Q12772: Sterol regulatory element-binding protein 2

General Information

Protein names	- Sterol regulatory element-binding protein 2 - SREBP-2 - Class D basic helix-loop-helix protein 2 - bHLHd2 - Sterol regulatory element-binding transcription factor 2 - Processed sterol regulatory element-binding protein 2
Gene names	SREBF2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12772

5 N-termini

6 C-termini

6 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MDDSGELGGL ETMETLTELG DELTLGDIDE MLQFVSNQVG EFPDLFSEQL CSSFPGSGGS
        70         80         90        100        110        120
GSSSGSSGSS SSSSNGRGSS SGAVDPSVQR SFTQVTLPSF SPSAASPQAP TLQVKVSPTS
       130        140        150        160        170        180
VPTTPRATPI LQPRPQPQPQ PQTQLQQQTV MITPTFSTTP QTRIIQQPLI YQNAATSFQV
       190        200        210        220        230        240
LQPQVQSLVT SSQVQPVTIQ QQVQTVQAQR VLTQTANGTL QTLAPATVQT VAAPQVQQVP
       250        260        270        280        290        300
VLVQPQIIKT DSLVLTTLKT DGSPVMAAVQ NPALTALTTP IQTAALQVPT LVGSSGTILT
       310        320        330        340        350        360
TMPVMMGQEK VPIKQVPGGV KQLEPPKEGE RRTTHNIIEK RYRSSINDKI IELKDLVMGT
       370        380        390        400        410        420
DAKMHKSGVL RKAIDYIKYL QQVNHKLRQE NMVLKLANQK NKLLKGIDLG SLVDNEVDLK
       430        440        450        460        470        480
IEDFNQNVLL MSPPASDSGS QAGFSPYSID SEPGSPLLDD AKVKDEPDSP PVALGMVDRS
       490        500        510        520        530        540
RILLCVLTFL CLSFNPLTSL LQWGGAHDSD QHPHSGSGRS VLSFESGSGG WFDWMMPTLL
       550        560        570        580        590        600
LWLVNGVIVL SVFVKLLVHG EPVIRPHSRS SVTFWRHRKQ ADLDLARGDF AAAAGNLQTC
       610        620        630        640        650        660
LAVLGRALPT SRLDLACSLS WNVIRYSLQK LRLVRWLLKK VFQCRRATPA TEAGFEDEAK
       670        680        690        700        710        720
TSARDAALAY HRLHQLHITG KLPAGSACSD VHMALCAVNL AECAEEKIPP STLVEIHLTA
       730        740        750        760        770        780
AMGLKTRCGG KLGFLASYFL SRAQSLCGPE HSAVPDSLRW LCHPLGQKFF MERSWSVKSA
       790        800        810        820        830        840
AKESLYCAQR NPADPIAQVH QAFCKNLLER AIESLVKPQA KKKAGDQEEE SCEFSSALEY
       850        860        870        880        890        900
LKLLHSFVDS VGVMSPPLSR SSVLKSALGP DIICRWWTSA ITVAISWLQG DDAAVRSHFT
       910        920        930        940        950        960
KVERIPKALE VTESPLVKAI FHACRAMHAS LPGKADGQQS SFCHCERASG HLWSSLNVSG
       970        980        990       1000       1010       1020
ATSDPALNHV VQLLTCDLLL SLRTALWQKQ ASASQAVGET YHASGAELAG FQRDLGSLRR
      1030       1040       1050       1060       1070       1080
LAHSFRPAYR KVFLHEATVR LMAGASPTRT HQLLEHSLRR RTTQSTKHGE VDAWPGQRER
      1090       1100       1110       1120       1130       1140
ATAILLACRH LPLSFLSSPG QRAVLLAEAA RTLEKVGDRR SCNDCQQMIV KLGGGTAIAA

S

Isoforms

- Isoform 2 of Sterol regulatory element-binding protein 2

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 6 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q12772-1-unknown	MDDSGE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q12772-1-unknown	MDDSGE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90616
Q12772-469-unknown	SPPVAL...	469	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1280
Q12772-469-unknown	SPPVAL...	469	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2131
Q12772-469-unknown	SPPVAL...	469	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2954
Q12772-469-unknown	SPPVAL...	469	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152984
Q12772-485-unknown	CVLTFL...	485	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16844
Q12772-485-unknown	CVLTFL...	485	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153225
Q12772-491-unknown	CLSFNP...	491	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16846
Q12772-491-unknown	CLSFNP...	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153290
Q12772-523-unknown	SFESGS...	523	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16831
Q12772-523-unknown	SFESGS...	523	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153628

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KDEPDS	468	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1280
...KDEPDS	468	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2131
...KDEPDS	468	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2954
...KDEPDS	468	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136410
...SRILLC	484	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SRILLC	484	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16844
...SRILLC	484	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92906
...VLTFLC	490	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16846
...VLTFLC	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136714
...GRSVLS	522	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16831
...GRSVLS	522	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137051
...QSTKHG	1068	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412287
...AIAAS	1141	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	468	EPDS.\|.SPPV	inferred from experiment	unknown	MEROPS	Brown MS	Wang X et al.:Purification of an interleukin-... (C14.001)	7629113,
CASP3_HUMAN	468	EPDS.\|.SPPV	inferred from experiment	unknown	MEROPS	Brown MS	Wang X et al.:Purification of an interleukin-... (C14.003)	7629113,
CASP7_HUMAN	468	EPDS.\|.SPPV	inferred from experiment	unknown	MEROPS		Merops CASP7_HUMAN -> SRBP2_HUMAN @468
MBTP2_HUMAN	484	ILLC.\|.CVLT	inferred from experiment	unknown	MEROPS		Merops MBTP2_HUMAN -> SRBP2_HUMAN @484
MBTP2_HUMAN	490	TFLC.\|.CLSF	inferred from experiment	unknown	MEROPS		Merops MBTP2_HUMAN -> SRBP2_HUMAN @490
MBTP1_HUMAN	522	SVLS.\|.SFES	inferred from experiment	unknown	MEROPS	Marcinkiewicz M	Seidah NG et al.:Mammalian subtilisin/kexin isoz... (S08.063)	9990022,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)