P36956: Sterol regulatory element-binding protein 1

General Information

Protein names	- Sterol regulatory element-binding protein 1 - SREBP-1 - Class D basic helix-loop-helix protein 1 - bHLHd1 - Sterol regulatory element-binding transcription factor 1 - Processed sterol regulatory element-binding protein 1
Gene names	SREBF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P36956

3 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform SREBP-1B of Sterol regulatory element-binding protein 1 - Isoform SREBP-1C of Sterol regulatory element-binding protein 1 - Isoform 4 of Sterol regulatory element-binding protein 1 - Isoform SREBP-1aDelta of Sterol regulatory element-binding protein 1 - Isoform SREBP-1cDelta of Sterol regulatory element-binding protein 1

Sequence View

        10         20         30         40         50         60
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP YAGSGAGGTD
        70         80         90        100        110        120
PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP QPAPTPLKMY PSMPAFSPGP
       130        140        150        160        170        180
GIKEESVPLS ILQTPTPQPL PGALLPQSFP APAPPQFSST PVLGYPSPPG GFSTGSPPGN
       190        200        210        220        230        240
TQQPLPGLPL ASPPGVPPVS LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL
       250        260        270        280        290        300
QPHFIKADSL LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
       310        320        330        340        350        360
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV VGTEAKLNKS
       370        380        390        400        410        420
AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL VSACGSGGNT DVLMEGVKTE
       430        440        450        460        470        480
VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR
       490        500        510        520        530        540
GMLDRSRLAL CTLVFLCLSC NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW
       550        560        570        580        590        600
AQWLLPPVVW LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
       610        620        630        640        650        660
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG GLQQDCALRV
       670        680        690        700        710        720
DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL NLAECAGDAV SVATLAEIYV
       730        740        750        760        770        780
AAALRVKTSL PRALHFLTRF FLSSARQACL AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL
       790        800        810        820        830        840
STPWESLYSL AGNPVDPLAQ VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL
       850        860        870        880        890        900
QLLNSCSDAA GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
       910        920        930        940        950        960
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG YLQDSLATTP
       970        980        990       1000       1010       1020
ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT SSRPQASALE LRGFQRDLSS
      1030       1040       1050       1060       1070       1080
LRRLAQSFRP AMRRVFLHEA TARLMAGASP TRTHQLLDRS LRRRAGPGGK GGAVAELEPR
      1090       1100       1110       1120       1130       1140
PTRREHAEAL LLASCYLPPG FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG

GTTVTSS         10         20         30         40         50         60
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP YAGSGAGGTD
        70         80         90        100        110        120
PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP QPAPTPLKMY PSMPAFSPGP
       130        140        150        160        170        180
GIKEESVPLS ILQTPTPQPL PGALLPQSFP APAPPQFSST PVLGYPSPPG GFSTGSPPGN
       190        200        210        220        230        240
TQQPLPGLPL ASPPGVPPVS LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL
       250        260        270        280        290        300
QPHFIKADSL LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
       310        320        330        340        350        360
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV VGTEAKLNKS
       370        380        390        400        410        420
AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL VSACGSGGNT DVLMEGVKTE
       430        440        450        460        470        480
VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR
       490        500        510        520        530        540
GMLDRSRLAL CTLVFLCLSC NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW
       550        560        570        580        590        600
AQWLLPPVVW LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
       610        620        630        640        650        660
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG GLQQDCALRV
       670        680        690        700        710        720
DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL NLAECAGDAV SVATLAEIYV
       730        740        750        760        770        780
AAALRVKTSL PRALHFLTRF FLSSARQACL AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL
       790        800        810        820        830        840
STPWESLYSL AGNPVDPLAQ VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL
       850        860        870        880        890        900
QLLNSCSDAA GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
       910        920        930        940        950        960
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG YLQDSLATTP
       970        980        990       1000       1010       1020
ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT SSRPQASALE LRGFQRDLSS
      1030       1040       1050       1060       1070       1080
LRRLAQSFRP AMRRVFLHEA TARLMAGASP TRTHQLLDRS LRRRAGPGGK GGAVAELEPR
      1090       1100       1110       1120       1130       1140
PTRREHAEAL LLASCYLPPG FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG

