P23276: Kell blood group glycoprotein

General Information

Protein names	- Kell blood group glycoprotein - 3.4.24.- - CD238
Gene names	KEL
Organism	Homo sapiens
Protease Family	M13.090
Protease ID	M13.090
Chromosome location
UniProt ID	P23276

3 N-termini

3 C-termini

0 Cleavages

15 Substrates

Sequence

        10         20         30         40         50         60
MEGGDQSEEE PRERSQAGGM GTLWSQESTP EERLPVEGSR PWAVARRVLT AILILGLLLC
        70         80         90        100        110        120
FSVLLFYNFQ NCGPRPCETS VCLDLRDHYL ASGNTSVAPC TDFFSFACGR AKETNNSFQE
       130        140        150        160        170        180
LATKNKNRLR RILEVQNSWH PGSGEEKAFQ FYNSCMDTLA IEAAGTGPLR QVIEELGGWR
       190        200        210        220        230        240
ISGKWTSLNF NRTLRLLMSQ YGHFPFFRAY LGPHPASPHT PVIQIDQPEF DVPLKQDQEQ
       250        260        270        280        290        300
KIYAQIFREY LTYLNQLGTL LGGDPSKVQE HSSLSISITS RLFQFLRPLE QRRAQGKLFQ
       310        320        330        340        350        360
MVTIDQLKEM APAIDWLSCL QATFTPMSLS PSQSLVVHDV EYLKNMSQLV EEMLLKQRDF
       370        380        390        400        410        420
LQSHMILGLV VTLSPALDSQ FQEARRKLSQ KLRELTEQPP MPARPRWMKC VEETGTFFEP
       430        440        450        460        470        480
TLAALFVREA FGPSTRSAAM KLFTAIRDAL ITRLRNLPWM NEETQNMAQD KVAQLQVEMG
       490        500        510        520        530        540
ASEWALKPEL ARQEYNDIQL GSSFLQSVLS CVRSLRARIV QSFLQPHPQH RWKVSPWDVN
       550        560        570        580        590        600
AYYSVSDHVV VFPAGLLQPP FFHPGYPRAV NFGAAGSIMA HELLHIFYQL LLPGGCLACD
       610        620        630        640        650        660
NHALQEAHLC LKRHYAAFPL PSRTSFNDSL TFLENAADVG GLAIALQAYS KRLLRHHGET
       670        680        690        700        710        720
VLPSLDLSPQ QIFFRSYAQV MCRKPSPQDS HDTHSPPHLR VHGPLSSTPA FARYFRCARG
       730
ALLNPSSRCQ LW

Isoforms

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 15 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P23276-1-acetylation	MEGGDQ...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P23276-1-unknown	MEGGDQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P23276-20-unknown	MGTLWS...	20		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000420011
P23276-20-unknown	MGTLWS...	20		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000455756

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QVIEEL	175	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000418886
...QVIEEL	175	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000454843
...HTPVIQ	223	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000420011
...HTPVIQ	223	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455756
...RCQLW	732	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TKN1-Isoform4_HUMAN	63	PQQF.\|.FFGL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15791
TKN1-Isoform3_HUMAN	63	PQQF.\|.FFGL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15791
TKN1-Isoform2_HUMAN	63	PQQF.\|.FFGL	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15791
TKN1_HUMAN	63	PQQF.\|.FFGL	inferred from experiment	unknown	MEROPS	Ouimet T	Claperon A et al.:The Kell protein of the common ... (M13.090)	15769748,
TKN1-Isoform2_HUMAN	64	QQFF.\|.FGLM	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15795
TKN1_HUMAN	64	QQFF.\|.FGLM	inferred from experiment	unknown	MEROPS	Ouimet T	Claperon A et al.:The Kell protein of the common ... (M13.090)	15769748,
TKN1-Isoform2_HUMAN	66	FFGL.\|.LMGK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15797
TKN1_HUMAN	66	FFGL.\|.LMGK	inferred from experiment	unknown	MEROPS	Ouimet T	Claperon A et al.:The Kell protein of the common ... (M13.090)	15769748,
EDN2_HUMAN	69	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Redman C	Lee S et al.:Proteolytic processing of big e... (M13.090)	10438732,
EDN1_HUMAN	73	IIWV.\|.VNTP	inferred from experiment	unknown	MEROPS	Redman C	Lee S et al.:Proteolytic processing of big e... (M13.090)	10438732,
TKN1-Isoform3_HUMAN	90	FVGL.\|.LMGK	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15799
TKN1_HUMAN	105	FVGL.\|.LMGK	inferred from experiment	unknown	MEROPS	Ouimet T	Claperon A et al.:The Kell protein of the common ... (M13.090)	15769748,
EDN3-Isoform3_HUMAN	117	IIWI.\|.INTP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15788
EDN3-Isoform2_HUMAN	117	IIWI.\|.INTP	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15788
EDN3_HUMAN	117	IIWI.\|.INTP	inferred from experiment	unknown	MEROPS	Redman C	Lee S et al.:Proteolytic processing of big e... (M13.090)	10438732,