P09960: Leukotriene A-4 hydrolase

General Information

Protein names	- Leukotriene A-4 hydrolase - LTA-4 hydrolase - 3.3.2.6 - Leukotriene A(4) hydrolase
Gene names	LTA4H
Organism	Homo sapiens
Protease Family	M01.004
Protease ID	M01.004
Chromosome location
UniProt ID	P09960

12 N-termini

7 C-termini

7 Cleavages

2 Substrates

Sequence

Isoforms

- Isoform 2 of Leukotriene A-4 hydrolase - Isoform 3 of Leukotriene A-4 hydrolase - Isoform 4 of Leukotriene A-4 hydrolase

Sequence View

        10         20         30         40         50         60
MPEIVDTCSL ASPASVCRTK HLHLRCSVDF TRRTLTGTAA LTVQSQEDNL RSLVLDTKDL
        70         80         90        100        110        120
TIEKVVINGQ EVKYALGERQ SYKGSPMEIS LPIALSKNQE IVIEISFETS PKSSALQWLT
       130        140        150        160        170        180
PEQTSGKEHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGETP
       190        200        210        220        230        240
DPEDPSRKIY KFIQKVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES
       250        260        270        280        290        300
MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH
       310        320        330        340        350        360
SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FNALGGWGEL QNSVKTFGET
       370        380        390        400        410        420
HPFTKLVVDL TDIDPDVAYS SVPYEKGFAL LFYLEQLLGG PEIFLGFLKA YVEKFSYKSI
       430        440        450        460        470        480
TTDDWKDFLY SYFKDKVDVL NQVDWNAWLY SPGLPPIKPN YDMTLTNACI ALSQRWITAK
       490        500        510        520        530        540
EDDLNSFNAT DLKDLSSHQL NEFLAQTLQR APLPLGHIKR MQEVYNFNAI NNSEIRFRWL
       550        560        570        580        590        600
RLCIQSKWED AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKASMHPVT
       610
AMLVGKDLKV D         10         20         30         40         50         60
MPEIVDTCSL ASPASVCRTK HLHLRCSVDF TRRTLTGTAA LTVQSQEDNL RSLVLDTKDL
        70         80         90        100        110        120
TIEKVVINGQ EVKYALGERQ SYKGSPMEIS LPIALSKNQE IVIEISFETS PKSSALQWLT
       130        140        150        160        170        180
PEQTSGKEHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGETP
       190        200        210        220        230        240
DPEDPSRKIY KFIQKVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES
       250        260        270        280        290        300
MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH
       310        320        330        340        350        360
SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FNALGGWGEL QNSVKTFGET
       370        380        390        400        410        420
HPFTKLVVDL TDIDPDVAYS SVPYEKGFAL LFYLEQLLGG PEIFLGFLKA YVEKFSYKSI
       430        440        450        460        470        480
TTDDWKDFLY SYFKDKVDVL NQVDWNAWLY SPGLPPIKPN YDMTLTNACI ALSQRWITAK
       490        500        510        520        530        540
EDDLNSFNAT DLKDLSSHQL NEFLAQTLQR APLPLGHIKR MQEVYNFNAI NNSEIRFRWL
       550        560        570        580        590        600
RLCIQSKWED AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKASMHPVT
       610
AMLVGKDLKV D         10         20         30         40         50         60
MPEIVDTCSL ASPASVCRTK HLHLRCSVDF TRRTLTGTAA LTVQSQEDNL RSLVLDTKDL
        70         80         90        100        110        120
TIEKVVINGQ EVKYALGERQ SYKGSPMEIS LPIALSKNQE IVIEISFETS PKSSALQWLT
       130        140        150        160        170        180
PEQTSGKEHP YLFSQCQAIH CRAILPCQDT PSVKLTYTAE VSVPKELVAL MSAIRDGETP
       190        200        210        220        230        240
DPEDPSRKIY KFIQKVPIPC YLIALVVGAL ESRQIGPRTL VWSEKEQVEK SAYEFSETES
       250        260        270        280        290        300
MLKIAEDLGG PYVWGQYDLL VLPPSFPYGG MENPCLTFVT PTLLAGDKSL SNVIAHEISH
       310        320        330        340        350        360
SWTGNLVTNK TWDHFWLNEG HTVYLERHIC GRLFGEKFRH FNALGGWGEL QNSVKTFGET
       370        380        390        400        410        420
HPFTKLVVDL TDIDPDVAYS SVPYEKGFAL LFYLEQLLGG PEIFLGFLKA YVEKFSYKSI
       430        440        450        460        470        480
TTDDWKDFLY SYFKDKVDVL NQVDWNAWLY SPGLPPIKPN YDMTLTNACI ALSQRWITAK
       490        500        510        520        530        540
EDDLNSFNAT DLKDLSSHQL NEFLAQTLQR APLPLGHIKR MQEVYNFNAI NNSEIRFRWL
       550        560        570        580        590        600
RLCIQSKWED AIPLALKMAT EQGRMKFTRP LFKDLAAFDK SHDQAVRTYQ EHKASMHPVT
       610
AMLVGKDLKV D