GTTVTSS         10         20         30         40         50         60
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP YAGSGAGGTD
        70         80         90        100        110        120
PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP QPAPTPLKMY PSMPAFSPGP
       130        140        150        160        170        180
GIKEESVPLS ILQTPTPQPL PGALLPQSFP APAPPQFSST PVLGYPSPPG GFSTGSPPGN
       190        200        210        220        230        240
TQQPLPGLPL ASPPGVPPVS LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL
       250        260        270        280        290        300
QPHFIKADSL LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
       310        320        330        340        350        360
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV VGTEAKLNKS
       370        380        390        400        410        420
AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL VSACGSGGNT DVLMEGVKTE
       430        440        450        460        470        480
VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR
       490        500        510        520        530        540
GMLDRSRLAL CTLVFLCLSC NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW
       550        560        570        580        590        600
AQWLLPPVVW LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
       610        620        630        640        650        660
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG GLQQDCALRV
       670        680        690        700        710        720
DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL NLAECAGDAV SVATLAEIYV
       730        740        750        760        770        780
AAALRVKTSL PRALHFLTRF FLSSARQACL AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL
       790        800        810        820        830        840
STPWESLYSL AGNPVDPLAQ VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL
       850        860        870        880        890        900
QLLNSCSDAA GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
       910        920        930        940        950        960
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG YLQDSLATTP
       970        980        990       1000       1010       1020
ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT SSRPQASALE LRGFQRDLSS
      1030       1040       1050       1060       1070       1080
LRRLAQSFRP AMRRVFLHEA TARLMAGASP TRTHQLLDRS LRRRAGPGGK GGAVAELEPR
      1090       1100       1110       1120       1130       1140
PTRREHAEAL LLASCYLPPG FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG

GTTVTSS         10         20         30         40         50         60
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP YAGSGAGGTD
        70         80         90        100        110        120
PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP QPAPTPLKMY PSMPAFSPGP
       130        140        150        160        170        180
GIKEESVPLS ILQTPTPQPL PGALLPQSFP APAPPQFSST PVLGYPSPPG GFSTGSPPGN
       190        200        210        220        230        240
TQQPLPGLPL ASPPGVPPVS LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL
       250        260        270        280        290        300
QPHFIKADSL LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
       310        320        330        340        350        360
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV VGTEAKLNKS
       370        380        390        400        410        420
AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL VSACGSGGNT DVLMEGVKTE
       430        440        450        460        470        480
VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR
       490        500        510        520        530        540
GMLDRSRLAL CTLVFLCLSC NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW
       550        560        570        580        590        600
AQWLLPPVVW LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
       610        620        630        640        650        660
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG GLQQDCALRV
       670        680        690        700        710        720
DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL NLAECAGDAV SVATLAEIYV
       730        740        750        760        770        780
AAALRVKTSL PRALHFLTRF FLSSARQACL AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL
       790        800        810        820        830        840
STPWESLYSL AGNPVDPLAQ VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL
       850        860        870        880        890        900
QLLNSCSDAA GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
       910        920        930        940        950        960
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG YLQDSLATTP
       970        980        990       1000       1010       1020
ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT SSRPQASALE LRGFQRDLSS
      1030       1040       1050       1060       1070       1080
LRRLAQSFRP AMRRVFLHEA TARLMAGASP TRTHQLLDRS LRRRAGPGGK GGAVAELEPR
      1090       1100       1110       1120       1130       1140
PTRREHAEAL LLASCYLPPG FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG

