P55786: Puromycin-sensitive aminopeptidase

General Information

Protein names	- Puromycin-sensitive aminopeptidase - PSA - 3.4.11.14 - Cytosol alanyl aminopeptidase - AAP-S
Gene names	NPEPPS
Organism	Homo sapiens
Protease Family	M01.010
Protease ID	M01.010
Chromosome location
UniProt ID	P55786

8 N-termini

7 C-termini

3 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MWLAAAAPSL ARRLLFLGPP PPPLLLLVFS RSSRRRLHSL GLAAMPEKRP FERLPADVSP
        70         80         90        100        110        120
INYSLCLKPD LLDFTFEGKL EAAAQVRQAT NQIVMNCADI DIITASYAPE GDEEIHATGF
       130        140        150        160        170        180
NYQNEDEKVT LSFPSTLQTG TGTLKIDFVG ELNDKMKGFY RSKYTTPSGE VRYAAVTQFE
       190        200        210        220        230        240
ATDARRAFPC WDEPAIKATF DISLVVPKDR VALSNMNVID RKPYPDDENL VEVKFARTPV
       250        260        270        280        290        300
MSTYLVAFVV GEYDFVETRS KDGVCVRVYT PVGKAEQGKF ALEVAAKTLP FYKDYFNVPY
       310        320        330        340        350        360
PLPKIDLIAI ADFAAGAMEN WGLVTYRETA LLIDPKNSCS SSRQWVALVV GHELAHQWFG
       370        380        390        400        410        420
NLVTMEWWTH LWLNEGFASW IEYLCVDHCF PEYDIWTQFV SADYTRAQEL DALDNSHPIE
       430        440        450        460        470        480
VSVGHPSEVD EIFDAISYSK GASVIRMLHD YIGDKDFKKG MNMYLTKFQQ KNAATEDLWE
       490        500        510        520        530        540
SLENASGKPI AAVMNTWTKQ MGFPLIYVEA EQVEDDRLLR LSQKKFCAGG SYVGEDCPQW
       550        560        570        580        590        600
MVPITISTSE DPNQAKLKIL MDKPEMNVVL KNVKPDQWVK LNLGTVGFYR TQYSSAMLES
       610        620        630        640        650        660
LLPGIRDLSL PPVDRLGLQN DLFSLARAGI ISTVEVLKVM EAFVNEPNYT VWSDLSCNLG
       670        680        690        700        710        720
ILSTLLSHTD FYEEIQEFVK DVFSPIGERL GWDPKPGEGH LDALLRGLVL GKLGKAGHKA
       730        740        750        760        770        780
TLEEARRRFK DHVEGKQILS ADLRSPVYLT VLKHGDGTTL DIMLKLHKQA DMQEEKNRIE
       790        800        810        820        830        840
RVLGATLLPD LIQKVLTFAL SEEVRPQDTV SVIGGVAGGS KHGRKAAWKF IKDNWEELYN
       850        860        870        880        890        900
RYQGGFLISR LIKLSVEGFA VDKMAGEVKA FFESHPAPSA ERTIQQCCEN ILLNAAWLKR
       910
DAESIHQYLL QRKASPPTV

Isoforms

- Isoform 2 of Puromycin-sensitive aminopeptidase

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 7 C-termini - 3 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P55786-1-unknown	MWLAAA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P55786-41-unknown	GLAAMP...	41		unknown		Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P55786-45-unknown	MPEKRP...	45	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442461
P55786-318-unknown	MENWGL...	318	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435639
P55786-562-unknown	DKPEMN...	562	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19222
P55786-766-unknown	LHKQAD...	766	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433549
P55786-785-unknown	ATLLPD...	785	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17749
P55786-812-unknown	VIGGVA...	812	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3869

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...RVALSN	214	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000437019
...KNAATE	475	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435639
...KNAATE	475	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000435966
...LKILMD	561	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19222
...ERVLGA	784	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17749
...QDTVSV	811	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3869
...SPPTV	919	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SPPTV	919		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...SPPTV	919		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	561	ILMD.\|.DKPE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	784	VLGA.\|.ATLL	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	811	TVSV.\|.VIGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PDYN_HUMAN	175	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS		Merops PSA_HUMAN -> PDYN_HUMAN @175
COLI_HUMAN	237	KRYG.\|.GGFM	inferred from experiment	unknown	MEROPS		Merops PSA_HUMAN -> COLI_HUMAN @237