUBN |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O60494 |
4
N-termini
2
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MMNMSLPFLW SLLTLLIFAE VNGEAGELEL QRQKRSINLQ QPRMATERGN LVFLTGSAQN
70 80 90 100 110 120
IEFRTGSLGK IKLNDEDLSE CLHQIQKNKE DIIELKGSAI GLPQNISSQI YQLNSKLVDL
130 140 150 160 170 180
ERKFQGLQQT VDKKVCSSNP CQNGGTCLNL HDSFFCICPP QWKGPLCSAD VNECEIYSGT
190 200 210 220 230 240
PLSCQNGGTC VNTMGSYSCH CPPETYGPQC ASKYDDCEGG SVARCVHGIC EDLMREQAGE
250 260 270 280 290 300
PKYSCVCDAG WMFSPNSPAC TLDRDECSFQ PGPCSTLVQC FNTQGSFYCG ACPTGWQGNG
310 320 330 340 350 360
YICEDINECE INNGGCSVAP PVECVNTPGS SHCQACPPGY QGDGRVCTLT DICSVSNGGC
370 380 390 400 410 420
HPDASCSSTL GSLPLCTCLP GYTGNGYGPN GCVQLSNICL SHPCLNGQCI DTVSGYFCKC
430 440 450 460 470 480
DSGWTGVNCT ENINECLSNP CLNGGTCVDG VDSFSCECTR LWTGALCQVP QQVCGESLSG
490 500 510 520 530 540
INGSFSYRSP DVGYVHDVNC FWVIKTEMGK VLRITFTFFR LESMDNCPHE FLQVYDGDSS
550 560 570 580 590 600
SAFQLGRFCG SSLPHELLSS DNALYFHLYS EHLRNGRGFT VRWETQQPEC GGILTGPYGS
610 620 630 640 650 660
IKSPGYPGNY PPGRDCVWIV VTSPDLLVTF TFGTLSLEHH DDCNKDYLEI RDGPLYQDPL
670 680 690 700 710 720
LGKFCTTFSV PPLQTTGPFA RIHFHSDSQI SDQGFHITYL TSPSDLRCGG NYTDPEGELF
730 740 750 760 770 780
LPELSGPFTH TRQCVYMMKQ PQGEQIQINF THVELQCQSD SSQNYIEVRD GETLLGKVCG
790 800 810 820 830 840
NGTISHIKSI TNSVWIRFKI DASVEKASFR AVYQVACGDE LTGEGVIRSP FFPNVYPGER
850 860 870 880 890 900
TCRWTIHQPQ SQVILLNFTV FEIGSSAHCE TDYVEIGSSS ILGSPENKKY CGTDIPSFIT
910 920 930 940 950 960
SVYNFLYVTF VKSSSTENHG FMAKFSAEDL ACGEILTEST GTIQSPGHPN VYPHGINCTW
970 980 990 1000 1010 1020
HILVQPNHLI HLMFETFHLE FHYNCTNDYL EVYDTDSETS LGRYCGKSIP PSLTSSGNSL
1030 1040 1050 1060 1070 1080
MLVFVTDSDL AYEGFLINYE AISAATACLQ DYTDDLGTFT SPNFPNNYPN NWECIYRITV
1090 1100 1110 1120 1130 1140
RTGQLIAVHF TNFSLEEAIG NYYTDFLEIR DGGYEKSPLL GIFYGSNLPP TIISHSNKLW
1150 1160 1170 1180 1190 1200
LKFKSDQIDT RSGFSAYWDG SSTGCGGNLT TSSGTFISPN YPMPYYHSSE CYWWLKSSHG
1210 1220 1230 1240 1250 1260
SAFELEFKDF HLEHHPNCTL DYLAVYDGPS SNSHLLTQLC GDEKPPLIRS SGDSMFIKLR
1270 1280 1290 1300 1310 1320
TDEGQQGRGF KAEYRQTCEN VVIVNQTYGI LESIGYPNPY SENQHCNWTI RATTGNTVNY
1330 1340 1350 1360 1370 1380
TFLAFDLEHH INCSTDYLEL YDGPRQMGRY CGVDLPPPGS TTSSKLQVLL LTDGVGRREK
1390 1400 1410 1420 1430 1440
GFQMQWFVYG CGGELSGATG SFSSPGFPNR YPPNKECIWY IRTDPGSSIQ LTIHDFDVEY
1450 1460 1470 1480 1490 1500
HSRCNFDVLE IYGGPDFHSP RIAQLCTQRS PENPMQVSST GNELAIRFKT DLSINGRGFN
1510 1520 1530 1540 1550 1560
ASWQAVTGGC GGIFQAPSGE IHSPNYPSPY RSNTDCSWVI RVDRNHRVLL NFTDFDLEPQ