GTTVTSS         10         20         30         40         50         60
MDEPPFSEAA LEQALGEPCD LDAALLTDIE DMLQLINNQD SDFPGLFDPP YAGSGAGGTD
        70         80         90        100        110        120
PASPDTSSPG SLSPPPATLS SSLEAFLSGP QAAPSPLSPP QPAPTPLKMY PSMPAFSPGP
       130        140        150        160        170        180
GIKEESVPLS ILQTPTPQPL PGALLPQSFP APAPPQFSST PVLGYPSPPG GFSTGSPPGN
       190        200        210        220        230        240
TQQPLPGLPL ASPPGVPPVS LHTQVQSVVP QQLLTVTAAP TAAPVTTTVT SQIQQVPVLL
       250        260        270        280        290        300
QPHFIKADSL LLTAMKTDGA TVKAAGLSPL VSGTTVQTGP LPTLVSGGTI LATVPLVVDA
       310        320        330        340        350        360
EKLPINRLAA GSKAPASAQS RGEKRTAHNA IEKRYRSSIN DKIIELKDLV VGTEAKLNKS
       370        380        390        400        410        420
AVLRKAIDYI RFLQHSNQKL KQENLSLRTA VHKSKSLKDL VSACGSGGNT DVLMEGVKTE
       430        440        450        460        470        480
VEDTLTPPPS DAGSPFQSSP LSLGSRGSGS GGSGSDSEPD SPVFEDSKAK PEQRPSLHSR
       490        500        510        520        530        540
GMLDRSRLAL CTLVFLCLSC NPLASLLGAR GLPSPSDTTS VYHSPGRNVL GTESRDGPGW
       550        560        570        580        590        600
AQWLLPPVVW LLNGLLVLVS LVLLFVYGEP VTRPHSGPAV YFWRHRKQAD LDLARGDFAQ
       610        620        630        640        650        660
AAQQLWLALR ALGRPLPTSH LDLACSLLWN LIRHLLQRLW VGRWLAGRAG GLQQDCALRV
       670        680        690        700        710        720
DASASARDAA LVYHKLHQLH TMGKHTGGHL TATNLALSAL NLAECAGDAV SVATLAEIYV
       730        740        750        760        770        780
AAALRVKTSL PRALHFLTRF FLSSARQACL AQSGSVPPAM QWLCHPVGHR FFVDGDWSVL
       790        800        810        820        830        840
STPWESLYSL AGNPVDPLAQ VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL
       850        860        870        880        890        900
QLLNSCSDAA GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL
       910        920        930        940        950        960
VEHLPRVLQE SERPLPRAAL HSFKAARALL GCAKAESGPA SLTICEKASG YLQDSLATTP
       970        980        990       1000       1010       1020
ASSSIDKAVQ LFLCDLLLVV RTSLWRQQQP PAPAPAAQGT SSRPQASALE LRGFQRDLSS
      1030       1040       1050       1060       1070       1080
LRRLAQSFRP AMRRVFLHEA TARLMAGASP TRTHQLLDRS LRRRAGPGGK GGAVAELEPR
      1090       1100       1110       1120       1130       1140
PTRREHAEAL LLASCYLPPG FLSAPGQRVG MLAEAARTLE KLGDRRLLHD CQQMLMRLGG

GTTVTSS

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(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P36956-1-unknown	MDEPPF...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P36956-1-unknown	MDEPPF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90608
P36956-1-unknown	MDEPPF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90610
P36956-1-unknown	MDEPPF...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90611
P36956-461-unknown	SPVFED...	461	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1220
P36956-461-unknown	SPVFED...	461	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152593
P36956-461-unknown	SPVFED...	461	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152931
P36956-461-unknown	SPVFED...	461	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153318
P36956-531-unknown	GTESRD...	531	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16827
P36956-531-unknown	GTESRD...	531	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153504
P36956-531-unknown	GTESRD...	531	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153762
P36956-531-unknown	GTESRD...	531	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154130

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DSEPDS	460	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1220
...DSEPDS	460	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136010
...DSEPDS	460	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136357
...DSEPDS	460	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136742
...SRLALC	490	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SRLALC	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92921
...SRLALC	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92922
...SRLALC	490	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92920
...GRNVLG	530	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16827
...GRNVLG	530	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136926
...GRNVLG	530	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137184
...GRNVLG	530	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137550
...TVTSS	1147	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TVTSS	1147	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86228

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	460	EPDS.\|.SPVF	inferred from experiment	unknown	MEROPS	Brown MS	Wang X et al.:Purification of an interleukin-... (C14.001)	7629113,
MBTP1_HUMAN	530	NVLG.\|.GTES	inferred from experiment	unknown	MEROPS	Seidah NG	Pasquato A et al.:The proprotein convertase SKI-1... (S08.063)	16790437,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)