TopFIND 4.0

Q14703: Membrane-bound transcription factor site-1 protease

General Information

Protein names
- Membrane-bound transcription factor site-1 protease
- 3.4.21.112
- Endopeptidase S1P
- Subtilisin/kexin-isozyme 1
- SKI-1
Gene names MBTPS1
Organism Homo sapiens
Protease Family S08.063
Protease ID S08.063
Chromosome location
UniProt ID Q14703

4

N-termini

5

C-termini

3

Cleavages

26

Substrates

Sequence

        10         20         30         40         50         60 
MKLVNIWLLL LVVLLCGKKH LGDRLEKKSF EKAPCPGCSH LTLKVEFSST VVEYEYIVAF 
        70         80         90        100        110        120 
NGYFTAKARN SFISSALKSS EVDNWRIIPR NNPSSDYPSD FEVIQIKEKQ KAGLLTLEDH 
       130        140        150        160        170        180 
PNIKRVTPQR KVFRSLKYAE SDPTVPCNET RWSQKWQSSR PLRRASLSLG SGFWHATGRH 
       190        200        210        220        230        240 
SSRRLLRAIP RQVAQTLQAD VLWQMGYTGA NVRVAVFDTG LSEKHPHFKN VKERTNWTNE 
       250        260        270        280        290        300 
RTLDDGLGHG TFVAGVIASM RECQGFAPDA ELHIFRVFTN NQVSYTSWFL DAFNYAILKK 
       310        320        330        340        350        360 
IDVLNLSIGG PDFMDHPFVD KVWELTANNV IMVSAIGNDG PLYGTLNNPA DQMDVIGVGG 
       370        380        390        400        410        420 
IDFEDNIARF SSRGMTTWEL PGGYGRMKPD IVTYGAGVRG SGVKGGCRAL SGTSVASPVV 
       430        440        450        460        470        480 
AGAVTLLVST VQKRELVNPA SMKQALIASA RRLPGVNMFE QGHGKLDLLR AYQILNSYKP 
       490        500        510        520        530        540 
QASLSPSYID LTECPYMWPY CSQPIYYGGM PTVVNVTILN GMGVTGRIVD KPDWQPYLPQ 
       550        560        570        580        590        600 
NGDNIEVAFS YSSVLWPWSG YLAISISVTK KAASWEGIAQ GHVMITVASP AETESKNGAE 
       610        620        630        640        650        660 
QTSTVKLPIK VKIIPTPPRS KRVLWDQYHN LRYPPGYFPR DNLRMKNDPL DWNGDHIHTN 
       670        680        690        700        710        720 
FRDMYQHLRS MGYFVEVLGA PFTCFDASQY GTLLMVDSEE EYFPEEIAKL RRDVDNGLSL 
       730        740        750        760        770        780 
VIFSDWYNTS VMRKVKFYDE NTRQWWMPDT GGANIPALNE LLSVWNMGFS DGLYEGEFTL 
       790        800        810        820        830        840 
ANHDMYYASG CSIAKFPEDG VVITQTFKDQ GLEVLKQETA VVENVPILGL YQIPAEGGGR 
       850        860        870        880        890        900 
IVLYGDSNCL DDSHRQKDCF WLLDALLQYT SYGVTPPSLS HSGNRQRPPS GAGSVTPERM 
       910        920        930        940        950        960 
EGNHLHRYSK VLEAHLGDPK PRPLPACPRL SWAKPQPLNE TAPSNLWKHQ KLLSIDLDKV 
       970        980        990       1000       1010       1020 
VLPNFRSNRP QVRPLSPGES GAWDIPGGIM PGRYNQEVGQ TIPVFAFLGA MVVLAFFVVQ 
      1030       1040       1050    
INKAKSRPKR RKPRVKRPQL MQQVHPPKTP SV

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 3 Cleavages - 26 Substrates

N-termini

C-termini

Cleavages

Substrates