P21754: Zona pellucida sperm-binding protein 3

General Information

Protein names	- Zona pellucida sperm-binding protein 3 - Sperm receptor - ZP3A/ZP3B - Zona pellucida glycoprotein 3 - Zp-3 - Zona pellucida protein C - Processed zona pellucida sperm-binding protein 3
Gene names	ZP3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P21754

4 N-termini

4 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform ZP3B of Zona pellucida sperm-binding protein 3 - Isoform 3 of Zona pellucida sperm-binding protein 3

Sequence View

        10         20         30         40         50         60
MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF
        70         80         90        100        110        120
GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP
       130        140        150        160        170        180
RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN
       190        200        210        220        230        240
WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL
       250        260        270        280        290        300
VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC
       310        320        330        340        350        360
SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV
       370        380        390        400        410        420
TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV

SASE         10         20         30         40         50         60
MELSYRLFIC LLLWGSTELC YPQPLWLLQG GASHPETSVQ PVLVECQEAT LMVMVSKDLF
        70         80         90        100        110        120
GTGKLIRAAD LTLGPEACEP LVSMDTEDVV RFEVGLHECG NSMQVTDDAL VYSTFLLHDP
       130        140        150        160        170        180
RPVGNLSIVR TNRAEIPIEC RYPRQGNVSS QAILPTWLPF RTTVFSEEKL TFSLRLMEEN
       190        200        210        220        230        240
WNAEKRSPTF HLGDAAHLQA EIHTGSHVPL RLFVDHCVAT PTPDQNASPY HTIVDFHGCL
       250        260        270        280        290        300
VDGLTDASSA FKVPRPGPDT LQFTVDVFHF ANDSRNMIYI TCHLKVTLAE QDPDELNKAC
       310        320        330        340        350        360
SFSKPSNSWF PVEGSADICQ CCNKGDCGTP SHSRRQPHVM SQWSRSASRN RRHVTEEADV
       370        380        390        400        410        420
TVGPLIFLDR RGDHEVEQWA LPSDTSVVLL GVGLAVVVSL TLTAVILVLT RRCRTASHPV

SASE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
P21754-1-unknown	MELSYR...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt95662
P21754-23-Pyrrolidone carboxylic acid	QPLWLL...	23	pyrrolidone carboxylic acid-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P21754-23-Pyrrolidone carboxylic acid	QPLWLL...	23	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113250
P21754-52-unknown	MVMVSK...	52		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt95663
P21754-52-unknown	MVMVSK...	52		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt105685
P21754-353-unknown	HVTEEA...	353		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9745
P21754-353-unknown	HVTEEA...	353		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27166
P21754-353-unknown	HVTEEA...	353		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27019
P21754-353-unknown	HVTEEA...	353		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27318
P21754-353-unknown	HVTEEA...	353		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26605
P21754-353-unknown	HVTEEA...	353		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26874
P21754-353-unknown	HVTEEA...	353		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149912

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SASRNR	350	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SASRNR	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92474
...SASRNR	350	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt92475
...SRNRRH	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9745
...SRNRRH	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27166
...SRNRRH	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27019
...SRNRRH	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27318
...SRNRRH	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26605
...SRNRRH	352	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26874
...SRNRRH	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133304
...SRNRRH	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134401
...VSASE	424	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91281

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	352	NRRH.\|.HVTE	inferred from experiment	unknown	MEROPS	Saling P	Kiefer SM et al.:Proteolytic processing of human... (S08.071)	11804956,
PCSK6_HUMAN	352	NRRH.\|.HVTE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK5_HUMAN	352	NRRH.\|.HVTE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	352	NRRH.\|.HVTE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	352	NRRH.\|.HVTE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	352	NRRH.\|.HVTE	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)