1570 1580 1590 1600 1610 1620
DSCIMAYDGL SSTMSRLART CGREQLANPI VSSGNSLFLR FQSGPSRQNR GFRAQFRQAC
1630 1640 1650 1660 1670 1680
GGHILTSSFD TVSSPRFPAN YPNNQNCSWI IQAQPPLNHI TLSFTHFELE RSTTCARDFV
1690 1700 1710 1720 1730 1740
EILDGGHEDA PLRGRYCGTD MPHPITSFSS ALTLRFVSDS SISAGGFHTT VTASVSACGG
1750 1760 1770 1780 1790 1800
TFYMAEGIFN SPGYPDIYPP NVECVWNIVS SPGNRLQLSF ISFQLEDSQD CSRDFVEIRE
1810 1820 1830 1840 1850 1860
GNATGHLVGR YCGNSFPLNY SSIVGHTLWV RFISDGSGSG TGFQATFMKI FGNDNIVGTH
1870 1880 1890 1900 1910 1920
GKVASPFWPE NYPHNSNYQW TVNVNASHVV HGRILEMDIE EIQNCYYDKL RIYDGPSIHA
1930 1940 1950 1960 1970 1980
RLIGAYCGTQ TESFSSTGNS LTFHFYSDSS ISGKGFLLEW FAVDAPDGVL PTIAPGACGG
1990 2000 2010 2020 2030 2040
FLRTGDAPVF LFSPGWPDSY SNRVDCTWLI QAPDSTVELN ILSLDIESHR TCAYDSLVIR
2050 2060 2070 2080 2090 2100
DGDNNLAQQL AVLCGREIPG PIRSTGEYMF IRFTSDSSVT RAGFNASFHK SCGGYLHADR
2110 2120 2130 2140 2150 2160
GIITSPKYPE TYPSNLNCSW HVLVQSGLTI AVHFEQPFQI PNGDSSCNQG DYLVLRNGPD
2170 2180 2190 2200 2210 2220
ICSPPLGPPG GNGHFCGSHA SSTLFTSDNQ MFVQFISDHS NEGQGFKIKY EAKSLACGGN
2230 2240 2250 2260 2270 2280
VYIHDADSAG YVTSPNHPHN YPPHADCIWI LAAPPETRIQ LQFEDRFDIE VTPNCTSNYL
2290 2300 2310 2320 2330 2340
ELRDGVDSDA PILSKFCGTS LPSSQWSSGE VMYLRFRSDN SPTHVGFKAK YSIAQCGGRV
2350 2360 2370 2380 2390 2400
PGQSGVVESI GHPTLPYRDN LFCEWHLQGL SGHYLTISFE DFNLQNSSGC EKDFVEIWDN
2410 2420 2430 2440 2450 2460
HTSGNILGRY CGNTIPDSID TSSNTAVVRF VTDGSVTASG FRLRFESSME ECGGDLQGSI
2470 2480 2490 2500 2510 2520
GTFTSPNYPN PNPHGRICEW RITAPEGRRI TLMFNNLRLA THPSCNNEHV IVFNGIRSNS
2530 2540 2550 2560 2570 2580
PQLEKLCSSV NVSNEIKSSG NTMKVIFFTD GSRPYGGFTA SYTSSEDAVC GGSLPNTPEG
2590 2600 2610 2620 2630 2640
NFTSPGYDGV RNYSRNLNCE WTLSNPNQGN SSISIHFEDF YLESHQDCQF DVLEFRVGDA
2650 2660 2670 2680 2690 2700
DGPLMWRLCG PSKPTLPLVI PYSQVWIHFV TNERVEHIGF HAKYSFTDCG GIQIGDSGVI
2710 2720 2730 2740 2750 2760
TSPNYPNAYD SLTHCSSLLE APQGHTITLT FSDFDIEPHT TCAWDSVTVR NGGSPESPII
2770 2780 2790 2800 2810 2820
GQYCGNSNPR TIQSGSNQLV VTFNSDHSLQ GGGFYATWNT QTLGCGGIFH SDNGTIRSPH
2830 2840 2850 2860 2870 2880
WPQNFPENSR CSWTAITHKS KHLEISFDNN FLIPSGDGQC QNSFVKVWAG TEEVDKALLA
2890 2900 2910 2920 2930 2940
TGCGNVAPGP VITPSNTFTA VFQSQEAPAQ GFSASFVSRC GSNFTGPSGY IISPNYPKQY
2950 2960 2970 2980 2990 3000
DNNMNCTYVI EANPLSVVLL TFVSFHLEAR SAVTGSCVND GVHIIRGYSV MSTPFATVCG
3010 3020 3030 3040 3050 3060
DEMPAPLTIA GPVLLNFYSN EQITDFGFKF SYRIISCGGV FNFSSGIITS PAYSYADYPN
3070 3080 3090 3100 3110 3120
DMHCLYTITV SDDKVIELKF SDFDVVPSTS CSHDYLAIYD GANTSDPLLG KFCGSKRPPN
3130 3140 3150 3160 3170 3180
