P14138: Endothelin-3

General Information

Protein names	- Endothelin-3 - ET-3 - Preproendothelin-3 - PPET3
Gene names	EDN3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P14138

8 N-termini

7 C-termini

8 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Short of Endothelin-3 - Isoform 3 of Endothelin-3

Sequence View

        10         20         30         40         50         60
MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG
        70         80         90        100        110        120
PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT
       130        140        150        160        170        180
PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS
       190        200        210        220        230
SNSRTAEKTD KEEEGKVEVK DQQSKQALDL HHPKLMPGSG LALAPSTCPR CLFQEGAP         10         20         30         40         50         60
MEPGLWLLFG LTVTSAAGFV PCSQSGDAGR RGVSQAPTAA RSEGDCEETV AGPGEETVAG
        70         80         90        100        110        120
PGEGTVAPTA LQGPSPGSPG QEQAAEGAPE HHRSRRCTCF TYKDKECVYY CHLDIIWINT
       130        140        150        160        170        180
PEQTVPYGLS NYRGSFRGKR SAGPLPGNLQ LSHRPHLRCA CVGRYDKACL HFCTQTLDVS
       190        200        210        220        230
SNSRTAEKTD KEEEGKVEVK DQQSKQALDL HHPKLMPGSG LALAPSTCPR CLFQEGAP

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 7 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P14138-1-unknown	MEPGLW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73636
P14138-1-unknown	MEPGLW...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73637
P14138-17-unknown	AGFVPC...	17	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P14138-17-unknown	AGFVPC...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111847
P14138-17-unknown	AGFVPC...	17	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111848
P14138-100-unknown	FTYKDK...	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26727
P14138-100-unknown	FTYKDK...	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142404
P14138-100-unknown	FTYKDK...	100	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142405
P14138-108-unknown	VYYCHL...	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26730
P14138-108-unknown	VYYCHL...	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142823
P14138-108-unknown	VYYCHL...	108	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt142824
P14138-113-unknown	LDIIWI...	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26733
P14138-113-unknown	LDIIWI...	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143119
P14138-113-unknown	LDIIWI...	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143120
P14138-115-unknown	IIWINT...	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26736
P14138-115-unknown	IIWINT...	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143238
P14138-115-unknown	IIWINT...	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143239
P14138-118-unknown	INTPEQ...	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4721
P14138-118-unknown	INTPEQ...	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8568
P14138-118-unknown	INTPEQ...	118	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15788
P14138-118-unknown	INTPEQ...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143373
P14138-118-unknown	INTPEQ...	118	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143375
P14138-128-unknown	GLSNYR...	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8415
P14138-128-unknown	GLSNYR...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143826
P14138-128-unknown	GLSNYR...	128	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143827

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RRCTCF	99	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26727
...RRCTCF	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125597
...RRCTCF	99	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125598
...KDKECV	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26730
...KDKECV	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126029
...KDKECV	107	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126030
...VYYCHL	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26733
...VYYCHL	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126340
...VYYCHL	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126341
...YCHLDI	114	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26736
...YCHLDI	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126466
...YCHLDI	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126467
...LDIIWI	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4721
...LDIIWI	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8568
...LDIIWI	117	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15788
...LDIIWI	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126605
...LDIIWI	117	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126607
...QTVPYG	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8415
...QTVPYG	127	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127069
...QTVPYG	127	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127070
...QEGAP	238	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69254

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEP_HUMAN	99	CTCF.\|.FTYK	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
NEP_HUMAN	107	KECV.\|.VYYC	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
NEP_HUMAN	112	YCHL.\|.LDII	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
NEP_HUMAN	114	HLDI.\|.IIWI	inferred from experiment	unknown	MEROPS	Hersh LB	Vijayaraghavan J et al.:The hydrolysis of endothelins b... (M13.001)	2201681,
CATE_HUMAN	117	IIWI.\|.INTP	inferred from experiment	unknown	MEROPS	Cook ND	Robinson PS et al.:Kinetic parameters for the gene... (A01.010)	1599425,
ECE1_HUMAN	117	IIWI.\|.INTP	inferred from experiment	unknown	MEROPS		Merops ECE1_HUMAN -> EDN3_HUMAN @117
KELL_HUMAN	117	IIWI.\|.INTP	inferred from experiment	unknown	MEROPS	Redman C	Lee S et al.:Proteolytic processing of big e... (M13.090)	10438732,
CMA1_HUMAN	127	VPYG.\|.GLSN	inferred from experiment	unknown	MEROPS	Kido H	Nakano A et al.:Selective conversion of big end... (S01.140)	9257865,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)