P23560: Brain-derived neurotrophic factor

General Information

Protein names	- Brain-derived neurotrophic factor - BDNF - Abrineurin - BDNF precursor form {ECO:0000305} - ProBDNF {ECO:0000305}
Gene names	BDNF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P23560

4 N-termini

4 C-termini

9 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Brain-derived neurotrophic factor - Isoform 3 of Brain-derived neurotrophic factor - Isoform 4 of Brain-derived neurotrophic factor - Isoform 5 of Brain-derived neurotrophic factor

Sequence View

        10         20         30         40         50         60
MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA
        70         80         90        100        110        120
DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA
       130        140        150        160        170        180
NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY
       190        200        210        220        230        240
FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT

LTIKRGR         10         20         30         40         50         60
MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA
        70         80         90        100        110        120
DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA
       130        140        150        160        170        180
NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY
       190        200        210        220        230        240
FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT

LTIKRGR         10         20         30         40         50         60
MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA
        70         80         90        100        110        120
DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA
       130        140        150        160        170        180
NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY
       190        200        210        220        230        240
FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT

LTIKRGR         10         20         30         40         50         60
MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA
        70         80         90        100        110        120
DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA
       130        140        150        160        170        180
NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY
       190        200        210        220        230        240
FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT

LTIKRGR

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P23560-19-unknown	APMKEA...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P23560-19-unknown	APMKEA...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112062
P23560-19-unknown	APMKEA...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112061
P23560-19-unknown	APMKEA...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112059
P23560-19-unknown	APMKEA...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112060
P23560-58-unknown	SLADTF...	58	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16822
P23560-58-unknown	SLADTF...	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140385
P23560-58-unknown	SLADTF...	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140852
P23560-58-unknown	SLADTF...	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141675
P23560-58-unknown	SLADTF...	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144317
P23560-126-unknown	VRRHSD...	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27567
P23560-126-unknown	VRRHSD...	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144049
P23560-126-unknown	VRRHSD...	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144376
P23560-126-unknown	VRRHSD...	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144953
P23560-126-unknown	VRRHSD...	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146856
P23560-129-unknown	HSDPAR...	129	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P23560-129-unknown	HSDPAR...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26885
P23560-129-unknown	HSDPAR...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9755
P23560-129-unknown	HSDPAR...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27177
P23560-129-unknown	HSDPAR...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27030
P23560-129-unknown	HSDPAR...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27329
P23560-129-unknown	HSDPAR...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16334
P23560-129-unknown	HSDPAR...	129	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26615
P23560-129-unknown	HSDPAR...	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115923
P23560-129-unknown	HSDPAR...	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115922
P23560-129-unknown	HSDPAR...	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115920
P23560-129-unknown	HSDPAR...	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115921

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SRGLTS	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16822
...SRGLTS	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123508
...SRGLTS	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123992
...SRGLTS	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124857
...SRGLTS	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127579
...NMSMRV	125	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27567
...NMSMRV	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127300
...NMSMRV	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127639
...NMSMRV	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128230
...NMSMRV	125	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130182
...MRVRRH	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26885
...MRVRRH	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9755
...MRVRRH	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27177
...MRVRRH	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27030
...MRVRRH	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27329
...MRVRRH	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16334
...MRVRRH	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26615
...MRVRRH	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127408
...MRVRRH	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127737
...MRVRRH	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128335
...MRVRRH	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130312
...IKRGR	247	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IKRGR	247	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63970
...IKRGR	247	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63971
...IKRGR	247	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63973
...IKRGR	247	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63972

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MBTP1_HUMAN	57	GLTS.\|.SLAD	inferred from experiment	unknown	MEROPS		Merops MBTP1_HUMAN -> BDNF_HUMAN @57
PLMN_HUMAN	125	SMRV.\|.VRRH	inferred from experiment	unknown	MEROPS	Ellis V	Gray K et al.:Activation of pro-BDNF by the p... (S01.233)	18291105,
PCSK4_HUMAN	128	VRRH.\|.HSDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	128	VRRH.\|.HSDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK6_HUMAN	128	VRRH.\|.HSDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	128	VRRH.\|.HSDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	128	VRRH.\|.HSDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
KLK4_HUMAN	128	VRRH.\|.HSDP	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
NEC2_HUMAN	128	VRRH.\|.HSDP	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)