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Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

12 N-termini - 7 C-termini - 7 Cleavages - 2 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P09960-1-unknown	MPEIVD...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79692
P09960-2-unknown	PEIVDT...	2		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09960-2-unknown	PEIVDT...	2			COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P09960-2-unknown	PEIVDT...	2			COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P09960-2-unknown	PEIVDT...	2		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110552
P09960-2-unmodified	PEIVDT...	2			other		CNRS/ISV	Large_scale_NTA_Human
P09960-34-acetylation	TLTGTA...	34	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09960-34-acetylation	TLTGTA...	34	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181533
P09960-38-unknown	TAALTV...	38		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3554
P09960-38-unknown	TAALTV...	38		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138218
P09960-176-unknown	DGETPD...	176		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181529
P09960-176-unknown	DGETPD...	176		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181530
P09960-176-unknown	DGETPD...	176		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt181531
P09960-176-	DGETPD...	176			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09960-343-unknown	ALGGWG...	343		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3556
P09960-343-unknown	ALGGWG...	343		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150318
P09960-343-unknown	ALGGWG...	343		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150319
P09960-343-unknown	ALGGWG...	343		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150807
P09960-344-unknown	LGGWGE...	344		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3560
P09960-344-unknown	LGGWGE...	344		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150344
P09960-344-unknown	LGGWGE...	344		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150345
P09960-344-unknown	LGGWGE...	344		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150834
P09960-345-unknown	GGWGEL...	345		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3564
P09960-345-unknown	GGWGEL...	345		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150372
P09960-345-unknown	GGWGEL...	345		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150373
P09960-345-unknown	GGWGEL...	345		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150858
P09960-346-unknown	GWGELQ...	346		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3568
P09960-346-unknown	GWGELQ...	346		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150399
P09960-346-unknown	GWGELQ...	346		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150401
P09960-346-unknown	GWGELQ...	346		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150877
P09960-359-unknown	ETHPFT...	359		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7269
P09960-359-unknown	ETHPFT...	359		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5524
P09960-359-unknown	ETHPFT...	359		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150612
P09960-359-unknown	ETHPFT...	359		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150613
P09960-359-unknown	ETHPFT...	359		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151137

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RTLTGT	37	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3554
...RTLTGT	37	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121247
...FRHFNA	342	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3556
...FRHFNA	342	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133713
...FRHFNA	342	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133714
...FRHFNA	342	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134209
...RHFNAL	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3560
...RHFNAL	343	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133741
...RHFNAL	343	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133742
...RHFNAL	343	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134236
...HFNALG	344	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3564
...HFNALG	344	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133769
...HFNALG	344	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133770
...HFNALG	344	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134259
...FNALGG	345	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3568
...FNALGG	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133796
...FNALGG	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133798
...FNALGG	345	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134279
...VKTFGE	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7269
...VKTFGE	358	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5524
...VKTFGE	358	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134010
...VKTFGE	358	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134011
...VKTFGE	358	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134539
...DLKVD	611	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DLKVD	611	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt75312

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	37	LTGT.\|.TAAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	342	HFNA.\|.ALGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	343	FNAL.\|.LGGW	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	344	NALG.\|.GGWG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	345	ALGG.\|.GWGE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	358	TFGE.\|.ETHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	358	TFGE.\|.ETHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PDYN_HUMAN	175	KRYG.\|.GGFL	inferred from experiment	unknown	MEROPS	Fitzpatrick FA	Griffin KJ et al.:Opioid peptides are substrates ... (M01.004)	1410529,
COLI_HUMAN	237	KRYG.\|.GGFM	inferred from experiment	unknown	MEROPS	Fitzpatrick FA	Griffin KJ et al.:Opioid peptides are substrates ... (M01.004)	1410529,