Q92838: Ectodysplasin-A

General Information

Protein names	- Ectodysplasin-A - Ectodermal dysplasia protein - EDA protein - Ectodysplasin-A, membrane form - Ectodysplasin-A, secreted form
Gene names	EDA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92838

2 N-termini

2 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Ectodysplasin-A - Isoform 3 of Ectodysplasin-A - Isoform 4 of Ectodysplasin-A - Isoform 5 of Ectodysplasin-A - Isoform 6 of Ectodysplasin-A - Isoform 7 of Ectodysplasin-A - Isoform 8 of Ectodysplasin-A

Sequence View

        10         20         30         40         50         60
MGYPEVERRE LLPAAAPRER GSQGCGCGGA PARAGEGNSC LLFLGFFGLS LALHLLTLCC
        70         80         90        100        110        120
YLELRSELRR ERGAESRLGG SGTPGTSGTL SSLGGLDPDS PITSHLGQPS PKQQPLEPGE
       130        140        150        160        170        180
AALHSDSQDG HQMALLNFFF PDEKPYSEEE SRRVRRNKRS KSNEGADGPV KNKKKGKKAG
       190        200        210        220        230        240
PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK
       250        260        270        280        290        300
AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT
       310        320        330        340        350        360
YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI
       370        380        390
AVKMVHADIS INMSKHTTFF GAIRLGEAPA S         10         20         30         40         50         60
MGYPEVERRE LLPAAAPRER GSQGCGCGGA PARAGEGNSC LLFLGFFGLS LALHLLTLCC
        70         80         90        100        110        120
YLELRSELRR ERGAESRLGG SGTPGTSGTL SSLGGLDPDS PITSHLGQPS PKQQPLEPGE
       130        140        150        160        170        180
AALHSDSQDG HQMALLNFFF PDEKPYSEEE SRRVRRNKRS KSNEGADGPV KNKKKGKKAG
       190        200        210        220        230        240
PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK
       250        260        270        280        290        300
AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT
       310        320        330        340        350        360
YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI
       370        380        390
AVKMVHADIS INMSKHTTFF GAIRLGEAPA S         10         20         30         40         50         60
MGYPEVERRE LLPAAAPRER GSQGCGCGGA PARAGEGNSC LLFLGFFGLS LALHLLTLCC
        70         80         90        100        110        120
YLELRSELRR ERGAESRLGG SGTPGTSGTL SSLGGLDPDS PITSHLGQPS PKQQPLEPGE
       130        140        150        160        170        180
AALHSDSQDG HQMALLNFFF PDEKPYSEEE SRRVRRNKRS KSNEGADGPV KNKKKGKKAG
       190        200        210        220        230        240
PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK
       250        260        270        280        290        300
AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT
       310        320        330        340        350        360
YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI
       370        380        390
AVKMVHADIS INMSKHTTFF GAIRLGEAPA S         10         20         30         40         50         60
MGYPEVERRE LLPAAAPRER GSQGCGCGGA PARAGEGNSC LLFLGFFGLS LALHLLTLCC
        70         80         90        100        110        120
YLELRSELRR ERGAESRLGG SGTPGTSGTL SSLGGLDPDS PITSHLGQPS PKQQPLEPGE
       130        140        150        160        170        180
AALHSDSQDG HQMALLNFFF PDEKPYSEEE SRRVRRNKRS KSNEGADGPV KNKKKGKKAG
       190        200        210        220        230        240
PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK
       250        260        270        280        290        300
AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT
       310        320        330        340        350        360
YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI
       370        380        390
AVKMVHADIS INMSKHTTFF GAIRLGEAPA S         10         20         30         40         50         60
MGYPEVERRE LLPAAAPRER GSQGCGCGGA PARAGEGNSC LLFLGFFGLS LALHLLTLCC
        70         80         90        100        110        120
YLELRSELRR ERGAESRLGG SGTPGTSGTL SSLGGLDPDS PITSHLGQPS PKQQPLEPGE
       130        140        150        160        170        180
AALHSDSQDG HQMALLNFFF PDEKPYSEEE SRRVRRNKRS KSNEGADGPV KNKKKGKKAG
       190        200        210        220        230        240
PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK
       250        260        270        280        290        300
AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT
       310        320        330        340        350        360
YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI
       370        380        390
AVKMVHADIS INMSKHTTFF GAIRLGEAPA S         10         20         30         40         50         60
MGYPEVERRE LLPAAAPRER GSQGCGCGGA PARAGEGNSC LLFLGFFGLS LALHLLTLCC
        70         80         90        100        110        120
YLELRSELRR ERGAESRLGG SGTPGTSGTL SSLGGLDPDS PITSHLGQPS PKQQPLEPGE
       130        140        150        160        170        180
AALHSDSQDG HQMALLNFFF PDEKPYSEEE SRRVRRNKRS KSNEGADGPV KNKKKGKKAG
       190        200        210        220        230        240
PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK
       250        260        270        280        290        300
AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT
       310        320        330        340        350        360
YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI
       370        380        390
AVKMVHADIS INMSKHTTFF GAIRLGEAPA S         10         20         30         40         50         60
MGYPEVERRE LLPAAAPRER GSQGCGCGGA PARAGEGNSC LLFLGFFGLS LALHLLTLCC
        70         80         90        100        110        120
YLELRSELRR ERGAESRLGG SGTPGTSGTL SSLGGLDPDS PITSHLGQPS PKQQPLEPGE
       130        140        150        160        170        180
AALHSDSQDG HQMALLNFFF PDEKPYSEEE SRRVRRNKRS KSNEGADGPV KNKKKGKKAG
       190        200        210        220        230        240
PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK
       250        260        270        280        290        300
AGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT
       310        320        330        340        350        360
YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI
       370        380        390
AVKMVHADIS INMSKHTTFF GAIRLGEAPA S

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q92838-1-unknown	MGYPEV...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q92838-1-unknown	MGYPEV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73615
Q92838-1-unknown	MGYPEV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73616
Q92838-1-unknown	MGYPEV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73617
Q92838-1-unknown	MGYPEV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73618
Q92838-1-unknown	MGYPEV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73619
Q92838-1-unknown	MGYPEV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73620
Q92838-1-unknown	MGYPEV...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73621
Q92838-160-unknown	SKSNEG...	160	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q92838-160-unknown	SKSNEG...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26651
Q92838-160-unknown	SKSNEG...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26921
Q92838-160-unknown	SKSNEG...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27219
Q92838-160-unknown	SKSNEG...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9819
Q92838-160-unknown	SKSNEG...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27071
Q92838-160-unknown	SKSNEG...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27366
Q92838-160-unknown	SKSNEG...	160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115974
Q92838-160-unknown	SKSNEG...	160	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115975

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRNKRS	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26651
...RRNKRS	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26921
...RRNKRS	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27219
...RRNKRS	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9819
...RRNKRS	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27071
...RRNKRS	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27366
...RRNKRS	159	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128407
...RRNKRS	159	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128408
...EAPAS	391	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EAPAS	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69239
...EAPAS	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69234

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEC2_HUMAN	159	NKRS.\|.SKSN	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	159	NKRS.\|.SKSN	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	159	NKRS.\|.SKSN	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	159	NKRS.\|.SKSN	inferred from experiment	unknown	MEROPS	Morris NP	Chen Y et al.:Mutations within a furin consen... (S08.071)	11416205,
PCSK5_HUMAN	159	NKRS.\|.SKSN	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	159	NKRS.\|.SKSN	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)