VKSSNNSMLL VFKTDSFQTA KGWKMSFRQT LGPQQGCGGY LTGSNNTFAS PDSDSNGMYD
3190 3200 3210 3220 3230 3240
KNLNCVWIII APVNKVIHLT FNTFALEAAS TRQRCLYDYV KLYDGDSENA NLAGTFCGST
3250 3260 3270 3280 3290 3300
VPAPFISSGN FLTVQFISDL TLEREGFNAT YTIMDMPCGG TYNATWTPQN ISSPNSSDPD
3310 3320 3330 3340 3350 3360
VPFSICTWVI DSPPHQQVKI TVWALQLTSQ DCTQNYLQLQ DSPQGHGNSR FQFCGRNASA
3370 3380 3390 3400 3410 3420
VPVFYSSMST AMVIFKSGVV NRNSRMSFTY QIADCNRDYH KAFGNLRSPG WPDNYDNDKD
3430 3440 3450 3460 3470 3480
CTVTLTAPQN HTISLFFHSL GIENSVECRN DFLEVRNGSN SNSPLLGKYC GTLLPNPVFS
3490 3500 3510 3520 3530 3540
QNNELYLRFK SDSVTSDRGY EIIWTSSPSG CGGTLYGDRG SFTSPGYPGT YPNNTYCEWV
3550 3560 3570 3580 3590 3600
LVAPAGRLVT INFYFISIDD PGDCVQNYLT LYDGPNASSP SSGPYCGGDT SIAPFVASSN
3610 3620
QVFIKFHADY ARRPSAFRLT WDS
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
4 N-termini - 2 C-termini - 6 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O60494-24-unknown | EAGELE... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O60494-36-unknown | SINLQQ... | 36 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O60494-36-unknown | SINLQQ... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26948 | |||
O60494-36-unknown | SINLQQ... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27246 | |||
O60494-36-unknown | SINLQQ... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26534 | |||
O60494-36-unknown | SINLQQ... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26805 | |||
O60494-36-unknown | SINLQQ... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9666 | |||
O60494-36-unknown | SINLQQ... | 36 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27097 | |||
O60494-114-unknown | NSKLVD... | 114 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000415970 | |||
O60494-1479-unknown | STGNEL... | 1479 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000391830 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...QRQKRS | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26948 | |||
...QRQKRS | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27246 | |||
...QRQKRS | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26534 | |||
...QRQKRS | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26805 | |||
...QRQKRS | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9666 | |||
...QRQKRS | 35 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC27097 | |||
...LTWDS | 3623 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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