TopFIND 4.0

O43462: Membrane-bound transcription factor site-2 protease

General Information

Protein names
- Membrane-bound transcription factor site-2 protease
- 3.4.24.85
- Endopeptidase S2P
- Sterol regulatory element-binding proteins intramembrane protease
- SREBPs intramembrane protease
Gene names MBTPS2
Organism Homo sapiens
Protease Family M50.001
Protease ID M50.001
Chromosome location
UniProt ID O43462

1

N-termini

1

C-termini

0

Cleavages

4

Substrates

Sequence

        10         20         30         40         50         60 
MIPVSLVVVV VGGWTVVYLT DLVLKSSVYF KHSYEDWLEN NGLSISPFHI RWQTAVFNRA 
        70         80         90        100        110        120 
FYSWGRRKAR MLYQWFNFGM VFGVIAMFSS FFLLGKTLMQ TLAQMMADSP SSYSSSSSSS 
       130        140        150        160        170        180 
SSSSSSSSSS SSSSSSLHNE QVLQVVVPGI NLPVNQLTYF FTAVLISGVV HEIGHGIAAI 
       190        200        210        220        230        240 
REQVRFNGFG IFLFIIYPGA FVDLFTTHLQ LISPVQQLRI FCAGIWHNFV LALLGILALV 
       250        260        270        280        290        300 
LLPVILLPFY YTGVGVLITE VAEDSPAIGP RGLFVGDLVT HLQDCPVTNV QDWNECLDTI 
       310        320        330        340        350        360 
AYEPQIGYCI SASTLQQLSF PVRAYKRLDG STECCNNHSL TDVCFSYRNN FNKRLHTCLP 
       370        380        390        400        410        420 
ARKAVEATQV CRTNKDCKKS SSSSFCIIPS LETHTRLIKV KHPPQIDMLY VGHPLHLHYT 
       430        440        450        460        470        480 
VSITSFIPRF NFLSIDLPVV VETFVKYLIS LSGALAIVNA VPCFALDGQW ILNSFLDATL 
       490        500        510    
TSVIGDNDVK DLIGFFILLG GSVLLAANVT LGLWMVTAR

Isoforms



Sequence View



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 4 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    O43462-1-unknown MIPVSL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...MVTAR 519 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates